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Base excision repair and its role in maintaining genome stability

Joke Baute (UGent) and Anna Depicker (UGent)
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Abstract
For all living organisms, genome stability is important, but is also under constant threat because various environmental and endogenous damaging agents can modify the structural properties of DNA bases. As a defense, organisms have developed different DNA repair pathways. Base excision repair (BER) is the predominant pathway for coping with a broad range of small lesions resulting from oxidation, alkylation, and deamination, which modify individual bases without large effect on the double helix structure. As, in mammalian cells, this damage is estimated to account daily for 104 events per cell, the need for BER pathways is unquestionable. The damage-specific removal is carried out by a considerable group of enzymes, designated as DNA glycosylases. Each DNA glycosylase has its unique specificity and many of them are ubiquitous in microorganisms, mammals, and plants. Here, we review the importance of the BER pathway and we focus on the different roles of DNA glycosylases in various organisms.
Keywords
DNA repair, DNA glycosylase, DNA damage, mutagenesis, URACIL-DNA-GLYCOSYLASE, COLI ENDONUCLEASE-III, CELL NUCLEAR ANTIGEN, OXIDATIVELY DAMAGED DNA, P53 TUMOR-SUPPRESSOR, DOUBLE-STRANDED DNA, GUANOSINE LESIONS SPIROIMINODIHYDANTOIN, SENSOR RAD9-RAD1-HUS1 INTERACTS, HUMAN ALKYLADENINE GLYCOSYLASE, BROAD SUBSTRATE-SPECIFICITY

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Citation

Please use this url to cite or link to this publication:

MLA
Baute, Joke, and Anna Depicker. “Base Excision Repair and Its Role in Maintaining Genome Stability.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 43.4 (2008): 239–276. Print.
APA
Baute, J., & Depicker, A. (2008). Base excision repair and its role in maintaining genome stability. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 43(4), 239–276.
Chicago author-date
Baute, Joke, and Anna Depicker. 2008. “Base Excision Repair and Its Role in Maintaining Genome Stability.” Critical Reviews in Biochemistry and Molecular Biology 43 (4): 239–276.
Chicago author-date (all authors)
Baute, Joke, and Anna Depicker. 2008. “Base Excision Repair and Its Role in Maintaining Genome Stability.” Critical Reviews in Biochemistry and Molecular Biology 43 (4): 239–276.
Vancouver
1.
Baute J, Depicker A. Base excision repair and its role in maintaining genome stability. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2008;43(4):239–76.
IEEE
[1]
J. Baute and A. Depicker, “Base excision repair and its role in maintaining genome stability,” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 43, no. 4, pp. 239–276, 2008.
@article{439471,
  abstract     = {For all living organisms, genome stability is important, but is also under constant threat because various environmental and endogenous damaging agents can modify the structural properties of DNA bases. As a defense, organisms have developed different DNA repair pathways. Base excision repair (BER) is the predominant pathway for coping with a broad range of small lesions resulting from oxidation, alkylation, and deamination, which modify individual bases without large effect on the double helix structure. As, in mammalian cells, this damage is estimated to account daily for 104 events per cell, the need for BER pathways is unquestionable. The damage-specific removal is carried out by a considerable group of enzymes, designated as DNA glycosylases. Each DNA glycosylase has its unique specificity and many of them are ubiquitous in microorganisms, mammals, and plants. Here, we review the importance of the BER pathway and we focus on the different roles of DNA glycosylases in various organisms.},
  author       = {Baute, Joke and Depicker, Anna},
  issn         = {1040-9238},
  journal      = {CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY},
  keywords     = {DNA repair,DNA glycosylase,DNA damage,mutagenesis,URACIL-DNA-GLYCOSYLASE,COLI ENDONUCLEASE-III,CELL NUCLEAR ANTIGEN,OXIDATIVELY DAMAGED DNA,P53 TUMOR-SUPPRESSOR,DOUBLE-STRANDED DNA,GUANOSINE LESIONS SPIROIMINODIHYDANTOIN,SENSOR RAD9-RAD1-HUS1 INTERACTS,HUMAN ALKYLADENINE GLYCOSYLASE,BROAD SUBSTRATE-SPECIFICITY},
  language     = {eng},
  number       = {4},
  pages        = {239--276},
  title        = {Base excision repair and its role in maintaining genome stability},
  url          = {http://dx.doi.org/10.1080/10409230802309905},
  volume       = {43},
  year         = {2008},
}

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