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C-ANCA/proteinase 3-positive colitis in children : a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation?

Stephanie Van Biervliet (UGent) , Carolien Bonroy (UGent) , Saskia Vande Velde (UGent) , Ruth De Bruyne (UGent) , Myriam Van Winckel (UGent) , Harald Peeters (UGent) , Joris Delanghe (UGent) , Veronique Stove (UGent) and Martine De Vos (UGent)
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Abstract
Aim: Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context. Methods: Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype. Results: The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P<0.05). None had vasculitis features at diagnosis nor during follow-up. Conclusions: This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.
Keywords
AUTOANTIBODIES, ANCA, ACTIVITY INDEX, WEGENERS-GRANULOMATOSIS, ULCERATIVE-COLITIS, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, vasculitis, inflammatory bowel disease, ANCA, APPRAISAL, GUIDELINES, PROTEINASE-3, SPECIFICITIES

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Chicago
Van Biervliet, Stephanie, Carolien Bonroy, Saskia Vande Velde, Ruth De Bruyne, Myriam Van Winckel, Harald Peeters, Joris Delanghe, Veronique Stove, and Martine De Vos. 2013. “C-ANCA/proteinase 3-positive Colitis in Children : a Distinctive Form of Inflammatory Bowel Disease or Vasculitis with Colitis as Initial Presentation?” Journal of Pediatric Gastroenterology and Nutrition 57 (4): 489–492.
APA
Van Biervliet, Stephanie, Bonroy, C., Vande Velde, S., De Bruyne, R., Van Winckel, M., Peeters, H., Delanghe, J., et al. (2013). C-ANCA/proteinase 3-positive colitis in children : a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation? JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 57(4), 489–492.
Vancouver
1.
Van Biervliet S, Bonroy C, Vande Velde S, De Bruyne R, Van Winckel M, Peeters H, et al. C-ANCA/proteinase 3-positive colitis in children : a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation? JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 2013;57(4):489–92.
MLA
Van Biervliet, Stephanie, Carolien Bonroy, Saskia Vande Velde, et al. “C-ANCA/proteinase 3-positive Colitis in Children : a Distinctive Form of Inflammatory Bowel Disease or Vasculitis with Colitis as Initial Presentation?” JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 57.4 (2013): 489–492. Print.
@article{4422359,
  abstract     = {Aim: Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context.
Methods: Sera from 30 consecutive pediatric patients with IBD were evaluated for ANCA-indirect immunofluorescence and its specific antibodies to investigate whether PR3-ANCA positivity (PR3-ANCA+) identifies a distinct IBD subtype.
Results: The 5 PR3-ANCA+ patients (17%) showed significantly more concomitant biliary disease and severe anal blood loss (P<0.05). None had vasculitis features at diagnosis nor during follow-up.
Conclusions: This pilot study demonstrates significant clinical differences between the PR3-ANCA-positive and -negative IBD subset.},
  author       = {Van Biervliet, Stephanie and Bonroy, Carolien and Vande Velde, Saskia and De Bruyne, Ruth and Van Winckel, Myriam and Peeters, Harald and Delanghe, Joris and Stove, Veronique and De Vos, Martine},
  issn         = {0277-2116},
  journal      = {JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION},
  keywords     = {AUTOANTIBODIES,ANCA,ACTIVITY INDEX,WEGENERS-GRANULOMATOSIS,ULCERATIVE-COLITIS,ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES,vasculitis,inflammatory bowel disease,ANCA,APPRAISAL,GUIDELINES,PROTEINASE-3,SPECIFICITIES},
  language     = {eng},
  number       = {4},
  pages        = {489--492},
  title        = {C-ANCA/proteinase 3-positive colitis in children : a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation?},
  url          = {http://dx.doi.org/10.1097/MPG.0b013e31829d4e9e},
  volume       = {57},
  year         = {2013},
}

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