Advanced search
1 file | 2.02 MB Add to list

Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture

(2014) PLOS ONE. 9(5).
Author
Organization
Project
Abstract
We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher–Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation.
Keywords
HEART, MYOCARDIUM, TISSUE MODEL, FIBER ROTATION, EXCITABLE MEDIUM, Filaments, Filament drift, Scroll waves, Wave propagation, Muscle tissue, Heart, Fibers, Endocardium, Epicardium, Mathematical physiology, Left ventricle, REENTRY, FIBRILLATION, ACTIVATION, MECHANISMS, VORTICES

Downloads

  • journal.pone.0093617.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 2.02 MB

Citation

Please use this url to cite or link to this publication:

MLA
Pravdin, Sergei et al. “Electrical Wave Propagation in an Anisotropic Model of the Left Ventricle Based on Analytical Description of Cardiac Architecture.” PLOS ONE 9.5 (2014): n. pag. Print.
APA
Pravdin, Sergei, Dierckx, H., Katsnelson, L. B., Solovyova, O., Markhasin, V. S., & Panfilov, A. (2014). Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture. PLOS ONE, 9(5).
Chicago author-date
Pravdin, Sergei, Hans Dierckx, Leonid B Katsnelson, Olga Solovyova, Vladimir S Markhasin, and Alexander Panfilov. 2014. “Electrical Wave Propagation in an Anisotropic Model of the Left Ventricle Based on Analytical Description of Cardiac Architecture.” Plos One 9 (5).
Chicago author-date (all authors)
Pravdin, Sergei, Hans Dierckx, Leonid B Katsnelson, Olga Solovyova, Vladimir S Markhasin, and Alexander Panfilov. 2014. “Electrical Wave Propagation in an Anisotropic Model of the Left Ventricle Based on Analytical Description of Cardiac Architecture.” Plos One 9 (5).
Vancouver
1.
Pravdin S, Dierckx H, Katsnelson LB, Solovyova O, Markhasin VS, Panfilov A. Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture. PLOS ONE. 2014;9(5).
IEEE
[1]
S. Pravdin, H. Dierckx, L. B. Katsnelson, O. Solovyova, V. S. Markhasin, and A. Panfilov, “Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture,” PLOS ONE, vol. 9, no. 5, 2014.
@article{4410903,
  abstract     = {{We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher–Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation.}},
  articleno    = {{e93617}},
  author       = {{Pravdin, Sergei and Dierckx, Hans and Katsnelson, Leonid B and Solovyova, Olga and Markhasin, Vladimir S and Panfilov, Alexander}},
  issn         = {{1932-6203}},
  journal      = {{PLOS ONE}},
  keywords     = {{HEART,MYOCARDIUM,TISSUE MODEL,FIBER ROTATION,EXCITABLE MEDIUM,Filaments,Filament drift,Scroll waves,Wave propagation,Muscle tissue,Heart,Fibers,Endocardium,Epicardium,Mathematical physiology,Left ventricle,REENTRY,FIBRILLATION,ACTIVATION,MECHANISMS,VORTICES}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{15}},
  title        = {{Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0093617}},
  volume       = {{9}},
  year         = {{2014}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: