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ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription

Hana Paula Masuda, Luiz Mors Cabral, Lieven De Veylder UGent, Milos Tanurdzic, Janice de Almeida Engler UGent, Danny Geelen UGent, Dirk Inzé UGent, Robert A Martienssen, Paulo CG Ferreira and Adriana S Hemerly UGent (2008) EMBO JOURNAL. 27(20). p.2746-2756
abstract
In multicellular organisms, organogenesis requires a tight control of the balance between cell division and cell differentiation. Distinct signalling pathways that connect both cellular processes with developmental cues might have evolved to suit different developmental plans. Here, we identified and characterized a novel protein that interacts with pre-replication complex (pre-RC) subunits, designated Armadillo BTB Arabidopsis protein 1 (ABAP1). Overexpression of ABAP1 in plants limited mitotic DNA replication and decreased cell proliferation in leaves, whereas ABAP1 downregulation increased cell division rates. Activity of ABAP1 in transcription was supported by its association with the transcription factor AtTCP24. The ABAP1-AtTCP24 complex bound specifically to the promoters of AtCDT1a and AtCDT1b in vitro and in vivo. Moreover, expression levels of AtCDT1a and AtCDT1b were reduced in ABAP1-overexpressing plants and they were increased in plants with reduced levels of ABAP1. We propose that ABAP1 participates in a negative feedback loop regulating mitotic DNA replication during leaf development, either by repressing transcription of pre-RC genes and possibly by regulating pre-RC utilization through direct association with pre-RC components.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SEED DEVELOPMENT, REPEAT PROTEINS, CELL-CYCLE, GENE-EXPRESSION, ARABIDOPSIS-THALIANA, ORIGIN RECOGNITION COMPLEX, TCP, pre-RC, plant development, DNA replication, gene transcription, BINDING, PROLIFERATION, FAMILY, TCP DOMAIN
journal title
EMBO JOURNAL
Embo J.
volume
27
issue
20
pages
2746 - 2756
Web of Science type
Article
Web of Science id
000260501100011
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
8.295 (2008)
JCR rank
26/276 (2008)
JCR quartile
1 (2008)
ISSN
0261-4189
DOI
10.1038/emboj.2008.191
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
445497
handle
http://hdl.handle.net/1854/LU-445497
date created
2008-12-24 02:19:00
date last changed
2016-12-19 15:43:33
@article{445497,
  abstract     = {In multicellular organisms, organogenesis requires a tight control of the balance between cell division and cell differentiation. Distinct signalling pathways that connect both cellular processes with developmental cues might have evolved to suit different developmental plans. Here, we identified and characterized a novel protein that interacts with pre-replication complex (pre-RC) subunits, designated Armadillo BTB Arabidopsis protein 1 (ABAP1). Overexpression of ABAP1 in plants limited mitotic DNA replication and decreased cell proliferation in leaves, whereas ABAP1 downregulation increased cell division rates. Activity of ABAP1 in transcription was supported by its association with the transcription factor AtTCP24. The ABAP1-AtTCP24 complex bound specifically to the promoters of AtCDT1a and AtCDT1b in vitro and in vivo. Moreover, expression levels of AtCDT1a and AtCDT1b were reduced in ABAP1-overexpressing plants and they were increased in plants with reduced levels of ABAP1. We propose that ABAP1 participates in a negative feedback loop regulating mitotic DNA replication during leaf development, either by repressing transcription of pre-RC genes and possibly by regulating pre-RC utilization through direct association with pre-RC components.},
  author       = {Masuda, Hana Paula and Cabral, Luiz Mors and De Veylder, Lieven and Tanurdzic, Milos and de Almeida Engler, Janice and Geelen, Danny and Inz{\'e}, Dirk and Martienssen, Robert A and Ferreira, Paulo CG and Hemerly, Adriana S},
  issn         = {0261-4189},
  journal      = {EMBO JOURNAL},
  keyword      = {SEED DEVELOPMENT,REPEAT PROTEINS,CELL-CYCLE,GENE-EXPRESSION,ARABIDOPSIS-THALIANA,ORIGIN RECOGNITION COMPLEX,TCP,pre-RC,plant development,DNA replication,gene transcription,BINDING,PROLIFERATION,FAMILY,TCP DOMAIN},
  language     = {eng},
  number       = {20},
  pages        = {2746--2756},
  title        = {ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription},
  url          = {http://dx.doi.org/10.1038/emboj.2008.191},
  volume       = {27},
  year         = {2008},
}

Chicago
Masuda, Hana Paula, Luiz Mors Cabral, Lieven De Veylder, Milos Tanurdzic, Janice de Almeida Engler, Danny Geelen, Dirk Inzé, Robert A Martienssen, Paulo CG Ferreira, and Adriana S Hemerly. 2008. “ABAP1 Is a Novel Plant Armadillo BTB Protein Involved in DNA Replication and Transcription.” Embo Journal 27 (20): 2746–2756.
APA
Masuda, H. P., Cabral, L. M., De Veylder, L., Tanurdzic, M., de Almeida Engler, J., Geelen, D., Inzé, D., et al. (2008). ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. EMBO JOURNAL, 27(20), 2746–2756.
Vancouver
1.
Masuda HP, Cabral LM, De Veylder L, Tanurdzic M, de Almeida Engler J, Geelen D, et al. ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. EMBO JOURNAL. 2008;27(20):2746–56.
MLA
Masuda, Hana Paula, Luiz Mors Cabral, Lieven De Veylder, et al. “ABAP1 Is a Novel Plant Armadillo BTB Protein Involved in DNA Replication and Transcription.” EMBO JOURNAL 27.20 (2008): 2746–2756. Print.