Ghent University Academic Bibliography

Advanced

A protein domain-based interactome network for C. elegans early embryogenesis

Mike Boxem, Zoltan Maliga, Niels Klitgord, Na Li, Irma Lemmens UGent, Miyeko Mana, Lorenzo de Lichtervelde, Joram D Mul, Diederik van de Peut and Maxime Devos, et al. (2008) CELL. 134(3). p.534-545
abstract
Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome'' networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in amore complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INTERACTION MAP, GENOME, 2-HYBRID SCREENS, CENTROSOME MATURATION, SACCHAROMYCES-CEREVISIAE, NUCLEAR-PORE COMPLEX, CAENORHABDITIS-ELEGANS, IDENTIFICATION, RESOURCE, SCALE
journal title
CELL
Cell
volume
134
issue
3
pages
534 - 545
Web of Science type
Article
Web of Science id
000258665500025
JCR category
CELL BIOLOGY
JCR impact factor
31.253 (2008)
JCR rank
3/157 (2008)
JCR quartile
1 (2008)
ISSN
0092-8674
DOI
10.1016/j.cell.2008.07.009
language
English
UGent publication?
yes
classification
A1
additional info
correction published in Cell (2012) 151(7), 1633 ; DOI 10.1016/j.cell.2012.11.042
copyright statement
I have transferred the copyright for this publication to the publisher
id
433014
handle
http://hdl.handle.net/1854/LU-433014
date created
2008-10-27 17:09:00
date last changed
2013-03-11 15:29:45
@article{433014,
  abstract     = {Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or {\textacutedbl}interactome'' networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in amore complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms.},
  author       = {Boxem, Mike and Maliga, Zoltan and Klitgord, Niels and Li, Na and Lemmens, Irma and Mana, Miyeko and de Lichtervelde, Lorenzo and Mul, Joram D and van de Peut, Diederik and Devos, Maxime and Simonis, Nicolas and Yildirim, Muhammed A and Cokol, Murat and Kao, Huey-Ling and De Smet, Anne-Sophie and Wang, Haidong and Schlaitz, Anne-Lore and Hao, Tong and Milstein, Stuart and Fan, Changyu and Tipsword, Mike and Drew, Kevin and Galli, Matilde and Rhrissorrakrai, Kahn and Drechsel, David and Koller, Daphne and Roth, Frederick P and Iakoucheva, Lilia M and Dunker, A Keith and Bonneau, Richard and Gunsalus, Kristin C and Hill, David E and Piano, Fabio and Tavernier, Jan and van den Heuvel, Sander and Hyman, Anthony A and Vidal, Marc},
  issn         = {0092-8674},
  journal      = {CELL},
  keyword      = {INTERACTION MAP,GENOME,2-HYBRID SCREENS,CENTROSOME MATURATION,SACCHAROMYCES-CEREVISIAE,NUCLEAR-PORE COMPLEX,CAENORHABDITIS-ELEGANS,IDENTIFICATION,RESOURCE,SCALE},
  language     = {eng},
  number       = {3},
  pages        = {534--545},
  title        = {A protein domain-based interactome network for C. elegans early embryogenesis},
  url          = {http://dx.doi.org/10.1016/j.cell.2008.07.009},
  volume       = {134},
  year         = {2008},
}

Chicago
Boxem, Mike, Zoltan Maliga, Niels Klitgord, Na Li, Irma Lemmens, Miyeko Mana, Lorenzo de Lichtervelde, et al. 2008. “A Protein Domain-based Interactome Network for C. Elegans Early Embryogenesis.” Cell 134 (3): 534–545.
APA
Boxem, M., Maliga, Z., Klitgord, N., Li, N., Lemmens, I., Mana, M., de Lichtervelde, L., et al. (2008). A protein domain-based interactome network for C. elegans early embryogenesis. CELL, 134(3), 534–545.
Vancouver
1.
Boxem M, Maliga Z, Klitgord N, Li N, Lemmens I, Mana M, et al. A protein domain-based interactome network for C. elegans early embryogenesis. CELL. 2008;134(3):534–45.
MLA
Boxem, Mike, Zoltan Maliga, Niels Klitgord, et al. “A Protein Domain-based Interactome Network for C. Elegans Early Embryogenesis.” CELL 134.3 (2008): 534–545. Print.