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The PRA1 gene family in Arabidopsis

Claire Lessa Alvim Kamei (UGent) , Joanna Boruc (UGent) , Klaas Vandepoele (UGent) , Hilde Van Den Daele (UGent) , Sara Maes (UGent) , Eugenia Russinova (UGent) , Dirk Inzé (UGent) and Lieven De Veylder (UGent)
(2008) PLANT PHYSIOLOGY. 147(4). p.1735-1749
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Organization
Abstract
Prenylated Rab acceptor 1 (PRA1) domain proteins are small transmembrane proteins that regulate vesicle trafficking as receptors of Rab GTPases and the vacuolar soluble N-ethylmaleimide-sensitive factor attachment receptor protein VAMP2. However, little is known about PRA1 family members in plants. Sequence analysis revealed that higher plants, compared with animals and primitive plants, possess an expanded family of PRA1 domain-containing proteins. The Arabidopsis ( Arabidopsis thaliana) PRA1 (AtPRA1) proteins were found to homodimerize and heterodimerize in a manner corresponding to their phylogenetic distribution. Different AtPRA1 family members displayed distinct expression patterns, with a preference for vascular cells and expanding or developing tissues. AtPRA1 genes were significantly coexpressed with Rab GTPases and genes encoding vesicle transport proteins, suggesting an involvement in the vesicle trafficking process similar to that of their animal counterparts. Correspondingly, AtPRA1 proteins were localized in the endoplasmic reticulum, Golgi apparatus, and endosomes/prevacuolar compartments, hinting at a function in both secretory and endocytic intracellular trafficking pathways. Taken together, our data reveal a high functional diversity of AtPRA1 proteins, probably dealing with the various demands of the complex trafficking system.
Keywords
GOLGI-COMPLEX, SMALL GTPASES, DOMAIN FAMILY, MEMBER-2 PRAF2, SECRETORY TRAFFICKING, ENDOPLASMIC-RETICULUM, DISTINCT MEMBRANE COMPARTMENTS, PRENYLATED RAB ACCEPTOR, PROTEIN, TRANSPORT

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Chicago
Lessa Alvim Kamei, Claire, Joanna Boruc, Klaas Vandepoele, Hilde Van Den Daele, Sara Maes, Eugenia Russinova, Dirk Inzé, and Lieven De Veylder. 2008. “The PRA1 Gene Family in Arabidopsis.” Plant Physiology 147 (4): 1735–1749.
APA
Lessa Alvim Kamei, C., Boruc, J., Vandepoele, K., Van Den Daele, H., Maes, S., Russinova, E., Inzé, D., et al. (2008). The PRA1 gene family in Arabidopsis. PLANT PHYSIOLOGY, 147(4), 1735–1749.
Vancouver
1.
Lessa Alvim Kamei C, Boruc J, Vandepoele K, Van Den Daele H, Maes S, Russinova E, et al. The PRA1 gene family in Arabidopsis. PLANT PHYSIOLOGY. 2008;147(4):1735–49.
MLA
Lessa Alvim Kamei, Claire, Joanna Boruc, Klaas Vandepoele, et al. “The PRA1 Gene Family in Arabidopsis.” PLANT PHYSIOLOGY 147.4 (2008): 1735–1749. Print.
@article{438876,
  abstract     = {Prenylated Rab acceptor 1 (PRA1) domain proteins are small transmembrane proteins that regulate vesicle trafficking as receptors of Rab GTPases and the vacuolar soluble N-ethylmaleimide-sensitive factor attachment receptor protein VAMP2. However, little is known about PRA1 family members in plants. Sequence analysis revealed that higher plants, compared with animals and primitive plants, possess an expanded family of PRA1 domain-containing proteins. The Arabidopsis ( Arabidopsis thaliana) PRA1 (AtPRA1) proteins were found to homodimerize and heterodimerize in a manner corresponding to their phylogenetic distribution. Different AtPRA1 family members displayed distinct expression patterns, with a preference for vascular cells and expanding or developing tissues. AtPRA1 genes were significantly coexpressed with Rab GTPases and genes encoding vesicle transport proteins, suggesting an involvement in the vesicle trafficking process similar to that of their animal counterparts. Correspondingly, AtPRA1 proteins were localized in the endoplasmic reticulum, Golgi apparatus, and endosomes/prevacuolar compartments, hinting at a function in both secretory and endocytic intracellular trafficking pathways. Taken together, our data reveal a high functional diversity of AtPRA1 proteins, probably dealing with the various demands of the complex trafficking system.},
  author       = {Lessa Alvim Kamei, Claire and Boruc, Joanna and Vandepoele, Klaas and Van Den Daele, Hilde and Maes, Sara and Russinova, Eugenia and Inz{\'e}, Dirk and De Veylder, Lieven},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  language     = {eng},
  number       = {4},
  pages        = {1735--1749},
  title        = {The PRA1 gene family in Arabidopsis},
  url          = {http://dx.doi.org/10.1104/pp.108.122226},
  volume       = {147},
  year         = {2008},
}

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