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The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

Fabiola Osorio (UGent) , Simon Tavernier (UGent) , Eik Hoffmann (UGent) , Yvan Saeys (UGent) , Liesbet Martens (UGent) , Jessica Vetters (UGent) , Iris Delrue (UGent) , Riet De Rycke (UGent) , Eef Parthoens (UGent) , Philippe Pouliot (UGent) , et al.
(2014) NATURE IMMUNOLOGY. 15(3). p.248-257
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Abstract
The role of the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress in homeostasis of the immune system is incompletely understood. Here we found that dendritic cells (DCs) constitutively activated the UPR sensor IRE-1 alpha and its target, the transcription factor XBP-1, in the absence of ER stress. Loss of XBP-1 in CD11c(+) cells led to defects in phenotype, ER homeostasis and antigen presentation by CD8 alpha(+) conventional DCs, yet the closely related CD11b(+) DCs were unaffected. Whereas the dysregulated ER in XBP-1-deficient DCs resulted from loss of XBP-1 transcriptional activity, the phenotypic and functional defects resulted from regulated IRE-1 alpha-dependent degradation (RIDD) of mRNAs, including those encoding CD18 integrins and components of the major histocompatibility complex (MHC) class I machinery. Thus, a precisely regulated feedback circuit involving IRE-1 alpha and XBP-1 controls the homeostasis of CD8 alpha(+) conventional DCs.
Keywords
ACTIVATION, DIFFERENTIATION, ENDOPLASMIC-RETICULUM STRESS, TRANSCRIPTION FACTOR XBP-1, CROSS-PRESENTATION, MESSENGER-RNAS, STEADY-STATE, ER STRESS, IN-VIVO, IRE1-ALPHA

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MLA
Osorio, Fabiola, et al. “The Unfolded-Protein-Response Sensor IRE-1α Regulates the Function of CD8α+ Dendritic Cells.” NATURE IMMUNOLOGY, vol. 15, no. 3, 2014, pp. 248–57, doi:10.1038/ni.2808.
APA
Osorio, F., Tavernier, S., Hoffmann, E., Saeys, Y., Martens, L., Vetters, J., … Lambrecht, B. (2014). The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. NATURE IMMUNOLOGY, 15(3), 248–257. https://doi.org/10.1038/ni.2808
Chicago author-date
Osorio, Fabiola, Simon Tavernier, Eik Hoffmann, Yvan Saeys, Liesbet Martens, Jessica Vetters, Iris Delrue, et al. 2014. “The Unfolded-Protein-Response Sensor IRE-1α Regulates the Function of CD8α+ Dendritic Cells.” NATURE IMMUNOLOGY 15 (3): 248–57. https://doi.org/10.1038/ni.2808.
Chicago author-date (all authors)
Osorio, Fabiola, Simon Tavernier, Eik Hoffmann, Yvan Saeys, Liesbet Martens, Jessica Vetters, Iris Delrue, Riet De Rycke, Eef Parthoens, Philippe Pouliot, Takao Iwawaki, Sophie Janssens, and Bart Lambrecht. 2014. “The Unfolded-Protein-Response Sensor IRE-1α Regulates the Function of CD8α+ Dendritic Cells.” NATURE IMMUNOLOGY 15 (3): 248–257. doi:10.1038/ni.2808.
Vancouver
1.
Osorio F, Tavernier S, Hoffmann E, Saeys Y, Martens L, Vetters J, et al. The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. NATURE IMMUNOLOGY. 2014;15(3):248–57.
IEEE
[1]
F. Osorio et al., “The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells,” NATURE IMMUNOLOGY, vol. 15, no. 3, pp. 248–257, 2014.
@article{4349536,
  abstract     = {{The role of the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress in homeostasis of the immune system is incompletely understood. Here we found that dendritic cells (DCs) constitutively activated the UPR sensor IRE-1 alpha and its target, the transcription factor XBP-1, in the absence of ER stress. Loss of XBP-1 in CD11c(+) cells led to defects in phenotype, ER homeostasis and antigen presentation by CD8 alpha(+) conventional DCs, yet the closely related CD11b(+) DCs were unaffected. Whereas the dysregulated ER in XBP-1-deficient DCs resulted from loss of XBP-1 transcriptional activity, the phenotypic and functional defects resulted from regulated IRE-1 alpha-dependent degradation (RIDD) of mRNAs, including those encoding CD18 integrins and components of the major histocompatibility complex (MHC) class I machinery. Thus, a precisely regulated feedback circuit involving IRE-1 alpha and XBP-1 controls the homeostasis of CD8 alpha(+) conventional DCs.}},
  author       = {{Osorio, Fabiola and Tavernier, Simon and Hoffmann, Eik and Saeys, Yvan and Martens, Liesbet and Vetters, Jessica and Delrue, Iris and De Rycke, Riet and Parthoens, Eef and Pouliot, Philippe and Iwawaki, Takao and Janssens, Sophie and Lambrecht, Bart}},
  issn         = {{1529-2908}},
  journal      = {{NATURE IMMUNOLOGY}},
  keywords     = {{ACTIVATION,DIFFERENTIATION,ENDOPLASMIC-RETICULUM STRESS,TRANSCRIPTION FACTOR XBP-1,CROSS-PRESENTATION,MESSENGER-RNAS,STEADY-STATE,ER STRESS,IN-VIVO,IRE1-ALPHA}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{248--257}},
  title        = {{The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells}},
  url          = {{http://dx.doi.org/10.1038/ni.2808}},
  volume       = {{15}},
  year         = {{2014}},
}
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