Advanced search
1 file | 702.88 KB

Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions

(2015) BRAIN STRUCTURE & FUNCTION. 220(1). p.273-290
Author
Organization
Project
The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n = 33) and older (n = 33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and occipital). A set of bimanual tasks was used to assess various aspects of bimanual motor functioning: the Purdue Pegboard test, simultaneous and alternating finger tapping, a choice reaction time test and a complex visuomotor tracking task. The older adults showed age-related deficits on all measures of bimanual motor performance. Correlation analyses within the older group showed that white matter fractional anisotropy of the CC occipital region was associated with bimanual fine manipulation skills (Purdue Pegboard test), whereas better performance on the other bimanual tasks was related to higher fractional anisotropy in the more anterior premotor, primary motor and primary sensory CC subregions. Such associations were less prominent in the younger group. Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging.
Keywords
Corpus callosum, Fractional anisotropy, DTI, Aging, Bimanual coordination, WHITE-MATTER INTEGRITY, CHOICE-REACTION TIME, TRANSCRANIAL MAGNETIC STIMULATION, AGE-RELATED DIFFERENCES, PURDUE PEGBOARD TEST, MULTIPLE-SCLEROSIS, IN-VIVO, HUMAN BRAIN, LIFE-SPAN, COGNITIVE PERFORMANCE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 702.88 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Serbruyns, L, J Gooijers, Karen Caeyenberghs, RL Meesen, K Cuypers, HM Sisti, A Leemans, and Stephan P Swinnen. 2015. “Bimanual Motor Deficits in Older Adults Predicted by Diffusion Tensor Imaging Metrics of Corpus Callosum Subregions.” Brain Structure & Function 220 (1): 273–290.
APA
Serbruyns, L., Gooijers, J., Caeyenberghs, K., Meesen, R., Cuypers, K., Sisti, H., Leemans, A., et al. (2015). Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions. BRAIN STRUCTURE & FUNCTION, 220(1), 273–290.
Vancouver
1.
Serbruyns L, Gooijers J, Caeyenberghs K, Meesen R, Cuypers K, Sisti H, et al. Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions. BRAIN STRUCTURE & FUNCTION. 2015;220(1):273–90.
MLA
Serbruyns, L, J Gooijers, Karen Caeyenberghs, et al. “Bimanual Motor Deficits in Older Adults Predicted by Diffusion Tensor Imaging Metrics of Corpus Callosum Subregions.” BRAIN STRUCTURE & FUNCTION 220.1 (2015): 273–290. Print.
@article{4431380,
  abstract     = {Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n = 33) and older (n = 33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and occipital). A set of bimanual tasks was used to assess various aspects of bimanual motor functioning: the Purdue Pegboard test, simultaneous and alternating finger tapping, a choice reaction time test and a complex visuomotor tracking task. The older adults showed age-related deficits on all measures of bimanual motor performance. Correlation analyses within the older group showed that white matter fractional anisotropy of the CC occipital region was associated with bimanual fine manipulation skills (Purdue Pegboard test), whereas better performance on the other bimanual tasks was related to higher fractional anisotropy in the more anterior premotor, primary motor and primary sensory CC subregions. Such associations were less prominent in the younger group. Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging.},
  author       = {Serbruyns, L and Gooijers, J and Caeyenberghs, Karen and Meesen, RL and Cuypers, K and Sisti, HM and Leemans, A and Swinnen, Stephan P},
  issn         = {1863-2653},
  journal      = {BRAIN STRUCTURE & FUNCTION},
  keywords     = {Corpus callosum,Fractional anisotropy,DTI,Aging,Bimanual coordination,WHITE-MATTER INTEGRITY,CHOICE-REACTION TIME,TRANSCRANIAL MAGNETIC STIMULATION,AGE-RELATED DIFFERENCES,PURDUE PEGBOARD TEST,MULTIPLE-SCLEROSIS,IN-VIVO,HUMAN BRAIN,LIFE-SPAN,COGNITIVE PERFORMANCE},
  language     = {eng},
  number       = {1},
  pages        = {273--290},
  title        = {Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions},
  url          = {http://dx.doi.org/10.1007/s00429-013-0654-z},
  volume       = {220},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: