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Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases

Grigoris Amoutzias (UGent) , Yves Van de Peer (UGent) and Dimitris Mossialos
(2008) FUTURE MICROBIOLOGY. 3(3). p.361-370
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Abstract
The majority of nonribosomal peptide synthases and type I polyketide synthases are multimodular megasynthases of oligopeptide and polyketide secondary metabolites, respectively. Owing to their multimodular architecture, they synthesize their metabolites in assembly line logic. The ongoing genomic revolution together with the application of computational tools has provided the opportunity to mine the various genomes for these enzymes and identify those organisms that produce many oligopeptide and polyketide metabolites. In addition, scientists have started to comprehend the molecular mechanisms of megasynthase evolution, by duplication, recombination, point mutation and module skipping. This knowledge and computational analyses have been implemented towards predicting the specificity of these megasynthases and the structure of their end products. It is an exciting field, both for gaining deeper insight into their basic molecular mechanisms and exploiting them biotechnologically.
Keywords
bioinformatics, antibiotics, distribution, evolution, nonribosomal peptide synthase, NRPS, PKS, polyketide synthase, prediction, siderophores, ADENYLATION DOMAINS, PHYLOGENETIC ANALYSIS, MULTIDOMAIN PROTEINS, CONDENSATION DOMAINS, SEQUENCE ALIGNMENTS, MEDIATING DOMAINS, SPECIFICITY, BIOSYNTHESIS, SYNTHETASES, GENE-CLUSTER

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Citation

Please use this url to cite or link to this publication:

MLA
Amoutzias, Grigoris, Yves Van de Peer, and Dimitris Mossialos. “Evolution and Taxonomic Distribution of Nonribosomal Peptide and Polyketide Synthases.” FUTURE MICROBIOLOGY 3.3 (2008): 361–370. Print.
APA
Amoutzias, G., Van de Peer, Y., & Mossialos, D. (2008). Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases. FUTURE MICROBIOLOGY, 3(3), 361–370.
Chicago author-date
Amoutzias, Grigoris, Yves Van de Peer, and Dimitris Mossialos. 2008. “Evolution and Taxonomic Distribution of Nonribosomal Peptide and Polyketide Synthases.” Future Microbiology 3 (3): 361–370.
Chicago author-date (all authors)
Amoutzias, Grigoris, Yves Van de Peer, and Dimitris Mossialos. 2008. “Evolution and Taxonomic Distribution of Nonribosomal Peptide and Polyketide Synthases.” Future Microbiology 3 (3): 361–370.
Vancouver
1.
Amoutzias G, Van de Peer Y, Mossialos D. Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases. FUTURE MICROBIOLOGY. 2008;3(3):361–70.
IEEE
[1]
G. Amoutzias, Y. Van de Peer, and D. Mossialos, “Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases,” FUTURE MICROBIOLOGY, vol. 3, no. 3, pp. 361–370, 2008.
@article{439454,
  abstract     = {The majority of nonribosomal peptide synthases and type I polyketide synthases are multimodular megasynthases of oligopeptide and polyketide secondary metabolites, respectively. Owing to their multimodular architecture, they synthesize their metabolites in assembly line logic. The ongoing genomic revolution together with the application of computational tools has provided the opportunity to mine the various genomes for these enzymes and identify those organisms that produce many oligopeptide and polyketide metabolites. In addition, scientists have started to comprehend the molecular mechanisms of megasynthase evolution, by duplication, recombination, point mutation and module skipping. This knowledge and computational analyses have been implemented towards predicting the specificity of these megasynthases and the structure of their end products. It is an exciting field, both for gaining deeper insight into their basic molecular mechanisms and exploiting them biotechnologically.},
  author       = {Amoutzias, Grigoris and Van de Peer, Yves and Mossialos, Dimitris},
  issn         = {1746-0913},
  journal      = {FUTURE MICROBIOLOGY},
  keywords     = {bioinformatics,antibiotics,distribution,evolution,nonribosomal peptide synthase,NRPS,PKS,polyketide synthase,prediction,siderophores,ADENYLATION DOMAINS,PHYLOGENETIC ANALYSIS,MULTIDOMAIN PROTEINS,CONDENSATION DOMAINS,SEQUENCE ALIGNMENTS,MEDIATING DOMAINS,SPECIFICITY,BIOSYNTHESIS,SYNTHETASES,GENE-CLUSTER},
  language     = {eng},
  number       = {3},
  pages        = {361--370},
  title        = {Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases},
  url          = {http://dx.doi.org/10.2217/17460913.3.3.361},
  volume       = {3},
  year         = {2008},
}
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