@article{4348227,
  abstract     = {{BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 x 10(-8), HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4 x 10(-8), HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4 x 10(-8), HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2 x 10(-4)). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%-50% compared to 81%-100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers.}},
  articleno    = {{e1003212}},
  author       = {{Couch, Fergus J and Wang, Xianshu and McGuffog, Lesley and Lee, Andrew and Olswold, Curtis and Kuchenbaecker, Karoline B and Soucy, Penny and Fredericksen, Zachary and Barrowdale, Daniel and Dennis, Joe and Gaudet, Mia M and Dicks, Ed and Kosel, Matthew and Healey, Sue and Sinilnikova, Olga M and Lee, Adam and Bacot, François and Vincent, Daniel and Hogervorst, Frans BL and Peock, Susan and Stoppa-Lyonnet, Dominique and Jakubowska, Anna and Radice, Paolo and Schmutzler, Rita Katharina and Domchek, Susan M and Piedmonte, Marion and Singer, Christian F and Friedman, Eitan and Thomassen, Mads and Hansen, Thomas VO and Neuhausen, Susan L and Szabo, Csilla I and Blanco, Ignacio and Greene, Mark H and Karlan, Beth Y and Garber, Judy and Phelan, Catherine M. and Weitzel, Jeffrey N and Montagna, Marco and Olah, Edith and Andrulis, Irene L and Godwin, Andrew K and Yannoukakos, Drakoulis and Goldgar, David E and Caldes, Trinidad and Nevanlinna, Heli and Osorio, Ana and Terry, Mary Beth and Daly, Mary B and van Rensburg, Elizabeth J and Hamann, Ute and Ramus, Susan J and Toland, Amanda Ewart and Caligo, Maria A and Olopade, Olufunmilayo I and Tung, Nadine and Claes, Kathleen and Beattie, Mary S and Southey, Melissa C and Imyanitov, Evgeny N and Tischkowitz, Marc and Janavicius, Ramunas and John, Esther M and Kwong, Ava and Diez, Orland and Balmaña, Judith and Barkardottir, Rosa B and Arun, Banu K and Rennert, Gad and Teo, Soo-Hwang and Ganz, Patricia A and Campbell, Ian and van der Hout, Annemarie H and van Deurzen, Carolien HM and Seynaeve, Caroline and Gómez Garcia, Encarna B and van Leeuwen, Flora E and Meijers-Heijboer, Hanne EJ and Gille, Johannes JP and Ausems, Margreet GEM and Blok, Marinus J and Ligtenberg, Marjolijn JL and Rookus, Matti A and Devilee, Peter and Verhoef, Senno and van Os, Theo AM and Wijnen, Juul T and Frost, Debra and Ellis, Steve and Fineberg, Elena and Platte, Radka and Evans, D Gareth and Izatt, Louise and Eeles, Rosalind A and Adlard, Julian and Eccles, Diana M and Cook, Jackie and Brewer, Carole and Douglas, Fiona and Hodgson, Shirley and Morrison, Patrick J and Side, Lucy E and Donaldson, Alan and Houghton, Catherine and Rogers, Mark T and Dorkins, Huw and Eason, Jacqueline and Gregory, Helen and McCann, Emma and Murray, Alex and Calender, Alain and Hardouin, Agnès and Berthet, Pascaline and Delnatte, Capucine and Nogues, Catherine and Lasset, Christine and Houdayer, Claude and Leroux, Dominique and Rouleau, Etienne and Prieur, Fabienne and Damiola, Francesca and Sobol, Hagay and Coupier, Isabelle and Venat-Bouvet, Laurence and Castera, Laurent and Gauthier-Villars, Marion and Léoné, Mélanie and Pujol, Pascal and Mazoyer, Sylvie and Bignon, Yves-Jean and Złowocka-Perłowska, Elżbieta and Gronwald, Jacek and Lubinski, Jan and Durda, Katarzyna and Jaworska, Katarzyna and Huzarski, Tomasz and Spurdle, Amanda B and Viel, Alessandra and Peissel, Bernard and Bonanni, Bernardo and Melloni, Giulia and Ottini, Laura and Papi, Laura and Varesco, Liliana and Tibiletti, Maria Grazia and Peterlongo, Paolo and Volorio, Sara and Manoukian, Siranoush and Pensotti, Valeria and Arnold, Norbert and Engel, Christoph and Deissler, Helmut and Gadzicki, Dorothea and Gehrig, Andrea and Kast, Karin and Rhiem, Kerstin and Meindl, Alfons and Niederacher, Dieter and Ditsch, Nina and Plendl, Hansjoerg and Preisler-Adams, Sabine and Engert, Stefanie and Sutter, Christian and Varon-Mateeva, Raymonda and Wappenschmidt, Barbara and Weber, Bernhard HF and Arver, Brita and Stenmark-Askmalm, Marie and Loman, Niklas and Rosenquist, Richard and Einbeigi, Zakaria and Nathanson, Katherine L and Rebbeck, Timothy R and Blank, Stephanie V and Cohn, David E and Rodriguez, Gustavo C and Small, Laurie and Friedlander, Michael and Bae-Jump, Victoria L and Fink-Retter, Anneliese and Rappaport, Christine and Gschwantler-Kaulich, Daphne and Pfeiler, Georg and Tea, Muy-Kheng and Lindor, Noralane M and Kaufman, Bella and Paluch, Shani Shimon and Laitman, Yael and Skytte, Anne-Bine and Gerdes, Anne-Marie and Pedersen, Inge Sokilde and Moeller, Sanne Traasdahl and Kruse, Torben A and Jensen, Uffe Birk and Vijai, Joseph and Sarrel, Kara and Robson, Mark and Kauff, Noah and Mulligan, Anna Marie and Glendon, Gord and Ozcelik, Hilmi and Ejlertsen, Bent and Nielsen, Finn C and Jønson, Lars and Andersen, Mette K and Ding, Yuan Chun and Steele, Linda and Foretova, Lenka and Teulé, Alex and Lazaro, Conxi and Brunet, Joan and Pujana, Miquel Angel and Mai, Phuong L and Loud, Jennifer T and Walsh, Christine and Lester, Jenny and Orsulic, Sandra and Narod, Steven A and Herzog, Josef and Sand, Sharon R and Tognazzo, Silvia and Agata, Simona and Vaszko, Tibor and Weaver, Joellen and Stavropoulou, Alexandra V and Buys, Saundra S and Romero, Atocha and de la Hoya, Miguel and Aittomäki, Kristiina and Muranen, Taru A and Duran, Mercedes and Chung, Wendy K and Lasa, Adriana and Dorfling, Cecilia M and Miron, Alexander and Benitez, Javier and Senter, Leigha and Huo, Dezheng and Chan, Salina B and Sokolenko, Anna P and Chiquette, Jocelyne and Tihomirova, Laima and Friebel, Tara M and Agnarsson, Bjarni A and Lu, Karen H and Lejbkowicz, Flavio and James, Paul A and Hall, Per and Dunning, Alison M and Tessier, Daniel and Cunningham, Julie and Slager, Susan L and Wang, Chen and Hart, Steven and Stevens, Kristen and Simard, Jacques and Pastinen, Tomi and Pankratz, Vernon S and Offit, Kenneth and Easton, Douglas F and Chenevix-Trench, Georgia and Antoniou, Antonis C}},
  issn         = {{1553-7404}},
  journal      = {{PLOS GENETICS}},
  keywords     = {{SUSCEPTIBILITY ALLELES,COMMON VARIANTS,GENETIC-VARIANTS,MODIFIERS,INVESTIGATORS,POPULATION,CONSORTIUM,SELECTION,SUBTYPES,ZNF365}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{21}},
  title        = {{Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk}},
  url          = {{http://doi.org/10.1371/journal.pgen.1003212}},
  volume       = {{9}},
  year         = {{2013}},
}

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