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The function of Fcγ receptors in dendritic cells and macrophages

Martin Guilliams (UGent) , Pierre Bruhns, Yvan Saeys (UGent) , Hamida Hammad (UGent) and Bart Lambrecht (UGent)
(2014) NATURE REVIEWS IMMUNOLOGY. 14(2). p.94-108
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens and to receive feedback control from adaptive immune cells. Although it was long believed that all immunoglobutin Fc receptors are universally expressed by phagocytes, recent findings indicate that only monocyte-derived DCs and macrophages express high levels of activating Fc receptors for IgG (Fc gamma Rs), whereas conventional and plasmacytoid DCs express the inhibitory Fc gamma R. In this Review, we discuss how the uptake, processing and presentation of antigens by DCs and macrophages is influenced by Fc gamma R recognition of innmunoglobulins and immune complexes in the steady state and during inflammation.
Keywords
RII-MEDIATED UPTAKE, DUST MITE ALLERGEN, CD8(+) T-CELLS, ANTIGEN PRESENTATION, IN-VIVO, CROSS-PRESENTATION, CYTOPLASMIC DOMAIN HETEROGENEITY, ANTIBODY-DEPENDENT ENHANCEMENT, DENGUE HEMORRHAGIC-FEVER, IGG IMMUNE-COMPLEXES

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Citation

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Chicago
Guilliams, Martin, Pierre Bruhns, Yvan Saeys, Hamida Hammad, and Bart Lambrecht. 2014. “The Function of Fcγ Receptors in Dendritic Cells and Macrophages.” Nature Reviews Immunology 14 (2): 94–108.
APA
Guilliams, M., Bruhns, P., Saeys, Y., Hammad, H., & Lambrecht, B. (2014). The function of Fcγ receptors in dendritic cells and macrophages. NATURE REVIEWS IMMUNOLOGY, 14(2), 94–108.
Vancouver
1.
Guilliams M, Bruhns P, Saeys Y, Hammad H, Lambrecht B. The function of Fcγ receptors in dendritic cells and macrophages. NATURE REVIEWS IMMUNOLOGY. 2014;14(2):94–108.
MLA
Guilliams, Martin, Pierre Bruhns, Yvan Saeys, et al. “The Function of Fcγ Receptors in Dendritic Cells and Macrophages.” NATURE REVIEWS IMMUNOLOGY 14.2 (2014): 94–108. Print.
@article{4349570,
  abstract     = {Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens and to receive feedback control from adaptive immune cells. Although it was long believed that all immunoglobutin Fc receptors are universally expressed by phagocytes, recent findings indicate that only monocyte-derived DCs and macrophages express high levels of activating Fc receptors for IgG (Fc gamma Rs), whereas conventional and plasmacytoid DCs express the inhibitory Fc gamma R. In this Review, we discuss how the uptake, processing and presentation of antigens by DCs and macrophages is influenced by Fc gamma R recognition of innmunoglobulins and immune complexes in the steady state and during inflammation.},
  author       = {Guilliams, Martin and Bruhns, Pierre and Saeys, Yvan and Hammad, Hamida and Lambrecht, Bart},
  issn         = {1474-1733},
  journal      = {NATURE REVIEWS IMMUNOLOGY},
  keywords     = {RII-MEDIATED UPTAKE,DUST MITE ALLERGEN,CD8(+) T-CELLS,ANTIGEN PRESENTATION,IN-VIVO,CROSS-PRESENTATION,CYTOPLASMIC DOMAIN HETEROGENEITY,ANTIBODY-DEPENDENT ENHANCEMENT,DENGUE HEMORRHAGIC-FEVER,IGG IMMUNE-COMPLEXES},
  language     = {eng},
  number       = {2},
  pages        = {94--108},
  title        = {The function of Fcγ receptors in dendritic cells and macrophages},
  url          = {http://dx.doi.org/10.1038/nri3582},
  volume       = {14},
  year         = {2014},
}

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