Advanced search
1 file | 1.31 MB Add to list

The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI

Author
Organization
Abstract
Preclinical imaging with SPECT combined with CT or MRI is used more and more frequently and has proven to be very useful in translational research. In this article, an overview of current preclinical research applications and trends of SPECT combined with CT or MRI, mainly in tumour imaging and neuroscience imaging, is given and the advan- tages and disadvantages of the different approaches are de- scribed. Today SPECT and CT systems are often integrated into a single device (commonly called a SPECT/CT system), whereas at present combined SPECT and MRI is almost always carried out with separate systems and fiducial markers to combine the separately acquired images. While preclinical SPECT/CT is most widely applied in oncology research, SPECT combined with MRI (SPECT/MRI when integrated in one system) offers the potential for both neuroscience applications and oncological applications. Today CT and MRI are still mainly used to localize radiotracer binding and to improve SPECT quantification, although both CT and MRI have additional potential. Future technology developments may include fast sequential or simultaneous acquisition of (dynamic) multimodality data, spectroscopy, fMRI along with high-resolution anatomic MRI, advanced CT procedures, and combinations of more than two modalities such as combina- tions of SPECT, PET, MRI and CT all together. This will all strongly depend on new technologies. With further advances in biology and chemistry for imaging molecular targets and (patho)physiological processes in vivo, the introduction of new imaging procedures and promising new radiopharmaceu- ticals in clinical practice may be accelerated.
Keywords
IN-VIVO, COMPUTED-TOMOGRAPHY, BETA-AMYLOID PLAQUES, D-2/3 RECEPTOR-BINDING, INDUCED DOPAMINE RELEASE, HIGH-RESOLUTION PINHOLE, SMALL-ANIMAL SPECT, PHOTON-EMISSION-TOMOGRAPHY, MICRO-CT, ATTENUATION CORRECTION

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.31 MB

Citation

Please use this url to cite or link to this publication:

MLA
Bernsen, Monique R., et al. “The Role of Preclinical SPECT in Oncological and Neurological Research in Combination with Either CT or MRI.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 41, no. 1, 2014, pp. 36–49.
APA
Bernsen, M. R., Vaissier, P. E., Van Holen, R., Booij, J., Beekman, F. J., & de Jong, M. (2014). The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 41(1), 36–49.
Chicago author-date
Bernsen, Monique R, Pieter EB Vaissier, Roel Van Holen, Jan Booij, Freek J Beekman, and Marion de Jong. 2014. “The Role of Preclinical SPECT in Oncological and Neurological Research in Combination with Either CT or MRI.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 (1): 36–49.
Chicago author-date (all authors)
Bernsen, Monique R, Pieter EB Vaissier, Roel Van Holen, Jan Booij, Freek J Beekman, and Marion de Jong. 2014. “The Role of Preclinical SPECT in Oncological and Neurological Research in Combination with Either CT or MRI.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 41 (1): 36–49.
Vancouver
1.
Bernsen MR, Vaissier PE, Van Holen R, Booij J, Beekman FJ, de Jong M. The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2014;41(1):36–49.
IEEE
[1]
M. R. Bernsen, P. E. Vaissier, R. Van Holen, J. Booij, F. J. Beekman, and M. de Jong, “The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI,” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 41, no. 1, pp. 36–49, 2014.
@article{4366857,
  abstract     = {Preclinical imaging with SPECT combined with CT or MRI is used more and more frequently and has proven to be very useful in translational research. In this article, an overview of current preclinical research applications and trends of SPECT combined with CT or MRI, mainly in tumour imaging and neuroscience imaging, is given and the advan- tages and disadvantages of the different approaches are de- scribed. Today SPECT and CT systems are often integrated into a single device (commonly called a SPECT/CT system), whereas at present combined SPECT and MRI is almost always carried out with separate systems and fiducial markers to combine the separately acquired images. While preclinical SPECT/CT is most widely applied in oncology research, SPECT combined with MRI (SPECT/MRI when integrated in one system) offers the potential for both neuroscience applications and oncological applications. Today CT and MRI are still mainly used to localize radiotracer binding and to improve SPECT quantification, although both CT and MRI have additional potential. Future technology developments may include fast sequential or simultaneous acquisition of (dynamic) multimodality data, spectroscopy, fMRI along with high-resolution anatomic MRI, advanced CT procedures, and combinations of more than two modalities such as combina- tions of SPECT, PET, MRI and CT all together. This will all strongly depend on new technologies. With further advances in biology and chemistry for imaging molecular targets and (patho)physiological processes in vivo, the introduction of new imaging procedures and promising new radiopharmaceu- ticals in clinical practice may be accelerated.},
  author       = {Bernsen, Monique R and Vaissier, Pieter EB and Van Holen, Roel and Booij, Jan and Beekman, Freek J and de Jong, Marion},
  issn         = {1619-7089},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keywords     = {IN-VIVO,COMPUTED-TOMOGRAPHY,BETA-AMYLOID PLAQUES,D-2/3 RECEPTOR-BINDING,INDUCED DOPAMINE RELEASE,HIGH-RESOLUTION PINHOLE,SMALL-ANIMAL SPECT,PHOTON-EMISSION-TOMOGRAPHY,MICRO-CT,ATTENUATION CORRECTION},
  language     = {eng},
  number       = {1},
  pages        = {36--49},
  title        = {The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI},
  url          = {http://dx.doi.org/10.1007/s00259-013-2685-3},
  volume       = {41},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: