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Natural product biosynthesis in Medicago species

Azra Gholami UGent, Nathan De Geyter UGent, Jacob Pollier UGent, Sofie Goormachtig UGent and Alain Goossens UGent (2014) NATURAL PRODUCT REPORTS. 31(3). p.356-380
abstract
The genus Medicago, a member of the legume (Fabaceae) family, comprises 87 species of flowering plants, including the forage crop M. sativa (alfalfa) and the model legume M. truncatula (barrel medic). Medicago species synthesize a variety of bioactive natural products that are used to engage into symbiotic interactions but also serve to deter pathogens and herbivores. For humans, these bioactive natural products often possess promising pharmaceutical properties. In this review, we focus on the two most interesting and well characterized secondary metabolite classes found in Medicago species, the triterpene saponins and the flavonoids, with a detailed overview of their biosynthesis, regulation, and profiling methods. Furthermore, their biological role within the plant as well as their potential utility for human health or other applications is discussed. Finally, we give an overview of the advances made in metabolic engineering in Medicago species and how the development of novel molecular and omics toolkits can influence a better understanding of this genus in terms of specialized metabolism and chemistry. Throughout, we critically analyze the current bottlenecks and speculate on future directions and opportunities for research and exploitation of Medicago metabolism.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
FUNCTIONAL GENOMICS, ARABIDOPSIS-THALIANA, SATIVA L., GENE-EXPRESSION ATLAS, CINNAMYL ALCOHOL-DEHYDROGENASE, PROANTHOCYANIDIN BIOSYNTHESIS, ANTHOCYANIC VACUOLAR INCLUSIONS, TRUNCATULA CELL-CULTURES, TRITERPENE SAPONIN BIOSYNTHESIS, MYB TRANSCRIPTION FACTOR
journal title
NATURAL PRODUCT REPORTS
Nat. Prod. Rep.
volume
31
issue
3
pages
356 - 380
Web of Science type
Review
Web of Science id
000331175700003
JCR category
CHEMISTRY, MEDICINAL
JCR impact factor
10.107 (2014)
JCR rank
1/59 (2014)
JCR quartile
1 (2014)
ISSN
0265-0568
DOI
10.1039/c3np70104b
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4349743
handle
http://hdl.handle.net/1854/LU-4349743
date created
2014-04-01 14:43:48
date last changed
2016-12-19 15:43:04
@article{4349743,
  abstract     = {The genus Medicago, a member of the legume (Fabaceae) family, comprises 87 species of flowering plants, including the forage crop M. sativa (alfalfa) and the model legume M. truncatula (barrel medic). Medicago species synthesize a variety of bioactive natural products that are used to engage into symbiotic interactions but also serve to deter pathogens and herbivores. For humans, these bioactive natural products often possess promising pharmaceutical properties. In this review, we focus on the two most interesting and well characterized secondary metabolite classes found in Medicago species, the triterpene saponins and the flavonoids, with a detailed overview of their biosynthesis, regulation, and profiling methods. Furthermore, their biological role within the plant as well as their potential utility for human health or other applications is discussed. Finally, we give an overview of the advances made in metabolic engineering in Medicago species and how the development of novel molecular and omics toolkits can influence a better understanding of this genus in terms of specialized metabolism and chemistry. Throughout, we critically analyze the current bottlenecks and speculate on future directions and opportunities for research and exploitation of Medicago metabolism.},
  author       = {Gholami, Azra and De Geyter, Nathan and Pollier, Jacob and Goormachtig, Sofie and Goossens, Alain},
  issn         = {0265-0568},
  journal      = {NATURAL PRODUCT REPORTS},
  keyword      = {FUNCTIONAL GENOMICS,ARABIDOPSIS-THALIANA,SATIVA L.,GENE-EXPRESSION ATLAS,CINNAMYL ALCOHOL-DEHYDROGENASE,PROANTHOCYANIDIN BIOSYNTHESIS,ANTHOCYANIC VACUOLAR INCLUSIONS,TRUNCATULA CELL-CULTURES,TRITERPENE SAPONIN BIOSYNTHESIS,MYB TRANSCRIPTION FACTOR},
  language     = {eng},
  number       = {3},
  pages        = {356--380},
  title        = {Natural product biosynthesis in Medicago species},
  url          = {http://dx.doi.org/10.1039/c3np70104b},
  volume       = {31},
  year         = {2014},
}

Chicago
Gholami, Azra, Nathan De Geyter, Jacob Pollier, Sofie Goormachtig, and Alain Goossens. 2014. “Natural Product Biosynthesis in Medicago Species.” Natural Product Reports 31 (3): 356–380.
APA
Gholami, A., De Geyter, N., Pollier, J., Goormachtig, S., & Goossens, A. (2014). Natural product biosynthesis in Medicago species. NATURAL PRODUCT REPORTS, 31(3), 356–380.
Vancouver
1.
Gholami A, De Geyter N, Pollier J, Goormachtig S, Goossens A. Natural product biosynthesis in Medicago species. NATURAL PRODUCT REPORTS. 2014;31(3):356–80.
MLA
Gholami, Azra, Nathan De Geyter, Jacob Pollier, et al. “Natural Product Biosynthesis in Medicago Species.” NATURAL PRODUCT REPORTS 31.3 (2014): 356–380. Print.