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Modeling the evolution of molecular systems from a mechanistic perspective

(2014) TRENDS IN PLANT SCIENCE. 19(5). p.292-303
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Abstract
Systems biology-inspired genotype-phenotype mapping models are increasingly being used to study the evolutionary properties of molecular biological systems, in particular the general emergent properties of evolving systems, such as modularity, robustness, and evolvability. However, the level of abstraction at which many of these models operate might not be sufficient to capture all relevant intricacies of biological evolution in sufficient detail. Here, we argue that in particular gene and genome duplications, both evolutionary mechanisms of potentially major importance for the evolution of molecular systems and of special relevance to plant evolution, are not adequately accounted for in most GPM modeling frameworks, and that more fine-grained mechanistic models may significantly advance understanding of how gen(om)e duplication impacts molecular systems evolution.
Keywords
FITNESS LANDSCAPES, PLANT-CELL CYCLE, GENOME DUPLICATIONS, TRADE-OFFS, WHOLE-GENOME, genome duplication, gene duplication, emergent properties, genotype-phenotype mapping, evolutionary systems biology, GENE REGULATORY NETWORKS, HOLEY ADAPTIVE LANDSCAPES, MADS-BOX GENES, TRANSCRIPTIONAL REGULATION, EXTRADIMENSIONAL BYPASS

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Citation

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Chicago
Gutiérrez Betancur, Jayson Arley, and Steven Maere. 2014. “Modeling the Evolution of Molecular Systems from a Mechanistic Perspective.” Trends in Plant Science 19 (5): 292–303.
APA
Gutiérrez Betancur, J. A., & Maere, S. (2014). Modeling the evolution of molecular systems from a mechanistic perspective. TRENDS IN PLANT SCIENCE, 19(5), 292–303.
Vancouver
1.
Gutiérrez Betancur JA, Maere S. Modeling the evolution of molecular systems from a mechanistic perspective. TRENDS IN PLANT SCIENCE. 2014;19(5):292–303.
MLA
Gutiérrez Betancur, Jayson Arley, and Steven Maere. “Modeling the Evolution of Molecular Systems from a Mechanistic Perspective.” TRENDS IN PLANT SCIENCE 19.5 (2014): 292–303. Print.
@article{4443596,
  abstract     = {Systems biology-inspired genotype-phenotype mapping models are increasingly being used to study the evolutionary properties of molecular biological systems, in particular the general emergent properties of evolving systems, such as modularity, robustness, and evolvability. However, the level of abstraction at which many of these models operate might not be sufficient to capture all relevant intricacies of biological evolution in sufficient detail. Here, we argue that in particular gene and genome duplications, both evolutionary mechanisms of potentially major importance for the evolution of molecular systems and of special relevance to plant evolution, are not adequately accounted for in most GPM modeling frameworks, and that more fine-grained mechanistic models may significantly advance understanding of how gen(om)e duplication impacts molecular systems evolution.},
  author       = {Guti{\'e}rrez Betancur, Jayson Arley and Maere, Steven},
  issn         = {1360-1385},
  journal      = {TRENDS IN PLANT SCIENCE},
  keyword      = {FITNESS LANDSCAPES,PLANT-CELL CYCLE,GENOME DUPLICATIONS,TRADE-OFFS,WHOLE-GENOME,genome duplication,gene duplication,emergent properties,genotype-phenotype mapping,evolutionary systems biology,GENE REGULATORY NETWORKS,HOLEY ADAPTIVE LANDSCAPES,MADS-BOX GENES,TRANSCRIPTIONAL REGULATION,EXTRADIMENSIONAL BYPASS},
  language     = {eng},
  number       = {5},
  pages        = {292--303},
  title        = {Modeling the evolution of molecular systems from a mechanistic perspective},
  url          = {http://dx.doi.org/10.1016/j.tplants.2014.03.004},
  volume       = {19},
  year         = {2014},
}

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