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Right hemisphere dysfunction and emotional processing in ALS: an fMRI study

(2010) JOURNAL OF NEUROLOGY. 257(12). p.1970-1978
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Abstract
Emotional processing may be abnormal in amyotrophic lateral sclerosis (ALS). Our aim was to explore functional anatomical correlates in the processing of aversive information in ALS patients. We examined the performance of nine non-demented ALS patients and 10 healthy controls on two functional MRI (fMRI) tasks, consisting of an emotional attribution task and a memory recognition task of unpleasant versus neutral stimuli. During the emotional decision task, subjects were asked to select one of three unpleasant or neutral words. During the memory task, subjects were asked to recognize words presented during the previous task. Controls showed, as expected, greater activation in the right middle frontal gyrus during selection of unpleasant than neutral words, and a greater activation mainly in right-sided cerebral areas during the emotional recognition task. Conversely, patients showed a general increase in activation of the left hemisphere, and reduced activation in right hemisphere in both emotional tasks. Such findings may suggest extra-motor neurodegeneration involving key circuits of emotions, mostly negative, commonly involved in FTD.
Keywords
fMRI, ALS, BRAIN, WORDS, ACTIVATION, AMYOTROPHIC-LATERAL-SCLEROSIS, RECOGNITION MEMORY, Lateralization, Negative words, Emotional processing, TASKS

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MLA
Palmieri, A, M Naccarato, S Abrahams, et al. “Right Hemisphere Dysfunction and Emotional Processing in ALS: An fMRI Study.” JOURNAL OF NEUROLOGY 257.12 (2010): 1970–1978. Print.
APA
Palmieri, A, Naccarato, M., Abrahams, S., Bonato, M., D’Ascenzo, C., Balestreri, S., Cima, V., et al. (2010). Right hemisphere dysfunction and emotional processing in ALS: an fMRI study. JOURNAL OF NEUROLOGY, 257(12), 1970–1978.
Chicago author-date
Palmieri, A, M Naccarato, S Abrahams, Mario Bonato, C D’Ascenzo, S Balestreri, V Cima, et al. 2010. “Right Hemisphere Dysfunction and Emotional Processing in ALS: An fMRI Study.” Journal of Neurology 257 (12): 1970–1978.
Chicago author-date (all authors)
Palmieri, A, M Naccarato, S Abrahams, Mario Bonato, C D’Ascenzo, S Balestreri, V Cima, G Querin, R Dal Borgo, L Barachino, C Volpato, C Semenza, E Pegoraro, C Angelini, and G Sorarù. 2010. “Right Hemisphere Dysfunction and Emotional Processing in ALS: An fMRI Study.” Journal of Neurology 257 (12): 1970–1978.
Vancouver
1.
Palmieri A, Naccarato M, Abrahams S, Bonato M, D’Ascenzo C, Balestreri S, et al. Right hemisphere dysfunction and emotional processing in ALS: an fMRI study. JOURNAL OF NEUROLOGY. 2010;257(12):1970–8.
IEEE
[1]
A. Palmieri et al., “Right hemisphere dysfunction and emotional processing in ALS: an fMRI study,” JOURNAL OF NEUROLOGY, vol. 257, no. 12, pp. 1970–1978, 2010.
@article{4417692,
  abstract     = {Emotional processing may be abnormal in amyotrophic lateral sclerosis (ALS). Our aim was to explore functional anatomical correlates in the processing of aversive information in ALS patients. We examined the performance of nine non-demented ALS patients and 10 healthy controls on two functional MRI (fMRI) tasks, consisting of an emotional attribution task and a memory recognition task of unpleasant versus neutral stimuli. During the emotional decision task, subjects were asked to select one of three unpleasant or neutral words. During the memory task, subjects were asked to recognize words presented during the previous task. Controls showed, as expected, greater activation in the right middle frontal gyrus during selection of unpleasant than neutral words, and a greater activation mainly in right-sided cerebral areas during the emotional recognition task. Conversely, patients showed a general increase in activation of the left hemisphere, and reduced activation in right hemisphere in both emotional tasks. Such findings may suggest extra-motor neurodegeneration involving key circuits of emotions, mostly negative, commonly involved in FTD.},
  author       = {Palmieri, A and Naccarato, M and Abrahams, S and Bonato, Mario and D'Ascenzo, C and Balestreri, S and Cima, V and Querin, G and Dal Borgo, R and Barachino, L and Volpato, C and Semenza, C and Pegoraro, E and Angelini, C and Sorarù, G},
  issn         = {0340-5354},
  journal      = {JOURNAL OF NEUROLOGY},
  keywords     = {fMRI,ALS,BRAIN,WORDS,ACTIVATION,AMYOTROPHIC-LATERAL-SCLEROSIS,RECOGNITION MEMORY,Lateralization,Negative words,Emotional processing,TASKS},
  language     = {eng},
  number       = {12},
  pages        = {1970--1978},
  title        = {Right hemisphere dysfunction and emotional processing in ALS: an fMRI study},
  url          = {http://dx.doi.org/10.1007/s00415-010-5640-2},
  volume       = {257},
  year         = {2010},
}

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