Advanced search
1 file | 609.27 KB Add to list

Failure of a dietary model to affect markers of inflammation in domestic cats

Adronie Verbrugghe (UGent) , Geert Janssens (UGent) , Hannelore Van de Velde (UGent) , Eric Cox (UGent) , Stefaan De Smet (UGent) , Bruno Vlaeminck (UGent) and Myriam Hesta (UGent)
Author
Organization
Abstract
Background: Oxidative stress and inflammation can be altered by dietary factors in various species. However, little data are available in true carnivorous species such as domestic cats. As numerous anti-inflammatory and anti-oxidative additives become available and might be of use in cats with chronic low-grade inflammatory diseases, the current study aimed to develop a model of diet-induced inflammation by use of two opposite diets. It was hypothesized that a high fat diet enhanced in n-6 PUFA and with lower concentrations of antioxidants would evoke inflammation and oxidative stress in domestic cats. Results: Sixteen healthy adult cats were allocated to two groups. One group received a moderate fat diet, containing pork lard and salmon oil (AA:(EPA + DHA) ratio 0.19) (MFn-3), while the other group was fed a high fat diet, containing pork lard and chicken fat (AA:(EPA + DHA) ratio 2.06) (HFn-6) for 12 weeks. Prior to and 2, 4, 6, 8, 10 and 12 weeks after starting the testing period, blood samples were collected. Erythrocytic fatty acid profile showed clear alterations in accordance to the dietary fatty acid profile. Serum thiobarbituric acid reactive substances was higher when fed MFn-3 compared to the HFn-6, suggesting augmented oxidative stress. This was associated with a reduced serum vitamin E status, as serum a-tocopherol concentrations were lower with MFn-3, even with higher dietary levels of vitamin E. Serum cytokine and serum amyloid A concentrations were not influenced by diet. Conclusion: These results point towards a resistance of cats to develop dietary fat-induced inflammation, but also suggest a high susceptibility to oxidative stress when fed a fish oil-supplemented diet even with moderate fat level and additional vitamin E.
Keywords
Lipid peroxidation, Dietary fat, Polyunsaturated fatty acids, Feline, Peroxidisability index, Vitamin E status, N-3 FATTY-ACIDS, VITAMIN-E, FISH-OIL, LIPID-PEROXIDATION, OXIDATIVE STRESS, ARACHIDONIC-ACID, IMMUNE FUNCTION, BODY CONDITION, AGED DOGS, PLASMA

Downloads

  • 782 - VetRes 2014 104.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 609.27 KB

Citation

Please use this url to cite or link to this publication:

MLA
Verbrugghe, Adronie, Geert Janssens, Hannelore Van de Velde, et al. “Failure of a Dietary Model to Affect Markers of Inflammation in Domestic Cats.” BMC VETERINARY RESEARCH 10 (2014): n. pag. Print.
APA
Verbrugghe, A., Janssens, G., Van de Velde, H., Cox, E., De Smet, S., Vlaeminck, B., & Hesta, M. (2014). Failure of a dietary model to affect markers of inflammation in domestic cats. BMC VETERINARY RESEARCH, 10.
Chicago author-date
Verbrugghe, Adronie, Geert Janssens, Hannelore Van de Velde, Eric Cox, Stefaan De Smet, Bruno Vlaeminck, and Myriam Hesta. 2014. “Failure of a Dietary Model to Affect Markers of Inflammation in Domestic Cats.” Bmc Veterinary Research 10.
Chicago author-date (all authors)
Verbrugghe, Adronie, Geert Janssens, Hannelore Van de Velde, Eric Cox, Stefaan De Smet, Bruno Vlaeminck, and Myriam Hesta. 2014. “Failure of a Dietary Model to Affect Markers of Inflammation in Domestic Cats.” Bmc Veterinary Research 10.
Vancouver
1.
Verbrugghe A, Janssens G, Van de Velde H, Cox E, De Smet S, Vlaeminck B, et al. Failure of a dietary model to affect markers of inflammation in domestic cats. BMC VETERINARY RESEARCH. 2014;10.
IEEE
[1]
A. Verbrugghe et al., “Failure of a dietary model to affect markers of inflammation in domestic cats,” BMC VETERINARY RESEARCH, vol. 10, 2014.
@article{4430235,
  abstract     = {Background: Oxidative stress and inflammation can be altered by dietary factors in various species. However, little data are available in true carnivorous species such as domestic cats. As numerous anti-inflammatory and anti-oxidative additives become available and might be of use in cats with chronic low-grade inflammatory diseases, the current study aimed to develop a model of diet-induced inflammation by use of two opposite diets. It was hypothesized that a high fat diet enhanced in n-6 PUFA and with lower concentrations of antioxidants would evoke inflammation and oxidative stress in domestic cats.
Results: Sixteen healthy adult cats were allocated to two groups. One group received a moderate fat diet, containing pork lard and salmon oil (AA:(EPA + DHA) ratio 0.19) (MFn-3), while the other group was fed a high fat diet, containing pork lard and chicken fat (AA:(EPA + DHA) ratio 2.06) (HFn-6) for 12 weeks. Prior to and 2, 4, 6, 8, 10 and 12 weeks after starting the testing period, blood samples were collected. Erythrocytic fatty acid profile showed clear alterations in accordance to the dietary fatty acid profile. Serum thiobarbituric acid reactive substances was higher when fed MFn-3 compared to the HFn-6, suggesting augmented oxidative stress. This was associated with a reduced serum vitamin E status, as serum a-tocopherol concentrations were lower with MFn-3, even with higher dietary levels of vitamin E. Serum cytokine and serum amyloid A concentrations were not influenced by diet.
Conclusion: These results point towards a resistance of cats to develop dietary fat-induced inflammation, but also suggest a high susceptibility to oxidative stress when fed a fish oil-supplemented diet even with moderate fat level and additional vitamin E.},
  articleno    = {104},
  author       = {Verbrugghe, Adronie and Janssens, Geert and Van de Velde, Hannelore and Cox, Eric and De Smet, Stefaan and Vlaeminck, Bruno and Hesta, Myriam},
  issn         = {1746-6148},
  journal      = {BMC VETERINARY RESEARCH},
  keywords     = {Lipid peroxidation,Dietary fat,Polyunsaturated fatty acids,Feline,Peroxidisability index,Vitamin E status,N-3 FATTY-ACIDS,VITAMIN-E,FISH-OIL,LIPID-PEROXIDATION,OXIDATIVE STRESS,ARACHIDONIC-ACID,IMMUNE FUNCTION,BODY CONDITION,AGED DOGS,PLASMA},
  language     = {eng},
  pages        = {9},
  title        = {Failure of a dietary model to affect markers of inflammation in domestic cats},
  url          = {http://dx.doi.org/10.1186/1746-6148-10-104},
  volume       = {10},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: