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Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms

Gilles Brackman, Katrien Forier UGent, AAA Al Quntar, Evelien De Canck UGent, Claes E Enk, Morris Srebnik, Kevin Braeckmans UGent and Tom Coenye UGent (2014) JOURNAL OF APPLIED MICROBIOLOGY. 116(3). p.492-501
abstract
AIMS: The aim of the present study was to determine the effect of two thiazolidinedione derivatives on Propionibacterium acnes biofilm formation in vitro and to assess their effect on the susceptibility of P. acnes biofilms towards antimicrobials. METHODS AND RESULTS: The compounds were shown to have a moderate to strong antibiofilm activity when used in subinhibitory concentrations. These compounds do not affect P. acnes attachment but lead to increased dispersal of biofilm cells. This dispersal results in an increased killing of the P. acnes biofilm cells by conventional antimicrobials. CONCLUSION: The antibiofilm effect and the effect on biofilm susceptibility of the thiazolidinedione-derived quorum sensing inhibitors were clearly demonstrated. SIGNIFICANCE AND IMPACT OF THE STUDY: Propionibacterium acnes infections are difficult to treat due to the presence of biofilms at the infection site and the associated resistance towards conventional antimicrobials. Our results indicate that these thiazolidinedione derivatives can be promising leads used for the treatment of P. acnes infections and as anti-acne drugs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
IN-VITRO, QUORUM SENSING INHIBITORS, BACTERIA, INFECTIONS, RESISTANCE, SONICATION, VIVO, SKIN
journal title
JOURNAL OF APPLIED MICROBIOLOGY
J. Appl. Microbiol.
volume
116
issue
3
pages
492 - 501
Web of Science type
Article
Web of Science id
000331334500002
JCR category
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
JCR impact factor
2.479 (2014)
JCR rank
60/163 (2014)
JCR quartile
2 (2014)
ISSN
1364-5072
DOI
10.1111/jam.12378
project
NB-Photonics
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4415124
handle
http://hdl.handle.net/1854/LU-4415124
date created
2014-06-13 11:53:06
date last changed
2016-12-19 15:43:04
@article{4415124,
  abstract     = {AIMS: The aim of the present study was to determine the effect of two thiazolidinedione derivatives on Propionibacterium acnes biofilm formation in vitro and to assess their effect on the susceptibility of P. acnes biofilms towards antimicrobials.
METHODS AND RESULTS: The compounds were shown to have a moderate to strong antibiofilm activity when used in subinhibitory concentrations. These compounds do not affect P. acnes attachment but lead to increased dispersal of biofilm cells. This dispersal results in an increased killing of the P. acnes biofilm cells by conventional antimicrobials.
CONCLUSION: The antibiofilm effect and the effect on biofilm susceptibility of the thiazolidinedione-derived quorum sensing inhibitors were clearly demonstrated.
SIGNIFICANCE AND IMPACT OF THE STUDY: Propionibacterium acnes infections are difficult to treat due to the presence of biofilms at the infection site and the associated resistance towards conventional antimicrobials. Our results indicate that these thiazolidinedione derivatives can be promising leads used for the treatment of P. acnes infections and as anti-acne drugs.},
  author       = {Brackman, Gilles and Forier, Katrien and Al Quntar, AAA and De Canck, Evelien and Enk, Claes E and Srebnik, Morris and Braeckmans, Kevin and Coenye, Tom},
  issn         = {1364-5072},
  journal      = {JOURNAL OF APPLIED MICROBIOLOGY},
  keyword      = {IN-VITRO,QUORUM SENSING INHIBITORS,BACTERIA,INFECTIONS,RESISTANCE,SONICATION,VIVO,SKIN},
  language     = {eng},
  number       = {3},
  pages        = {492--501},
  title        = {Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms},
  url          = {http://dx.doi.org/10.1111/jam.12378},
  volume       = {116},
  year         = {2014},
}

Chicago
Brackman, Gilles, Katrien Forier, AAA Al Quntar, Evelien De Canck, Claes E Enk, Morris Srebnik, Kevin Braeckmans, and Tom Coenye. 2014. “Thiazolidinedione Derivatives as Novel Agents Against Propionibacterium Acnes Biofilms.” Journal of Applied Microbiology 116 (3): 492–501.
APA
Brackman, G., Forier, K., Al Quntar, A., De Canck, E., Enk, C. E., Srebnik, M., Braeckmans, K., et al. (2014). Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms. JOURNAL OF APPLIED MICROBIOLOGY, 116(3), 492–501.
Vancouver
1.
Brackman G, Forier K, Al Quntar A, De Canck E, Enk CE, Srebnik M, et al. Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms. JOURNAL OF APPLIED MICROBIOLOGY. 2014;116(3):492–501.
MLA
Brackman, Gilles, Katrien Forier, AAA Al Quntar, et al. “Thiazolidinedione Derivatives as Novel Agents Against Propionibacterium Acnes Biofilms.” JOURNAL OF APPLIED MICROBIOLOGY 116.3 (2014): 492–501. Print.