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Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity

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Keywords
1-Azabicyclo[2.2.1]heptanes, Aziridines, Ring transformation, Antimalarial agents, INHIBITORS, KEY STEP, IMINO COMPOUNDS, CHIRAL AZIRIDINES, MUSCARINIC RECEPTOR, SUBSTITUTED PIPERIDINES, MALARIA PARASITE, PLASMODIUM-FALCIPARUM, PROTEASE PLASMEPSIN-II, LITHIUM ALUMINUM-HYDRIDE, Plasmepsin II, Ligand docking

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Chicago
D’hooghe, Matthias, Karel Vervisch, Karl W Törnroos, Tom Verhaeghe, Tom Desmet, Carmen Lategan, Peter J Smith, Kelly Chibale, and Norbert De Kimpe. 2013. “Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced Reductive Cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) Aziridines and Evaluation of Their Antimalarial Activity.” Bioorganic & Medicinal Chemistry Letters 23 (5): 1507–1510.
APA
D’hooghe, M., Vervisch, K., Törnroos, K. W., Verhaeghe, T., Desmet, T., Lategan, C., Smith, P. J., et al. (2013). Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23(5), 1507–1510.
Vancouver
1.
D’hooghe M, Vervisch K, Törnroos KW, Verhaeghe T, Desmet T, Lategan C, et al. Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2013;23(5):1507–10.
MLA
D’hooghe, Matthias, Karel Vervisch, Karl W Törnroos, et al. “Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced Reductive Cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) Aziridines and Evaluation of Their Antimalarial Activity.” BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.5 (2013): 1507–1510. Print.
@article{4428021,
  author       = {D'hooghe, Matthias and Vervisch, Karel and T{\"o}rnroos, Karl W and Verhaeghe, Tom and Desmet, Tom and Lategan, Carmen and Smith, Peter J and Chibale, Kelly and De Kimpe, Norbert},
  issn         = {0960-894X},
  journal      = {BIOORGANIC \& MEDICINAL CHEMISTRY LETTERS},
  language     = {eng},
  number       = {5},
  pages        = {1507--1510},
  title        = {Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity},
  url          = {http://dx.doi.org/10.1016/j.bmcl.2012.12.029},
  volume       = {23},
  year         = {2013},
}

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