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Lessons learned from closed loops in engineering: towards a multivariable approach regulating depth of anaesthesia

Clara-Mihaela Ionescu UGent, Ioana Nascu UGent and Robain De Keyser UGent (2014) JOURNAL OF CLINICAL MONITORING AND COMPUTING. 28(6). p.537-546
abstract
In this paper is presented a brief state of art regarding the multivariable formulation for controlling the depth of anaesthesia by means of two intravenously administrated drugs, i.e. propofol and remifentanil. In a feasibility study of determining a suitable variable to quantify analgesia levels in patients undergoing cardiac surgery, the bispectral index and an electromyogram-based surrogate variable are proposed as the controlled variables. The study is carried on in the context of implementing a multivariable predictive control algorithm. The simulation results show that such a paradigm is feasible, although it does not guarantee perfect knowledge of the analgesia level-in other words, the variable is not validated against typical evaluations of the pain levels (e.g. clinical scores).
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DRUG-INTERACTIONS, BISPECTRAL INDEX, PROPOFOL, REMIFENTANIL, PHARMACODYNAMICS, MODEL, PHARMACOKINETICS, SIMULATION, DELIVERY, SYSTEMS, Anaesthesia, Analgesia, Predictive control, Multivariable control
journal title
JOURNAL OF CLINICAL MONITORING AND COMPUTING
volume
28
issue
6
pages
537 - 546
Web of Science type
Article
Web of Science id
000345768500005
JCR category
ANESTHESIOLOGY
JCR impact factor
1.985 (2014)
JCR rank
16/30 (2014)
JCR quartile
3 (2014)
ISSN
1387-1307
DOI
10.1007/s10877-013-9535-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4343538
handle
http://hdl.handle.net/1854/LU-4343538
date created
2014-03-25 10:15:32
date last changed
2016-12-19 15:38:48
@article{4343538,
  abstract     = {In this paper is presented a brief state of art regarding the multivariable formulation for controlling the depth of anaesthesia by means of two intravenously administrated drugs, i.e. propofol and remifentanil. In a feasibility study of determining a suitable variable to quantify analgesia levels in patients undergoing cardiac surgery, the bispectral index and an electromyogram-based surrogate variable are proposed as the controlled variables. The study is carried on in the context of implementing a multivariable predictive control algorithm. The simulation results show that such a paradigm is feasible, although it does not guarantee perfect knowledge of the analgesia level-in other words, the variable is not validated against typical evaluations of the pain levels (e.g. clinical scores).},
  author       = {Ionescu, Clara-Mihaela and Nascu, Ioana and De Keyser, Robain},
  issn         = {1387-1307},
  journal      = {JOURNAL OF CLINICAL MONITORING AND COMPUTING},
  keyword      = {DRUG-INTERACTIONS,BISPECTRAL INDEX,PROPOFOL,REMIFENTANIL,PHARMACODYNAMICS,MODEL,PHARMACOKINETICS,SIMULATION,DELIVERY,SYSTEMS,Anaesthesia,Analgesia,Predictive control,Multivariable control},
  language     = {eng},
  number       = {6},
  pages        = {537--546},
  title        = {Lessons learned from closed loops in engineering: towards a multivariable approach regulating depth of anaesthesia},
  url          = {http://dx.doi.org/10.1007/s10877-013-9535-5},
  volume       = {28},
  year         = {2014},
}

Chicago
Ionescu, Clara-Mihaela, Ioana Nascu, and Robain De Keyser. 2014. “Lessons Learned from Closed Loops in Engineering: Towards a Multivariable Approach Regulating Depth of Anaesthesia.” Journal of Clinical Monitoring and Computing 28 (6): 537–546.
APA
Ionescu, C.-M., Nascu, I., & De Keyser, R. (2014). Lessons learned from closed loops in engineering: towards a multivariable approach regulating depth of anaesthesia. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 28(6), 537–546.
Vancouver
1.
Ionescu C-M, Nascu I, De Keyser R. Lessons learned from closed loops in engineering: towards a multivariable approach regulating depth of anaesthesia. JOURNAL OF CLINICAL MONITORING AND COMPUTING. 2014;28(6):537–46.
MLA
Ionescu, Clara-Mihaela, Ioana Nascu, and Robain De Keyser. “Lessons Learned from Closed Loops in Engineering: Towards a Multivariable Approach Regulating Depth of Anaesthesia.” JOURNAL OF CLINICAL MONITORING AND COMPUTING 28.6 (2014): 537–546. Print.