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Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel

(2008) EQUINE VETERINARY JOURNAL. 40(4). p.326-331
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Organization
Abstract
Reasons for performing study: Increased plasma (5-HT) concentrations are reported in horses predisposed to develop laminitis and after i.v. infusion of endotoxins. In the equine jejunum contractile 5-HT1A-like receptors show tachyphylaxia upon prolonged activation with 5-HT. Therefore, increased systemic 5-HT release in colic horses could play a possible role in the pathophysiology of ileus. Objective: To investigate possible increased systemic release of 5-HT in colic horses with compromised bowel and to identify the source of 5-HT overload. Methods: Concentrations of 5-HT were determined in plasma and peritoneal fluid (PF) of healthy horses (n = 10), strangulating small intestinal colic horses (n = 18), nonsurgical colic horses (n = 10) and cryptorchid stallions (n = 6). It was attempted to identify the source of 5-HT overload by comparing the blood and PF 5-HT concentrations within horses and by assessing the in vivo platelet activation through determination of the beta-thromboglobulin (beta-TG)/platelet factor 4 (PF4) ratio. Results: All horses in the strangulating small intestinal colic group had plasma (P = 0.006) and PF (P = 0.01) 5-HT concentrations above those found in the control group. Plasma beta-TG/PF4 ratio in these horses exceeded 2 in all cases, indicating in vivo platelet activation. Concentrations of 5-HT in PF of colic horses with compromised bowel were significantly lower than the corresponding plasma concentrations (P = 0.005). Potential relevance: In horses with compromised bowel, significant amounts of 5-HT can be released into the systemic circulation, through massive release of platelet-stored 5-HT. 5-HT is a very potent proinflammatory, vasoconstrictive and immunomodulatory agent. In view of the rapid and prolonged tachyphylaxia, shown for the jejunal 5-HT1A-like receptors, this increased systemic 5-HT release could play a role in the pathophysiology of ileus in horses.
Keywords
beta-thromboglobulin, platelet factor 4 (PF-4), endotoxaemia, ACUTE APPENDICITIS, PLASMA-CONCENTRATIONS, IN-VITRO, 5-HYDROXYTRYPTAMINE, LAMINITIS, RECEPTOR, ENDOTOXEMIA, CONTRACTILITY, disseminated intravascular coagulation (DIC), horse, AGONIST, AMINES

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Citation

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MLA
Delesalle, Catherine, Gerlinde Van de Walle, C Nolten, et al. “Determination of the Source of Increased Serotonin (5-HT) Concentrations in Blood and Peritoneal Fluid of Colic Horses with Compromised Bowel.” EQUINE VETERINARY JOURNAL 40.4 (2008): 326–331. Print.
APA
Delesalle, C., Van de Walle, G., Nolten, C., Ver Donck, L., Van Hemelrijck, A., Drinkenburg, W., De Bosschere, H., et al. (2008). Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel. EQUINE VETERINARY JOURNAL, 40(4), 326–331.
Chicago author-date
Delesalle, Catherine, Gerlinde Van de Walle, C Nolten, L Ver Donck, A Van Hemelrijck, W Drinkenburg, H De Bosschere, et al. 2008. “Determination of the Source of Increased Serotonin (5-HT) Concentrations in Blood and Peritoneal Fluid of Colic Horses with Compromised Bowel.” Equine Veterinary Journal 40 (4): 326–331.
Chicago author-date (all authors)
Delesalle, Catherine, Gerlinde Van de Walle, C Nolten, L Ver Donck, A Van Hemelrijck, W Drinkenburg, H De Bosschere, P Claes, Piet Deprez, Laurence Lefère, Sara Torfs, and Romain Lefebvre. 2008. “Determination of the Source of Increased Serotonin (5-HT) Concentrations in Blood and Peritoneal Fluid of Colic Horses with Compromised Bowel.” Equine Veterinary Journal 40 (4): 326–331.
Vancouver
1.
Delesalle C, Van de Walle G, Nolten C, Ver Donck L, Van Hemelrijck A, Drinkenburg W, et al. Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel. EQUINE VETERINARY JOURNAL. 2008;40(4):326–31.
IEEE
[1]
C. Delesalle et al., “Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel,” EQUINE VETERINARY JOURNAL, vol. 40, no. 4, pp. 326–331, 2008.
@article{444869,
  abstract     = {Reasons for performing study: Increased plasma (5-HT) concentrations are reported in horses predisposed to develop laminitis and after i.v. infusion of endotoxins. In the equine jejunum contractile 5-HT1A-like receptors show tachyphylaxia upon prolonged activation with 5-HT. Therefore, increased systemic 5-HT release in colic horses could play a possible role in the pathophysiology of ileus.
Objective: To investigate possible increased systemic release of 5-HT in colic horses with compromised bowel and to identify the source of 5-HT overload.
Methods: Concentrations of 5-HT were determined in plasma and peritoneal fluid (PF) of healthy horses (n = 10), strangulating small intestinal colic horses (n = 18), nonsurgical colic horses (n = 10) and cryptorchid stallions (n = 6). It was attempted to identify the source of 5-HT overload by comparing the blood and PF 5-HT concentrations within horses and by assessing the in vivo platelet activation through determination of the beta-thromboglobulin (beta-TG)/platelet factor 4 (PF4) ratio.
Results: All horses in the strangulating small intestinal colic group had plasma (P = 0.006) and PF (P = 0.01) 5-HT concentrations above those found in the control group. Plasma beta-TG/PF4 ratio in these horses exceeded 2 in all cases, indicating in vivo platelet activation. Concentrations of 5-HT in PF of colic horses with compromised bowel were significantly lower than the corresponding plasma concentrations (P = 0.005).
Potential relevance: In horses with compromised bowel, significant amounts of 5-HT can be released into the systemic circulation, through massive release of platelet-stored 5-HT. 5-HT is a very potent proinflammatory, vasoconstrictive and immunomodulatory agent. In view of the rapid and prolonged tachyphylaxia, shown for the jejunal 5-HT1A-like receptors, this increased systemic 5-HT release could play a role in the pathophysiology of ileus in horses.},
  author       = {Delesalle, Catherine and Van de Walle, Gerlinde and Nolten, C and Ver Donck, L and Van Hemelrijck, A and Drinkenburg, W and De Bosschere, H and Claes, P and Deprez, Piet and Lefère, Laurence and Torfs, Sara and Lefebvre, Romain},
  issn         = {0425-1644},
  journal      = {EQUINE VETERINARY JOURNAL},
  keywords     = {beta-thromboglobulin,platelet factor 4 (PF-4),endotoxaemia,ACUTE APPENDICITIS,PLASMA-CONCENTRATIONS,IN-VITRO,5-HYDROXYTRYPTAMINE,LAMINITIS,RECEPTOR,ENDOTOXEMIA,CONTRACTILITY,disseminated intravascular coagulation (DIC),horse,AGONIST,AMINES},
  language     = {eng},
  number       = {4},
  pages        = {326--331},
  title        = {Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel},
  url          = {http://dx.doi.org/10.2746/042516408X293583},
  volume       = {40},
  year         = {2008},
}

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