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The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours

(2014) INTERNATIONAL JOURNAL OF ONCOLOGY. 44(4). p.1015-1022
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Abstract
Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells (LPCs) are bipotential stem cells activated in case of severe liver damage and are capable of forming both cholangiocytes and hepatocytes. Possibly, alterations in Wnt, transforming growth factor-, Notch and hypoxia pathways in these LPCs can cause them to give rise to cancer stem cells, capable of driving tumourigenesis. In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis.
Keywords
CANCER STEM-CELLS, hypoxia inducible factor 1, REGENERATION, MICE, DRUG-RESISTANCE, IN-VIVO, CHOLANGIOCARCINOMA, INDUCIBLE FACTOR, SIGNALING PATHWAYS, EPITHELIAL-MESENCHYMAL TRANSITION, HEPATOCELLULAR-CARCINOMA CELLS, hepatic cancer, liver progenitor cell, cancer stem cells, Wnt receptors, TGF-, Notch receptors

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Citation

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Chicago
Bogaerts, Eliene, Femke Heindryckx, Yves-Paul Vandewynckel, Leo A Van Grunsven, and Hans Van Vlierberghe. 2014. “The Roles of Transforming Growth Factor-β, Wnt, Notch and Hypoxia on Liver Progenitor Cells in Primary Liver Tumours.” International Journal of Oncology 44 (4): 1015–1022.
APA
Bogaerts, Eliene, Heindryckx, F., Vandewynckel, Y.-P., Van Grunsven, L. A., & Van Vlierberghe, H. (2014). The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours. INTERNATIONAL JOURNAL OF ONCOLOGY, 44(4), 1015–1022.
Vancouver
1.
Bogaerts E, Heindryckx F, Vandewynckel Y-P, Van Grunsven LA, Van Vlierberghe H. The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours. INTERNATIONAL JOURNAL OF ONCOLOGY. 2014;44(4):1015–22.
MLA
Bogaerts, Eliene, Femke Heindryckx, Yves-Paul Vandewynckel, et al. “The Roles of Transforming Growth Factor-β, Wnt, Notch and Hypoxia on Liver Progenitor Cells in Primary Liver Tumours.” INTERNATIONAL JOURNAL OF ONCOLOGY 44.4 (2014): 1015–1022. Print.
@article{4403753,
  abstract     = {Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells (LPCs) are bipotential stem cells activated in case of severe liver damage and are capable of forming both cholangiocytes and hepatocytes. Possibly, alterations in Wnt, transforming growth factor-, Notch and hypoxia pathways in these LPCs can cause them to give rise to cancer stem cells, capable of driving tumourigenesis. In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis.},
  author       = {Bogaerts, Eliene and Heindryckx, Femke and Vandewynckel, Yves-Paul and Van Grunsven, Leo A and Van Vlierberghe, Hans},
  issn         = {1019-6439},
  journal      = {INTERNATIONAL JOURNAL OF ONCOLOGY},
  language     = {eng},
  number       = {4},
  pages        = {1015--1022},
  title        = {The roles of transforming growth factor-\ensuremath{\beta}, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours},
  url          = {http://dx.doi.org/10.3892/ijo.2014.2286},
  volume       = {44},
  year         = {2014},
}

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