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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) NATURE GENETICS. 45(9). p.984-996
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Abstract
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 +/- 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 +/- 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 +/- 0.06 s.e.), and ADHD and major depressive disorder (0.32 +/- 0.07 s.e.), low between schizophrenia and ASD (0.16 +/- 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Keywords
MAJOR DEPRESSIVE DISORDER, AUTISM SPECTRUM DISORDERS, DEFICIT HYPERACTIVITY DISORDER, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, COMMON SNPS, BIPOLAR DISORDER, CROHNS-DISEASE, SCHIZOPHRENIA, RISK, ASSOCIATION

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Chicago
Lee, SH, S Ripke, BM Neale, SV Faraone, SM Purcell, RH Perlis, BJ Mowry, et al. 2013. “Genetic Relationship Between Five Psychiatric Disorders Estimated from Genome-wide SNPs.” Nature Genetics 45 (9): 984–996.
APA
Lee, SH, Ripke, S., Neale, B., Faraone, S., Purcell, S., Perlis, R., Mowry, B., et al. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. NATURE GENETICS, 45(9), 984–996.
Vancouver
1.
Lee S, Ripke S, Neale B, Faraone S, Purcell S, Perlis R, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. NATURE GENETICS. 2013;45(9):984–96.
MLA
Lee, SH, S Ripke, BM Neale, et al. “Genetic Relationship Between Five Psychiatric Disorders Estimated from Genome-wide SNPs.” NATURE GENETICS 45.9 (2013): 984–996. Print.
@article{4369257,
  abstract     = {Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29\% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 +/- 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 +/- 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 +/- 0.06 s.e.), and ADHD and major depressive disorder (0.32 +/- 0.07 s.e.), low between schizophrenia and ASD (0.16 +/- 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.},
  author       = {Lee, SH and Ripke, S and Neale, BM and Faraone, SV and Purcell, SM and Perlis, RH and Mowry, BJ and Thapar, A and Goddard, ME and Witte, JS and Absher, D and Agartz, I and Akil, H and Amin, F and Andreassen, OA and Anjorin, A and Anney, R and Anttila, V and Arking, DE and Asherson, P and Azevedo, MH and Backlund, L and Badner, JA and Bailey, AJ and Banaschewski, T and Barchas, JD and Barnes, MR and Barrett, TB and Bass, N and Battaglia, A and Bauer, M and Bayes, M and Bellivier, F and Bergen, SE and Berrettini, W and Betancur, C and Bettecken, T and Biederman, J and Binder, EB and Black, DW and Blackwood, DHR and Bloss, CS and Boehnke, M and Boomsma, DI and Breen, G and Breuer, R and Bruggeman, R and Cormican, P and Buccola, NG and Buitelaar, JK and Bunney, WE and Buxbaum, JD and Byerley, WF and Byrne, EM and Caesar, S and Cahn, W and Cantor, RM and Casas, M and Chakravarti, A and Chambert, K and Choudhury, K and Cichon, S and Cloninger, CR and Collier, DA and Cook, 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  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  language     = {eng},
  number       = {9},
  pages        = {984--996},
  title        = {Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs},
  url          = {http://dx.doi.org/10.1038/ng.2711},
  volume       = {45},
  year         = {2013},
}

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