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WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis

Huiyu Tian, Krzysztof Wabnik, Tiantian Niu, Hanbing Li, Qianqian Yu, Stephan Pollmann, Steffen Vanneste UGent, Willy Govaerts UGent, Jakub Rolcik, Markus Geisler, et al. (2014) MOLECULAR PLANT. 7(2). p.277-289
abstract
In plants, the patterning of stem cell-enriched meristems requires a graded auxin response maximum that emerges from the concerted action of polar auxin transport, auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However, mechanisms underlying this auxin response maximum-mediated root stem cell maintenance are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic genes in the quiescent center (QC) of the root and thus provides a robust mechanism for the maintenance of auxin response maximum in the root tip. This WOX5 action is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response repressor. Our combined genetic, cell biology, and computational modeling studies revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback circuit further assures the maintenance of auxin response maximum in the root tip and thereby contributes to the maintenance of distal stem cell (DSC) populations. Our experimental studies and in silico computer simulations both demonstrate that the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient in the root tip and the auxin-mediated root DSC differentiation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FRAMEWORK, GRAVITROPISM, DIFFERENTIATION, RESOLUTION, MECHANISM, DIVISION, PLANT DEVELOPMENT, BIOSYNTHESIS, GRADIENT, TRANSPORT, computer simulation, root patterning, IAA17/AXR3, auxin maximum, WOX5
journal title
MOLECULAR PLANT
Mol. Plant.
volume
7
issue
2
pages
277 - 289
Web of Science type
Article
Web of Science id
000330841400003
JCR category
PLANT SCIENCES
JCR impact factor
6.337 (2014)
JCR rank
9/204 (2014)
JCR quartile
1 (2014)
ISSN
1674-2052
DOI
10.1093/mp/sst118
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to the work
copyright statement
I have transferred the copyright for this publication to the publisher
id
4349989
handle
http://hdl.handle.net/1854/LU-4349989
date created
2014-04-01 15:21:12
date last changed
2016-12-19 15:45:13
@article{4349989,
  abstract     = {In plants, the patterning of stem cell-enriched meristems requires a graded auxin response maximum that emerges from the concerted action of polar auxin transport, auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However, mechanisms underlying this auxin response maximum-mediated root stem cell maintenance are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic genes in the quiescent center (QC) of the root and thus provides a robust mechanism for the maintenance of auxin response maximum in the root tip. This WOX5 action is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response repressor. Our combined genetic, cell biology, and computational modeling studies revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback circuit further assures the maintenance of auxin response maximum in the root tip and thereby contributes to the maintenance of distal stem cell (DSC) populations. Our experimental studies and in silico computer simulations both demonstrate that the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient in the root tip and the auxin-mediated root DSC differentiation.},
  author       = {Tian, Huiyu and Wabnik, Krzysztof and Niu, Tiantian and Li, Hanbing and Yu, Qianqian and Pollmann, Stephan and Vanneste, Steffen and Govaerts, Willy and Rolcik, Jakub and Geisler, Markus and Friml, Jiri and Ding, Zhaojun},
  issn         = {1674-2052},
  journal      = {MOLECULAR PLANT},
  keyword      = {FRAMEWORK,GRAVITROPISM,DIFFERENTIATION,RESOLUTION,MECHANISM,DIVISION,PLANT DEVELOPMENT,BIOSYNTHESIS,GRADIENT,TRANSPORT,computer simulation,root patterning,IAA17/AXR3,auxin maximum,WOX5},
  language     = {eng},
  number       = {2},
  pages        = {277--289},
  title        = {WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis},
  url          = {http://dx.doi.org/10.1093/mp/sst118},
  volume       = {7},
  year         = {2014},
}

Chicago
Tian, Huiyu, Krzysztof Wabnik, Tiantian Niu, Hanbing Li, Qianqian Yu, Stephan Pollmann, Steffen Vanneste, et al. 2014. “WOX5-IAA17 Feedback Circuit-mediated Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis.” Molecular Plant 7 (2): 277–289.
APA
Tian, H., Wabnik, K., Niu, T., Li, H., Yu, Q., Pollmann, S., Vanneste, S., et al. (2014). WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis. MOLECULAR PLANT, 7(2), 277–289.
Vancouver
1.
Tian H, Wabnik K, Niu T, Li H, Yu Q, Pollmann S, et al. WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis. MOLECULAR PLANT. 2014;7(2):277–89.
MLA
Tian, Huiyu, Krzysztof Wabnik, Tiantian Niu, et al. “WOX5-IAA17 Feedback Circuit-mediated Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis.” MOLECULAR PLANT 7.2 (2014): 277–289. Print.