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A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project

(2008) ALLERGY. 63(7). p.865-871
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Abstract
Background: There is evidence that selenium levels are relatively low in Europe and may be falling. Low levels of selenium or low activity of some of the enzymes dependent on selenium have been associated with asthma. Methods: The GA(2)LEN network has organized a multicentre case-control study in Europe to assess the relation of plasma selenium to asthma. The network compared 569 cases in 14 European centres with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 576 controls from the same centres with no diagnosis of asthma and no asthmatic symptoms in the last 12 months. Results: All cases and controls were selected from the same population defined by age and place of residence. Mean plasma selenium concentrations among the controls ranged from 116.3 mu g/l in Palermo to 67.7 mu g/l in Vienna and 56.1 mu g/l among the children in Oslo. Random effects meta-analysis of the results from the centres showed no overall association between asthma and plasma selenium [odds ratio (OR)/10 mu g/l increase in plasma selenium: 1.04; 95% confidence interval (CI): 0.89-1.21] though there was a significantly protective effect in Lodz (OR: 0.48; 95% CI: 0.29-0.78) and a marginally significant adverse effect in Amsterdam (OR: 1.68; 95% CI: 0.98-2.90) and Ghent (OR: 1.35; 95% CI: 1.03-1.77). Conclusion: This study does not support a role for selenium in protection against asthma, but effect modification and confounding cannot be ruled out.
Keywords
SUPPLEMENTATION, SERUM, VITAMIN-E, MILD ASTHMA, TRACE-ELEMENTS, REDUCED SELENIUM, DIETARY ANTIOXIDANTS, INTRINSIC ASTHMA, RANDOMIZED CONTROLLED-TRIAL, GLUTATHIONE-PEROXIDASE ACTIVITY, tobacco smoke, selenium, asthma, environmental, allergy

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MLA
Burney, P, J Potts, J Makowska, et al. “A Case-control Study of the Relation Between Plasma Selenium and Asthma in European Populations: a GA(2)LEN Project.” ALLERGY 63.7 (2008): 865–871. Print.
APA
Burney, P., Potts, J., Makowska, J., Kowalski, M., Phillips, J., Gnatiuc, L., Shaheen, S., et al. (2008). A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project. ALLERGY, 63(7), 865–871.
Chicago author-date
Burney, P, J Potts, J Makowska, M Kowalski, J Phillips, L Gnatiuc, S Shaheen, et al. 2008. “A Case-control Study of the Relation Between Plasma Selenium and Asthma in European Populations: a GA(2)LEN Project.” Allergy 63 (7): 865–871.
Chicago author-date (all authors)
Burney, P, J Potts, J Makowska, M Kowalski, J Phillips, L Gnatiuc, S Shaheen, Guy Joos, Paul Van Cauwenberge, Thibaut Van Zele, K Verbruggen, YANNICK VAN DURME, I Derudder, S Wohrl, J Godnic-Cvar, B Salameh, L Skadhauge, G Thomsen, T Zuberbier, KC Bergmann, L Heinzerling, H Renz, N Al-Fakhri, B Kosche, A Hildenberg, NG Papadopoulos, P Xepapadaki, K Zannikos, M Gjomarkaj, A Bruno, E Pace, S Bonini, M Bresciani, C Gramiccioni, W Fokkens, EJM Weersink, KH Carlsen, E Bakkeheim, C Loureiro, CM Villanueva, C Sanjuas, JP Zock, B Lundback, and C Janson. 2008. “A Case-control Study of the Relation Between Plasma Selenium and Asthma in European Populations: a GA(2)LEN Project.” Allergy 63 (7): 865–871.
Vancouver
1.
Burney P, Potts J, Makowska J, Kowalski M, Phillips J, Gnatiuc L, et al. A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project. ALLERGY. 2008;63(7):865–71.
IEEE
[1]
P. Burney et al., “A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project,” ALLERGY, vol. 63, no. 7, pp. 865–871, 2008.
@article{435895,
  abstract     = {Background: There is evidence that selenium levels are relatively low in Europe and may be falling. Low levels of selenium or low activity of some of the enzymes dependent on selenium have been associated with asthma. 
Methods: The GA(2)LEN network has organized a multicentre case-control study in Europe to assess the relation of plasma selenium to asthma. The network compared 569 cases in 14 European centres with a diagnosis of asthma and reporting asthma symptoms in the last 12 months with 576 controls from the same centres with no diagnosis of asthma and no asthmatic symptoms in the last 12 months. 
Results: All cases and controls were selected from the same population defined by age and place of residence. Mean plasma selenium concentrations among the controls ranged from 116.3 mu g/l in Palermo to 67.7 mu g/l in Vienna and 56.1 mu g/l among the children in Oslo. Random effects meta-analysis of the results from the centres showed no overall association between asthma and plasma selenium [odds ratio (OR)/10 mu g/l increase in plasma selenium: 1.04; 95% confidence interval (CI): 0.89-1.21] though there was a significantly protective effect in Lodz (OR: 0.48; 95% CI: 0.29-0.78) and a marginally significant adverse effect in Amsterdam (OR: 1.68; 95% CI: 0.98-2.90) and Ghent (OR: 1.35; 95% CI: 1.03-1.77). 
Conclusion: This study does not support a role for selenium in protection against asthma, but effect modification and confounding cannot be ruled out.},
  author       = {Burney, P and Potts, J and Makowska, J and Kowalski, M and Phillips, J and Gnatiuc, L and Shaheen, S and Joos, Guy and Van Cauwenberge, Paul and Van Zele, Thibaut and Verbruggen, K and VAN DURME, YANNICK and Derudder, I and Wohrl, S and Godnic-Cvar, J and Salameh, B and Skadhauge, L and Thomsen, G and Zuberbier, T and Bergmann, KC and Heinzerling, L and Renz, H and Al-Fakhri, N and Kosche, B and Hildenberg, A and Papadopoulos, NG and Xepapadaki, P and Zannikos, K and Gjomarkaj, M and Bruno, A and Pace, E and Bonini, S and Bresciani, M and Gramiccioni, C and Fokkens, W and Weersink, EJM and Carlsen, KH and Bakkeheim, E and Loureiro, C and Villanueva, CM and Sanjuas, C and Zock, JP and Lundback, B and Janson, C},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {SUPPLEMENTATION,SERUM,VITAMIN-E,MILD ASTHMA,TRACE-ELEMENTS,REDUCED SELENIUM,DIETARY ANTIOXIDANTS,INTRINSIC ASTHMA,RANDOMIZED CONTROLLED-TRIAL,GLUTATHIONE-PEROXIDASE ACTIVITY,tobacco smoke,selenium,asthma,environmental,allergy},
  language     = {eng},
  number       = {7},
  pages        = {865--871},
  title        = {A case-control study of the relation between plasma selenium and asthma in European populations: a GA(2)LEN project},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2008.01716.x},
  volume       = {63},
  year         = {2008},
}

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