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Selective serotonin reuptake inhibitors as a novel class of immunosuppressants

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Abstract
In the past decades, selective serotonin reuptake inhibitors (SSRIs) have been shown to exert several immunological effects, such as reduced lymphocyte proliferation, alteration of cytokine secretion and induction of apoptosis. Based on these effects, SSRIs were proposed as drugs for the treatment of autoimmune pathologies and graft-versus-host disease. This review summarizes preclinical and clinical evidence supporting a role for SSRIs in autoimmune diseases and graft-versus-host disease, and discusses what is known about the mechanism underlying these effects.
Keywords
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, Autoimmune diseases, Graft-versus-host disease, Lymphocytes, Immunosuppression, Selective serotonin reuptake inhibitors, PERIPHERAL-BLOOD LYMPHOCYTES, BURKITT-LYMPHOMA CELLS, VERSUS-HOST-DISEASE, FUNCTION IN-VITRO, RHEUMATOID-ARTHRITIS, INTERFERON-GAMMA, T-CELLS, ANTIDEPRESSANTS IMIPRAMINE, MULTIPLE-SCLEROSIS

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Chicago
Gobin, Veerle, Katleen Van Steendam, Damiaan Denys, and Dieter Deforce. 2014. “Selective Serotonin Reuptake Inhibitors as a Novel Class of Immunosuppressants.” International Immunopharmacology 20 (1): 148–156.
APA
Gobin, V., Van Steendam, K., Denys, D., & Deforce, D. (2014). Selective serotonin reuptake inhibitors as a novel class of immunosuppressants. INTERNATIONAL IMMUNOPHARMACOLOGY, 20(1), 148–156.
Vancouver
1.
Gobin V, Van Steendam K, Denys D, Deforce D. Selective serotonin reuptake inhibitors as a novel class of immunosuppressants. INTERNATIONAL IMMUNOPHARMACOLOGY. 2014;20(1):148–56.
MLA
Gobin, Veerle, Katleen Van Steendam, Damiaan Denys, et al. “Selective Serotonin Reuptake Inhibitors as a Novel Class of Immunosuppressants.” INTERNATIONAL IMMUNOPHARMACOLOGY 20.1 (2014): 148–156. Print.
@article{4332233,
  abstract     = {In the past decades, selective serotonin reuptake inhibitors (SSRIs) have been shown to exert several immunological effects, such as reduced lymphocyte proliferation, alteration of cytokine secretion and induction of apoptosis. Based on these effects, SSRIs were proposed as drugs for the treatment of autoimmune pathologies and graft-versus-host disease. This review summarizes preclinical and clinical evidence supporting a role for SSRIs in autoimmune diseases and graft-versus-host disease, and discusses what is known about the mechanism underlying these effects.},
  author       = {Gobin, Veerle and Van Steendam, Katleen and Denys, Damiaan and Deforce, Dieter},
  issn         = {1567-5769},
  journal      = {INTERNATIONAL IMMUNOPHARMACOLOGY},
  keyword      = {EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS,Autoimmune diseases,Graft-versus-host disease,Lymphocytes,Immunosuppression,Selective serotonin reuptake inhibitors,PERIPHERAL-BLOOD LYMPHOCYTES,BURKITT-LYMPHOMA CELLS,VERSUS-HOST-DISEASE,FUNCTION IN-VITRO,RHEUMATOID-ARTHRITIS,INTERFERON-GAMMA,T-CELLS,ANTIDEPRESSANTS IMIPRAMINE,MULTIPLE-SCLEROSIS},
  language     = {eng},
  number       = {1},
  pages        = {148--156},
  title        = {Selective serotonin reuptake inhibitors as a novel class of immunosuppressants},
  url          = {http://dx.doi.org/10.1016/j.intimp.2014.02.030},
  volume       = {20},
  year         = {2014},
}

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