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A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study

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Abstract
To develop age-, sex-, and ethnic-appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world. The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 1880 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age. This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity.
Keywords
REAL-TIME, LEFT-VENTRICULAR MASS, DIASTOLIC FUNCTION, SYSTOLIC DYSFUNCTION, GENERAL-POPULATION, LEFT ATRIAL VOLUME, HEALTHY JAPANESE POPULATION, ANGIOTENSIN-CONVERTING-ENZYME, TWO-DIMENSIONAL ECHOCARDIOGRAPHY, Meta-analysis, Echocardiography, Reference ranges, ANATOMIC VALIDATION

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Please use this url to cite or link to this publication:

Chicago
Doughty, RN, JM Gardin, FDR Hobbs, JJV McMurray, SF Nagueh, KK Poppe, R Senior, et al. 2014. “A Meta-analysis of Echocardiographic Measurements of the Left Heart for the Development of Normative Reference Ranges in a Large International Cohort: The EchoNoRMAL Study.” European Heart Journal-cardiovascular Imaging 15 (3): 341–348.
APA
Doughty, R., Gardin, J., Hobbs, F., McMurray, J., Nagueh, S., Poppe, K., Senior, R., et al. (2014). A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 15(3), 341–348.
Vancouver
1.
Doughty R, Gardin J, Hobbs F, McMurray J, Nagueh S, Poppe K, et al. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING. 2014;15(3):341–8.
MLA
Doughty, RN, JM Gardin, FDR Hobbs, et al. “A Meta-analysis of Echocardiographic Measurements of the Left Heart for the Development of Normative Reference Ranges in a Large International Cohort: The EchoNoRMAL Study.” EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING 15.3 (2014): 341–348. Print.
@article{4387504,
  abstract     = {To develop age-, sex-, and ethnic-appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world.
The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 1880 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age.
This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity.},
  author       = {Doughty, RN and Gardin, JM and Hobbs, FDR and McMurray, JJV and Nagueh, SF and Poppe, KK and Senior, R and Thomas, L and Whalley, GA and Aune, E and Brown, A and Badano, LP and Cameron, V and Chadha, DS and Chahal, N and Chien, KL and Daimon, M and Dalen, H and Detrano, R and Duzenli, MA and Ezekowitz, J and de Simone, G and Di Pasquale, P and Fukuda, S and Gill, PS and Grossman, E and Kim, HK and Kuznetsova, T and Leung, NKW and Linhart, A and McDonagh, TA and McGrady, M and Mill, JG and Mogelvang, R and Muiesan, ML and Ng, ACT and Ojji, D and Otterstad, JE and Petrovic, DJ and Prendergast, B and Rietzschel, Ernst and Schirmer, H and Schvartzman, P and Simova, I and Sliwa, K and Stewart, S and Squire, IB and Takeuchi, M and Altman, D and Perera, R and Triggs, CM and Yeung, HA and Picn, GAB and Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) Collaboration, the and Chirinos Medina, Julio and De Buyzere, Marc and Gillebert, Thierry and Segers, Patrick and Van daele, Caroline},
  issn         = {2047-2404},
  journal      = {EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING},
  keyword      = {REAL-TIME,LEFT-VENTRICULAR MASS,DIASTOLIC FUNCTION,SYSTOLIC DYSFUNCTION,GENERAL-POPULATION,LEFT ATRIAL VOLUME,HEALTHY JAPANESE POPULATION,ANGIOTENSIN-CONVERTING-ENZYME,TWO-DIMENSIONAL ECHOCARDIOGRAPHY,Meta-analysis,Echocardiography,Reference ranges,ANATOMIC VALIDATION},
  language     = {eng},
  number       = {3},
  pages        = {341--348},
  title        = {A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study},
  url          = {http://dx.doi.org/10.1093/ehjci/jet240},
  volume       = {15},
  year         = {2014},
}

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