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Glycated nail proteins : a new approach for detecting diabetes in developing countries

Antoine Sadiki Kishabongo, Philippe Katchunga, Elisabeth Van Aken UGent, Marijn Speeckaert UGent, Sabrina Lagniau, DASHTY HUSEIN, Youri Taes and Joris Delanghe UGent (2014) TROPICAL MEDICINE & INTERNATIONAL HEALTH. 19(1). p.58-64
abstract
Objective: To assess glycation of nail proteins as a tool in the diagnosis of diabetes. Methods: Glycation of nail proteins was assessed using a modified photometric nitroblue tetrazolium-based assay, which provides information about average glucose values of the last 6-9months. Analysis is possible on 10mg of nail clippings with a within-run coefficient of variation (CV) of 11%. The analyte is extremely stable. The reference range for glycated nail protein (0.55-3.60mol/g nail) increases upon ageing. Results: In diabetics (n=112), values for glycated nail protein are significantly higher (median: 4.07mol/g nail, IQR: 2.37-6.89mol/g nail, P<0.0001) than in non-diabetics (n=116). ROC analysis shows an AUC of 0.848 (specificity 93.1%; sensitivity 68.9%). Conclusion: This affordable method is a simple alternative for diagnosing diabetes in remote areas as the pre-analytical phase (including all processes from the time a laboratory request is made by a physician until the sample is ready for testing) is extremely robust.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GLYCOSYLATION, HAIR, HEMOGLOBIN, INDEX, HBA1C, BLOOD, HBA(1C), GLUCOSE, FRUCTOSAMINE, SUB-SAHARAN AFRICA, nails, keratin, hair, glycation, fructosamine
journal title
TROPICAL MEDICINE & INTERNATIONAL HEALTH
Trop. Med. Int. Health
volume
19
issue
1
pages
58 - 64
Web of Science type
Article
Web of Science id
000328349000006
JCR category
TROPICAL MEDICINE
JCR impact factor
2.329 (2014)
JCR rank
4/20 (2014)
JCR quartile
1 (2014)
ISSN
1360-2276
DOI
10.1111/tmi.12218
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4422418
handle
http://hdl.handle.net/1854/LU-4422418
date created
2014-06-18 10:15:08
date last changed
2017-10-17 13:43:06
@article{4422418,
  abstract     = {Objective: To assess glycation of nail proteins as a tool in the diagnosis of diabetes.
Methods: Glycation of nail proteins was assessed using a modified photometric nitroblue tetrazolium-based assay, which provides information about average glucose values of the last 6-9months. Analysis is possible on 10mg of nail clippings with a within-run coefficient of variation (CV) of 11\%. The analyte is extremely stable. The reference range for glycated nail protein (0.55-3.60mol/g nail) increases upon ageing.
Results: In diabetics (n=112), values for glycated nail protein are significantly higher (median: 4.07mol/g nail, IQR: 2.37-6.89mol/g nail, P{\textlangle}0.0001) than in non-diabetics (n=116). ROC analysis shows an AUC of 0.848 (specificity 93.1\%; sensitivity 68.9\%).
Conclusion: This affordable method is a simple alternative for diagnosing diabetes in remote areas as the pre-analytical phase (including all processes from the time a laboratory request is made by a physician until the sample is ready for testing) is extremely robust.},
  author       = {Sadiki Kishabongo, Antoine and Katchunga, Philippe and Van Aken, Elisabeth and Speeckaert, Marijn and Lagniau, Sabrina and HUSEIN, DASHTY and Taes, Youri and Delanghe, Joris},
  issn         = {1360-2276},
  journal      = {TROPICAL MEDICINE \& INTERNATIONAL HEALTH},
  keyword      = {GLYCOSYLATION,HAIR,HEMOGLOBIN,INDEX,HBA1C,BLOOD,HBA(1C),GLUCOSE,FRUCTOSAMINE,SUB-SAHARAN AFRICA,nails,keratin,hair,glycation,fructosamine},
  language     = {eng},
  number       = {1},
  pages        = {58--64},
  title        = {Glycated nail proteins : a new approach for detecting diabetes in developing countries},
  url          = {http://dx.doi.org/10.1111/tmi.12218},
  volume       = {19},
  year         = {2014},
}

Chicago
Sadiki Kishabongo, Antoine, Philippe Katchunga, Elisabeth Van Aken, Marijn Speeckaert, Sabrina Lagniau, DASHTY HUSEIN, Youri Taes, and Joris Delanghe. 2014. “Glycated Nail Proteins : a New Approach for Detecting Diabetes in Developing Countries.” Tropical Medicine & International Health 19 (1): 58–64.
APA
Sadiki Kishabongo, A., Katchunga, P., Van Aken, E., Speeckaert, M., Lagniau, S., HUSEIN, D., Taes, Y., et al. (2014). Glycated nail proteins : a new approach for detecting diabetes in developing countries. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 19(1), 58–64.
Vancouver
1.
Sadiki Kishabongo A, Katchunga P, Van Aken E, Speeckaert M, Lagniau S, HUSEIN D, et al. Glycated nail proteins : a new approach for detecting diabetes in developing countries. TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2014;19(1):58–64.
MLA
Sadiki Kishabongo, Antoine, Philippe Katchunga, Elisabeth Van Aken, et al. “Glycated Nail Proteins : a New Approach for Detecting Diabetes in Developing Countries.” TROPICAL MEDICINE & INTERNATIONAL HEALTH 19.1 (2014): 58–64. Print.