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Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC)

Isabelle François UGent, Alberto Dos Santos Pereira UGent, Frederic Lynen UGent and Patrick Sandra UGent (2008) JOURNAL OF SEPARATION SCIENCE. 31(19). p.3473-3478
abstract
The design of a new interface to hyphen high efficiency supercritical fluid chromatography (SFC) and fast RPLC in a comprehensive configuration is described. SFC x RPLC is a viable alternative to normal phase (NP) LC x RPLC and is characterized by high orthogonality. Compared to NPLC x RPLC an additional advantage is the expansion of supercritical carbon dioxide (CO2) when exposed to atmospheric pressure leading to fractions consisting of solvents that are miscible with the second dimension RPLC mobile phase. The interface consists of a two-position/ten-port switching valve equipped with two packed octadecyl silica (C-18) loops for effective trapping and focusing of the analytes after elution from the SFC dimension. The addition of a water make-up flow to the SFC effluent prior to entering the loops is of fundamental importance to efficiently focus the solutes on the C-18 material and to reduce interferences of expanded CO2 gas on the second dimension separation. The features of the system are illustrated with the analysis of a lemon oil sample.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MULTIDIMENSIONAL SEPARATION, EXTRACTION, QUANTITATIVE-ANALYSIS, GAS-CHROMATOGRAPHY, MASS-SPECTROMETRIC DETECTION, Orthogonality, Lemon oil, Interface, Comprehensive SFC x RPLC, High efficiency SFC, COLUMN, ORTHOGONALITY, MATRICES, TRIACYLGLYCEROLS, EFFICIENCY
journal title
JOURNAL OF SEPARATION SCIENCE
J. Sep. Sci.
volume
31
issue
19
pages
3473-3478 pages
Web of Science type
Article
Web of Science id
000260692900022
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
2.746 (2008)
JCR rank
17/70 (2008)
JCR quartile
1 (2008)
ISSN
1615-9306
DOI
10.1002/jssc.200800267
language
English
UGent publication?
yes
classification
A1
id
444525
handle
http://hdl.handle.net/1854/LU-444525
date created
2008-12-06 15:02:00
date last changed
2010-02-16 21:56:44
@article{444525,
  abstract     = {The design of a new interface to hyphen high efficiency supercritical fluid chromatography (SFC) and fast RPLC in a comprehensive configuration is described. SFC x RPLC is a viable alternative to normal phase (NP) LC x RPLC and is characterized by high orthogonality. Compared to NPLC x RPLC an additional advantage is the expansion of supercritical carbon dioxide (CO2) when exposed to atmospheric pressure leading to fractions consisting of solvents that are miscible with the second dimension RPLC mobile phase. The interface consists of a two-position/ten-port switching valve equipped with two packed octadecyl silica (C-18) loops for effective trapping and focusing of the analytes after elution from the SFC dimension. The addition of a water make-up flow to the SFC effluent prior to entering the loops is of fundamental importance to efficiently focus the solutes on the C-18 material and to reduce interferences of expanded CO2 gas on the second dimension separation. The features of the system are illustrated with the analysis of a lemon oil sample.},
  author       = {Fran\c{c}ois, Isabelle and Dos Santos Pereira, Alberto and Lynen, Frederic and Sandra, Patrick},
  issn         = {1615-9306},
  journal      = {JOURNAL OF SEPARATION SCIENCE},
  keyword      = {MULTIDIMENSIONAL SEPARATION,EXTRACTION,QUANTITATIVE-ANALYSIS,GAS-CHROMATOGRAPHY,MASS-SPECTROMETRIC DETECTION,Orthogonality,Lemon oil,Interface,Comprehensive SFC x RPLC,High efficiency SFC,COLUMN,ORTHOGONALITY,MATRICES,TRIACYLGLYCEROLS,EFFICIENCY},
  language     = {eng},
  number       = {19},
  pages        = {3473--3478},
  title        = {Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC)},
  url          = {http://dx.doi.org/10.1002/jssc.200800267},
  volume       = {31},
  year         = {2008},
}

Chicago
François, Isabelle, Alberto Dos Santos Pereira, Frederic Lynen, and Patrick Sandra. 2008. “Construction of a New Interface for Comprehensive Supercritical Fluid Chromatography x Reversed Phase Liquid Chromatography (SFC x RPLC).” Journal of Separation Science 31 (19): 3473–3478.
APA
François, I., Dos Santos Pereira, A., Lynen, F., & Sandra, P. (2008). Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC). JOURNAL OF SEPARATION SCIENCE, 31(19), 3473–3478.
Vancouver
1.
François I, Dos Santos Pereira A, Lynen F, Sandra P. Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC). JOURNAL OF SEPARATION SCIENCE. 2008;31(19):3473–8.
MLA
François, Isabelle, Alberto Dos Santos Pereira, Frederic Lynen, et al. “Construction of a New Interface for Comprehensive Supercritical Fluid Chromatography x Reversed Phase Liquid Chromatography (SFC x RPLC).” JOURNAL OF SEPARATION SCIENCE 31.19 (2008): 3473–3478. Print.