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Base excision repair and its role in maintaining genome stability

Joke Baute UGent and Anna Depicker UGent (2008) CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 43(4). p.239-276
abstract
For all living organisms, genome stability is important, but is also under constant threat because various environmental and endogenous damaging agents can modify the structural properties of DNA bases. As a defense, organisms have developed different DNA repair pathways. Base excision repair (BER) is the predominant pathway for coping with a broad range of small lesions resulting from oxidation, alkylation, and deamination, which modify individual bases without large effect on the double helix structure. As, in mammalian cells, this damage is estimated to account daily for 104 events per cell, the need for BER pathways is unquestionable. The damage-specific removal is carried out by a considerable group of enzymes, designated as DNA glycosylases. Each DNA glycosylase has its unique specificity and many of them are ubiquitous in microorganisms, mammals, and plants. Here, we review the importance of the BER pathway and we focus on the different roles of DNA glycosylases in various organisms.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
DNA repair, DNA glycosylase, DNA damage, mutagenesis, URACIL-DNA-GLYCOSYLASE, COLI ENDONUCLEASE-III, CELL NUCLEAR ANTIGEN, OXIDATIVELY DAMAGED DNA, P53 TUMOR-SUPPRESSOR, DOUBLE-STRANDED DNA, GUANOSINE LESIONS SPIROIMINODIHYDANTOIN, SENSOR RAD9-RAD1-HUS1 INTERACTS, HUMAN ALKYLADENINE GLYCOSYLASE, BROAD SUBSTRATE-SPECIFICITY
journal title
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Crit. Rev. Biochem. Mol. Biol.
volume
43
issue
4
pages
239 - 276
Web of Science type
Review
Web of Science id
000258774400001
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
8.306 (2008)
JCR rank
25/276 (2008)
JCR quartile
1 (2008)
ISSN
1040-9238
DOI
10.1080/10409230802309905
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
439471
handle
http://hdl.handle.net/1854/LU-439471
date created
2008-11-12 13:58:00
date last changed
2012-12-05 17:25:47
@article{439471,
  abstract     = {For all living organisms, genome stability is important, but is also under constant threat because various environmental and endogenous damaging agents can modify the structural properties of DNA bases. As a defense, organisms have developed different DNA repair pathways. Base excision repair (BER) is the predominant pathway for coping with a broad range of small lesions resulting from oxidation, alkylation, and deamination, which modify individual bases without large effect on the double helix structure. As, in mammalian cells, this damage is estimated to account daily for 104 events per cell, the need for BER pathways is unquestionable. The damage-specific removal is carried out by a considerable group of enzymes, designated as DNA glycosylases. Each DNA glycosylase has its unique specificity and many of them are ubiquitous in microorganisms, mammals, and plants. Here, we review the importance of the BER pathway and we focus on the different roles of DNA glycosylases in various organisms.},
  author       = {Baute, Joke and Depicker, Anna},
  issn         = {1040-9238},
  journal      = {CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY},
  keyword      = {DNA repair,DNA glycosylase,DNA damage,mutagenesis,URACIL-DNA-GLYCOSYLASE,COLI ENDONUCLEASE-III,CELL NUCLEAR ANTIGEN,OXIDATIVELY DAMAGED DNA,P53 TUMOR-SUPPRESSOR,DOUBLE-STRANDED DNA,GUANOSINE LESIONS SPIROIMINODIHYDANTOIN,SENSOR RAD9-RAD1-HUS1 INTERACTS,HUMAN ALKYLADENINE GLYCOSYLASE,BROAD SUBSTRATE-SPECIFICITY},
  language     = {eng},
  number       = {4},
  pages        = {239--276},
  title        = {Base excision repair and its role in maintaining genome stability},
  url          = {http://dx.doi.org/10.1080/10409230802309905},
  volume       = {43},
  year         = {2008},
}

Chicago
Baute, Joke, and Anna Depicker. 2008. “Base Excision Repair and Its Role in Maintaining Genome Stability.” Critical Reviews in Biochemistry and Molecular Biology 43 (4): 239–276.
APA
Baute, J., & Depicker, A. (2008). Base excision repair and its role in maintaining genome stability. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 43(4), 239–276.
Vancouver
1.
Baute J, Depicker A. Base excision repair and its role in maintaining genome stability. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2008;43(4):239–76.
MLA
Baute, Joke, and Anna Depicker. “Base Excision Repair and Its Role in Maintaining Genome Stability.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 43.4 (2008): 239–276. Print.