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Recent advances in oral vaccine development: yeast-derived β-glucan particles

Rebecca De Smet (UGent) , Liesbeth Allais (UGent) and Claude Cuvelier (UGent)
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Abstract
Oral vaccination is the most challenging vaccination method due to the administration route. However, oral vaccination has socio-economic benefits and provides the possibility of stimulating both humoral and cellular immune responses at systemic and mucosal sites. Despite the advantages of oral vaccination, only a limited number of oral vaccines are currently approved for human use. During the last decade, extensive research regarding antigen-based oral vaccination methods have improved immunogenicity and induced desired immunological outcomes. Nevertheless, several factors such as the harsh gastro-intestinal environment and oral tolerance impede the clinical application of oral delivery systems. To date, human clinical trials investigating the efficacy of these systems are still lacking. This review addresses the rationale and key biological and physicochemical aspects of oral vaccine design and highlights the use of yeast-derived β-glucan microparticles as an oral vaccine delivery platform.
Keywords
Peyer's patches, GALT, yeast-derived beta-glucan, microparticles, antigen delivery vehicles, oral, vaccination, BINDING LECTIN SITE, PH-SENSITIVE NANOPARTICLES, NECROSIS-FACTOR-ALPHA, VIRUS-LIKE PARTICLES, INTESTINAL M-CELLS, DENDRITIC CELLS, CROSS-PRESENTATION, IMMUNE-RESPONSE, PEYERS-PATCHES, BIODEGRADABLE NANOPARTICLES

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Citation

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Chicago
De Smet, Rebecca, Liesbeth Allais, and Claude Cuvelier. 2014. “Recent Advances in Oral Vaccine Development: Yeast-derived Β-glucan Particles.” Human Vaccines & Immunotherapeutics 10 (5): 1309–1318.
APA
De Smet, Rebecca, Allais, L., & Cuvelier, C. (2014). Recent advances in oral vaccine development: yeast-derived β-glucan particles. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 10(5), 1309–1318.
Vancouver
1.
De Smet R, Allais L, Cuvelier C. Recent advances in oral vaccine development: yeast-derived β-glucan particles. HUMAN VACCINES & IMMUNOTHERAPEUTICS. 2014;10(5):1309–18.
MLA
De Smet, Rebecca, Liesbeth Allais, and Claude Cuvelier. “Recent Advances in Oral Vaccine Development: Yeast-derived Β-glucan Particles.” HUMAN VACCINES & IMMUNOTHERAPEUTICS 10.5 (2014): 1309–1318. Print.
@article{4398965,
  abstract     = {Oral vaccination is the most challenging vaccination method due to the administration route. However, oral vaccination has socio-economic benefits and provides the possibility of stimulating both humoral and cellular immune responses at systemic and mucosal sites. Despite the advantages of oral vaccination, only a limited number of oral vaccines are currently approved for human use. During the last decade, extensive research regarding antigen-based oral vaccination methods have improved immunogenicity and induced desired immunological outcomes. Nevertheless, several factors such as the harsh gastro-intestinal environment and oral tolerance impede the clinical application of oral delivery systems. To date, human clinical trials investigating the efficacy of these systems are still lacking. This review addresses the rationale and key biological and physicochemical aspects of oral vaccine design and highlights the use of yeast-derived β-glucan microparticles as an oral vaccine delivery platform.},
  author       = {De Smet, Rebecca and Allais, Liesbeth and Cuvelier, Claude},
  issn         = {2164-5515},
  journal      = {HUMAN VACCINES & IMMUNOTHERAPEUTICS},
  keywords     = {Peyer's patches,GALT,yeast-derived beta-glucan,microparticles,antigen delivery vehicles,oral,vaccination,BINDING LECTIN SITE,PH-SENSITIVE NANOPARTICLES,NECROSIS-FACTOR-ALPHA,VIRUS-LIKE PARTICLES,INTESTINAL M-CELLS,DENDRITIC CELLS,CROSS-PRESENTATION,IMMUNE-RESPONSE,PEYERS-PATCHES,BIODEGRADABLE NANOPARTICLES},
  language     = {eng},
  number       = {5},
  pages        = {1309--1318},
  title        = {Recent advances in oral vaccine development: yeast-derived β-glucan particles},
  url          = {http://dx.doi.org/10.4161/hv.28166},
  volume       = {10},
  year         = {2014},
}

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