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The influence of COMT Val158Met genotype on the character dimension cooperativeness in healthy females

Chris Baeken (UGent) , Stephan Claes and Rudi De Raedt (UGent)
(2014) BRAIN AND BEHAVIOR. 4(4). p.515-520
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Objectives: Although the Val(158)Met catechol-O-methyltransferase (COMT) gene has been linked with the temperament dimension Novelty Seeking (NS), new insights in this polymorphism might point to a major role for character features as well. Given that individual life experiences may influence Val(158) and Met(158) allele carriers differently it has been suggested that the character trait cooperativeness could be implicated. Case report: A homogeneous group of eighty right-handed Caucasian healthy female university students were assessed with the TCI and genotyped for the COMT Val(158)Met polymorphism (rs4680). Gene determination showed that eighteen were Val(158) homozygotes, forty-four Val/Met(158) heterozygotes, and eighteen were Met(158) homozygotes. All were within the same age range and never documented to have suffered from any neuropsychiatric illness. Bonferroni corrected non-parametric analyses showed that only for the character scale cooperativeness Val(158) homozygotes displayed significant higher scores when compared to Met(158) homozygotes. No significant differences on cooperativeness scores were found between Val(158) and Val/Met(158) carriers or between Met(158) and Val/Met(158) carriers. No differences were observed for the COMT Val(158) Met polymorphism and the other temperament and character scales. Conclusions: Our findings support the assumption that the Val(158)Met single nucleotide polymorphism (SNP) influences character traits and not only temperament. Our results add to the notion that Val(158) homozygotes are considered to be helpful and empathic and it suggest that these cooperativeness character traits are related to the dopaminergic system.
Keywords
DEPRESSION, ASSOCIATION, personality, BEHAVIOR, cooperativeness, SEX, AVERSIVE STIMULI, VAL158MET POLYMORPHISM, PERSONALITY-DISORDERS, O-METHYLTRANSFERASE COMT, PSYCHIATRIC-DISORDERS, Catechol-O-methyltransferase, GENE POLYMORPHISMS

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Citation

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MLA
Baeken, Chris, Stephan Claes, and Rudi De Raedt. “The Influence of COMT Val158Met Genotype on the Character Dimension Cooperativeness in Healthy Females.” BRAIN AND BEHAVIOR 4.4 (2014): 515–520. Print.
APA
Baeken, C., Claes, S., & De Raedt, R. (2014). The influence of COMT Val158Met genotype on the character dimension cooperativeness in healthy females. BRAIN AND BEHAVIOR, 4(4), 515–520.
Chicago author-date
Baeken, Chris, Stephan Claes, and Rudi De Raedt. 2014. “The Influence of COMT Val158Met Genotype on the Character Dimension Cooperativeness in Healthy Females.” Brain and Behavior 4 (4): 515–520.
Chicago author-date (all authors)
Baeken, Chris, Stephan Claes, and Rudi De Raedt. 2014. “The Influence of COMT Val158Met Genotype on the Character Dimension Cooperativeness in Healthy Females.” Brain and Behavior 4 (4): 515–520.
Vancouver
1.
Baeken C, Claes S, De Raedt R. The influence of COMT Val158Met genotype on the character dimension cooperativeness in healthy females. BRAIN AND BEHAVIOR. 2014;4(4):515–20.
IEEE
[1]
C. Baeken, S. Claes, and R. De Raedt, “The influence of COMT Val158Met genotype on the character dimension cooperativeness in healthy females,” BRAIN AND BEHAVIOR, vol. 4, no. 4, pp. 515–520, 2014.
@article{4364957,
  abstract     = {Objectives: Although the Val(158)Met catechol-O-methyltransferase (COMT) gene has been linked with the temperament dimension Novelty Seeking (NS), new insights in this polymorphism might point to a major role for character features as well. Given that individual life experiences may influence Val(158) and Met(158) allele carriers differently it has been suggested that the character trait cooperativeness could be implicated.
Case report: A homogeneous group of eighty right-handed Caucasian healthy female university students were assessed with the TCI and genotyped for the COMT Val(158)Met polymorphism (rs4680). Gene determination showed that eighteen were Val(158) homozygotes, forty-four Val/Met(158) heterozygotes, and eighteen were Met(158) homozygotes. All were within the same age range and never documented to have suffered from any neuropsychiatric illness. Bonferroni corrected non-parametric analyses showed that only for the character scale cooperativeness Val(158) homozygotes displayed significant higher scores when compared to Met(158) homozygotes. No significant differences on cooperativeness scores were found between Val(158) and Val/Met(158) carriers or between Met(158) and Val/Met(158) carriers. No differences were observed for the COMT Val(158) Met polymorphism and the other temperament and character scales.
Conclusions: Our findings support the assumption that the Val(158)Met single nucleotide polymorphism (SNP) influences character traits and not only temperament. Our results add to the notion that Val(158) homozygotes are considered to be helpful and empathic and it suggest that these cooperativeness character traits are related to the dopaminergic system.},
  author       = {Baeken, Chris and Claes, Stephan and De Raedt, Rudi},
  issn         = {2162-3279},
  journal      = {BRAIN AND BEHAVIOR},
  keywords     = {DEPRESSION,ASSOCIATION,personality,BEHAVIOR,cooperativeness,SEX,AVERSIVE STIMULI,VAL158MET POLYMORPHISM,PERSONALITY-DISORDERS,O-METHYLTRANSFERASE COMT,PSYCHIATRIC-DISORDERS,Catechol-O-methyltransferase,GENE POLYMORPHISMS},
  language     = {eng},
  number       = {4},
  pages        = {515--520},
  title        = {The influence of COMT Val158Met genotype on the character dimension cooperativeness in healthy females},
  url          = {http://dx.doi.org/10.1002/brb3.233},
  volume       = {4},
  year         = {2014},
}

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