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Expression of the sFLT1 gene in cord blood cells is associated to maternal arsenic exposure and decreased birth weight

(2014) PLOS ONE. 9(3).
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Abstract
There is increasing epidemiologic evidence that arsenic exposure in utero is associated with adverse pregnancy outcomes and may contribute to long-term health effects. These effects may occur at low environmental exposures but the underlying molecular mechanism is not clear. We collected cord blood samples of 183 newborns to identify associations between arsenic levels and birth anthropometric parameters in an area with very low arsenic exposure. Our core research aim was to screen for transcriptional marks that mechanistically explain these associations. Multiple regression analyses showed that birth weight decreased with 47 g (95% CI: 16-78 g) for an interquartile range increase of 0.99 mg/L arsenic. The model was adjusted for child's sex, maternal smoking during pregnancy, gestational age, and parity. Higher arsenic concentrations and reduced birth weight were positively associated with changes in expression of the sFLT1 (soluble fms-like tyrosine kinase-1) gene in cord blood cells in girls. The protein product of sFLT1 is a scavenger of vascular endothelial growth factor (VEGF) in the extracellular environment and plays a key role in the inhibition of placental angiogenesis. In terms of fetal development, inhibition of placental angiogenesis leads to impaired nutrition and hence to growth retardation. Various genes related to DNA methylation and oxidative stress showed also changed expression in relation to arsenic exposure but were not related to birth outcome parameters. In conclusion, this study suggests that increased expression of sFLT1 is an intermediate marker that points to placental angiogenesis as a pathway linking prenatal arsenic exposure to reduced birth weight.
Keywords
DNA METHYLATION, GROWTH-FACTOR RECEPTOR-1, REACTIVE OXYGEN, ENDOTHELIAL-CELLS, OXIDATIVE STRESS, HUMAN PLACENTA, HYPERTENSION, CHINESE, DISEASE, VASCULOGENESIS

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Chicago
Remy, Sylvie, Eva Govarts, Liesbeth Bruckers, Melissa Paulussen, Britt Wens, Elly Den Hond, Vera Nelen, et al. 2014. “Expression of the sFLT1 Gene in Cord Blood Cells Is Associated to Maternal Arsenic Exposure and Decreased Birth Weight.” Plos One 9 (3).
APA
Remy, Sylvie, Govarts, E., Bruckers, L., Paulussen, M., Wens, B., Den Hond, E., Nelen, V., et al. (2014). Expression of the sFLT1 gene in cord blood cells is associated to maternal arsenic exposure and decreased birth weight. PLOS ONE, 9(3).
Vancouver
1.
Remy S, Govarts E, Bruckers L, Paulussen M, Wens B, Den Hond E, et al. Expression of the sFLT1 gene in cord blood cells is associated to maternal arsenic exposure and decreased birth weight. PLOS ONE. 2014;9(3).
MLA
Remy, Sylvie, Eva Govarts, Liesbeth Bruckers, et al. “Expression of the sFLT1 Gene in Cord Blood Cells Is Associated to Maternal Arsenic Exposure and Decreased Birth Weight.” PLOS ONE 9.3 (2014): n. pag. Print.
@article{4374161,
  abstract     = {There is increasing epidemiologic evidence that arsenic exposure in utero is associated with adverse pregnancy outcomes and may contribute to long-term health effects. These effects may occur at low environmental exposures but the underlying molecular mechanism is not clear. We collected cord blood samples of 183 newborns to identify associations between arsenic levels and birth anthropometric parameters in an area with very low arsenic exposure. Our core research aim was to screen for transcriptional marks that mechanistically explain these associations. Multiple regression analyses showed that birth weight decreased with 47 g (95\% CI: 16-78 g) for an interquartile range increase of 0.99 mg/L arsenic. The model was adjusted for child's sex, maternal smoking during pregnancy, gestational age, and parity. Higher arsenic concentrations and reduced birth weight were positively associated with changes in expression of the sFLT1 (soluble fms-like tyrosine kinase-1) gene in cord blood cells in girls. The protein product of sFLT1 is a scavenger of vascular endothelial growth factor (VEGF) in the extracellular environment and plays a key role in the inhibition of placental angiogenesis. In terms of fetal development, inhibition of placental angiogenesis leads to impaired nutrition and hence to growth retardation. Various genes related to DNA methylation and oxidative stress showed also changed expression in relation to arsenic exposure but were not related to birth outcome parameters. In conclusion, this study suggests that increased expression of sFLT1 is an intermediate marker that points to placental angiogenesis as a pathway linking prenatal arsenic exposure to reduced birth weight.},
  articleno    = {e92677},
  author       = {Remy, Sylvie and Govarts, Eva and Bruckers, Liesbeth and Paulussen, Melissa and Wens, Britt and Den Hond, Elly and Nelen, Vera and Baeyens, Willy and Van Larebeke, Nicolas and Loots, Ilse and Sioen, Isabelle and Schoeters, Greet},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {DNA METHYLATION,GROWTH-FACTOR RECEPTOR-1,REACTIVE OXYGEN,ENDOTHELIAL-CELLS,OXIDATIVE STRESS,HUMAN PLACENTA,HYPERTENSION,CHINESE,DISEASE,VASCULOGENESIS},
  language     = {eng},
  number       = {3},
  pages        = {11},
  title        = {Expression of the sFLT1 gene in cord blood cells is associated to maternal arsenic exposure and decreased birth weight},
  url          = {http://dx.doi.org/10.1371/journal.pone.0092677},
  volume       = {9},
  year         = {2014},
}

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