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Innate immune cells in asthma

Julie Deckers UGent, Filipe Branco Madeira UGent and Hamida Hammad UGent (2013) TRENDS IN IMMUNOLOGY. 34(1). p.540-547
abstract
Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
HOUSE-DUST MITE, ANTIGEN-PRESENTING CELLS, TRANSCRIPTION FACTOR GATA3, INDUCED AIRWAY INFLAMMATION, ALLERGIC LUNG INFLAMMATION, HELPER TYPE-2 RESPONSE, HUMAN MAST-CELLS, LYMPHOID-CELLS, DENDRITIC CELLS, IN-VIVO
journal title
TRENDS IN IMMUNOLOGY
Trends Immunol.
volume
34
issue
1
pages
540 - 547
Web of Science type
Review
Web of Science id
000327282700003
JCR category
IMMUNOLOGY
JCR impact factor
12.031 (2013)
JCR rank
7/144 (2013)
JCR quartile
1 (2013)
ISSN
1471-4906
DOI
10.1016/j.it.2013.08.004
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4339804
handle
http://hdl.handle.net/1854/LU-4339804
date created
2014-03-19 18:28:32
date last changed
2016-12-19 15:37:58
@article{4339804,
  abstract     = {Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity.},
  author       = {Deckers, Julie and Branco Madeira, Filipe and Hammad, Hamida},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  keyword      = {HOUSE-DUST MITE,ANTIGEN-PRESENTING CELLS,TRANSCRIPTION FACTOR GATA3,INDUCED AIRWAY INFLAMMATION,ALLERGIC LUNG INFLAMMATION,HELPER TYPE-2 RESPONSE,HUMAN MAST-CELLS,LYMPHOID-CELLS,DENDRITIC CELLS,IN-VIVO},
  language     = {eng},
  number       = {1},
  pages        = {540--547},
  title        = {Innate immune cells in asthma},
  url          = {http://dx.doi.org/10.1016/j.it.2013.08.004},
  volume       = {34},
  year         = {2013},
}

Chicago
Deckers, Julie, Filipe Branco Madeira, and Hamida Hammad. 2013. “Innate Immune Cells in Asthma.” Trends in Immunology 34 (1): 540–547.
APA
Deckers, J., Branco Madeira, F., & Hammad, H. (2013). Innate immune cells in asthma. TRENDS IN IMMUNOLOGY, 34(1), 540–547.
Vancouver
1.
Deckers J, Branco Madeira F, Hammad H. Innate immune cells in asthma. TRENDS IN IMMUNOLOGY. 2013;34(1):540–7.
MLA
Deckers, Julie, Filipe Branco Madeira, and Hamida Hammad. “Innate Immune Cells in Asthma.” TRENDS IN IMMUNOLOGY 34.1 (2013): 540–547. Print.