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Beyond E-cadherin: roles of other cadherin superfamily members in cancer

Frans Van Roy (UGent)
(2014) NATURE REVIEWS CANCER. 14(2). p.121-134
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Abstract
Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that the superfamily of transmembrane cadherin proteins encompasses more than 100 members in humans, including other classical cadherins, numerous protocadherins and cadherin-related proteins. Elucidation of their roles in suppression versus initiation or progression of various tumour types is a young but fascinating field of molecular cancer research. These cadherins are very diverse in both structure and function, and their mutual interactions seem to influence biological responses in complex and versatile ways.
Keywords
BREAST-CANCER, P-CADHERIN, N-CADHERIN, GONADOTROPIN-RELEASING-HORMONE, GENOME-WIDE ANALYSIS, PROSTATE-CANCER, GASTRIC-CANCER, VASCULAR ENDOTHELIAL-CADHERIN, CANDIDATE TUMOR-SUPPRESSOR, SQUAMOUS-CELL CARCINOMA

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Citation

Please use this url to cite or link to this publication:

Chicago
Van Roy, Frans. 2014. “Beyond E-cadherin: Roles of Other Cadherin Superfamily Members in Cancer.” Nature Reviews Cancer 14 (2): 121–134.
APA
Van Roy, Frans. (2014). Beyond E-cadherin: roles of other cadherin superfamily members in cancer. NATURE REVIEWS CANCER, 14(2), 121–134.
Vancouver
1.
Van Roy F. Beyond E-cadherin: roles of other cadherin superfamily members in cancer. NATURE REVIEWS CANCER. 2014;14(2):121–34.
MLA
Van Roy, Frans. “Beyond E-cadherin: Roles of Other Cadherin Superfamily Members in Cancer.” NATURE REVIEWS CANCER 14.2 (2014): 121–134. Print.
@article{4349533,
  abstract     = {Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that the superfamily of transmembrane cadherin proteins encompasses more than 100 members in humans, including other classical cadherins, numerous protocadherins and cadherin-related proteins. Elucidation of their roles in suppression versus initiation or progression of various tumour types is a young but fascinating field of molecular cancer research. These cadherins are very diverse in both structure and function, and their mutual interactions seem to influence biological responses in complex and versatile ways.},
  author       = {Van Roy, Frans},
  issn         = {1474-175X},
  journal      = {NATURE REVIEWS CANCER},
  language     = {eng},
  number       = {2},
  pages        = {121--134},
  title        = {Beyond E-cadherin: roles of other cadherin superfamily members in cancer},
  url          = {http://dx.doi.org/10.1038/nrc3647},
  volume       = {14},
  year         = {2014},
}

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