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Choose your partners: dimerization in eukaryotic transcription factors

Grigoris Amoutzias UGent, David L Robertson, Yves Van de Peer UGent and Stephen G Oliver (2008) TRENDS IN BIOCHEMICAL SCIENCES. 33(5). p.220-229
abstract
In many eukaryotic transcription factor gene families, proteins require a physical interaction with an identical molecule or with another molecule within the same family to form a functional dimer and bind DNA. Depending on the choice of partner and the cellular context, each dimer triggers a sequence of regulatory events that lead to a particular cellular fate, for example, proliferation or differentiation. Recent syntheses of genomic and functional data reveal that partner choice is not random; instead, dimerization specificities, which are strongly linked to the evolution of the protein family, apply. Our focus is on understanding these interaction specificities, their functional consequences and how they evolved. This knowledge is essential for understanding gene regulation and designing a new generation of drugs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
NF-KAPPA-B, PROTEIN-PROTEIN INTERACTION, DNA-BINDING SITE, INTERACTION NETWORKS, GENE FAMILY, NUCLEAR RECEPTORS, COMPLEX-FORMATION, IN-VITRO, EVOLUTION, ARABIDOPSIS
journal title
TRENDS IN BIOCHEMICAL SCIENCES
Trends Biochem.Sci.
volume
33
issue
5
pages
220 - 229
Web of Science type
Review
Web of Science id
000256750100005
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
14.101 (2008)
JCR rank
12/276 (2008)
JCR quartile
1 (2008)
ISSN
0968-0004
DOI
10.1016/j.tibs.2008.02.002
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
438837
handle
http://hdl.handle.net/1854/LU-438837
date created
2008-11-07 16:52:00
date last changed
2012-12-05 16:07:38
@article{438837,
  abstract     = {In many eukaryotic transcription factor gene families, proteins require a physical interaction with an identical molecule or with another molecule within the same family to form a functional dimer and bind DNA. Depending on the choice of partner and the cellular context, each dimer triggers a sequence of regulatory events that lead to a particular cellular fate, for example, proliferation or differentiation. Recent syntheses of genomic and functional data reveal that partner choice is not random; instead, dimerization specificities, which are strongly linked to the evolution of the protein family, apply. Our focus is on understanding these interaction specificities, their functional consequences and how they evolved. This knowledge is essential for understanding gene regulation and designing a new generation of drugs.},
  author       = {Amoutzias, Grigoris and Robertson, David L and Van de Peer, Yves and Oliver, Stephen G},
  issn         = {0968-0004},
  journal      = {TRENDS IN BIOCHEMICAL SCIENCES},
  keyword      = {NF-KAPPA-B,PROTEIN-PROTEIN INTERACTION,DNA-BINDING SITE,INTERACTION NETWORKS,GENE FAMILY,NUCLEAR RECEPTORS,COMPLEX-FORMATION,IN-VITRO,EVOLUTION,ARABIDOPSIS},
  language     = {eng},
  number       = {5},
  pages        = {220--229},
  title        = {Choose your partners: dimerization in eukaryotic transcription factors},
  url          = {http://dx.doi.org/10.1016/j.tibs.2008.02.002},
  volume       = {33},
  year         = {2008},
}

Chicago
Amoutzias, Grigoris, David L Robertson, Yves Van de Peer, and Stephen G Oliver. 2008. “Choose Your Partners: Dimerization in Eukaryotic Transcription Factors.” Trends in Biochemical Sciences 33 (5): 220–229.
APA
Amoutzias, G., Robertson, D. L., Van de Peer, Y., & Oliver, S. G. (2008). Choose your partners: dimerization in eukaryotic transcription factors. TRENDS IN BIOCHEMICAL SCIENCES, 33(5), 220–229.
Vancouver
1.
Amoutzias G, Robertson DL, Van de Peer Y, Oliver SG. Choose your partners: dimerization in eukaryotic transcription factors. TRENDS IN BIOCHEMICAL SCIENCES. 2008;33(5):220–9.
MLA
Amoutzias, Grigoris, David L Robertson, Yves Van de Peer, et al. “Choose Your Partners: Dimerization in Eukaryotic Transcription Factors.” TRENDS IN BIOCHEMICAL SCIENCES 33.5 (2008): 220–229. Print.