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Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro

(2014) MATERIALS. 7(2). p.1342-1359
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Abstract
Due to the weak regeneration potential of cartilage, there is a high clinical incidence of articular joint disease, leading to a strong demand for cartilaginous tissue surrogates. The aim of this study was to evaluate a gelatin-based hydrogel for its suitability to support chondrogenic differentiation of human mesenchymal stem cells. Gelatin-based hydrogels are biodegradable, show high biocompatibility, and offer possibilities to introduce functional groups and/or ligands. In order to prove their chondrogenesis-supporting potential, a hydrogel film was developed and compared with standard cell culture polystyrene regarding the differentiation behavior of human mesenchymal stem cells. Cellular basis for this study were human adipose tissue-derived mesenchymal stem cells, which exhibit differentiation potential along the adipogenic, osteogenic and chondrogenic lineage. The results obtained show a promotive effect of gelatin-based hydrogels on chondrogenic differentiation of mesenchymal stem cells in vitro and therefore encourage subsequent in vivo studies.
Keywords
chondrogenic differentiation, tissue engineering, gelatin-based hydrogels, adipose tissue-derived mesenchymal stem cells (adMSC), GROWTH-FACTOR GENE, INTERNATIONAL-SOCIETY, STROMAL CELLS, ALCIAN BLUE, BONE, CARTILAGE, HYPOXIA, OSTEOGENESIS, REGENERATION, CHONDROCYTES

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MLA
Salamon, Achim, Sandra Van Vlierberghe, Ine Van Nieuwenhove, et al. “Gelatin-based Hydrogels Promote Chondrogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells in Vitro.” MATERIALS 7.2 (2014): 1342–1359. Print.
APA
Salamon, A., Van Vlierberghe, S., Van Nieuwenhove, I., Baudisch, F., Graulus, G.-J., Benecke, V., Alberti, K., et al. (2014). Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro. MATERIALS, 7(2), 1342–1359.
Chicago author-date
Salamon, Achim, Sandra Van Vlierberghe, Ine Van Nieuwenhove, Frank Baudisch, Geert-Jan Graulus, Verena Benecke, Kristin Alberti, et al. 2014. “Gelatin-based Hydrogels Promote Chondrogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells in Vitro.” Materials 7 (2): 1342–1359.
Chicago author-date (all authors)
Salamon, Achim, Sandra Van Vlierberghe, Ine Van Nieuwenhove, Frank Baudisch, Geert-Jan Graulus, Verena Benecke, Kristin Alberti, Hans-Georg Neumann, Joachim Rychly, José Martins, Peter Dubruel, and Kirsten Peters. 2014. “Gelatin-based Hydrogels Promote Chondrogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells in Vitro.” Materials 7 (2): 1342–1359.
Vancouver
1.
Salamon A, Van Vlierberghe S, Van Nieuwenhove I, Baudisch F, Graulus G-J, Benecke V, et al. Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro. MATERIALS. 2014;7(2):1342–59.
IEEE
[1]
A. Salamon et al., “Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro,” MATERIALS, vol. 7, no. 2, pp. 1342–1359, 2014.
@article{4328537,
  abstract     = {Due to the weak regeneration potential of cartilage, there is a high clinical incidence of articular joint disease, leading to a strong demand for cartilaginous tissue surrogates. The aim of this study was to evaluate a gelatin-based hydrogel for its suitability to support chondrogenic differentiation of human mesenchymal stem cells. Gelatin-based hydrogels are biodegradable, show high biocompatibility, and offer possibilities to introduce functional groups and/or ligands. In order to prove their chondrogenesis-supporting potential, a hydrogel film was developed and compared with standard cell culture polystyrene regarding the differentiation behavior of human mesenchymal stem cells. Cellular basis for this study were human adipose tissue-derived mesenchymal stem cells, which exhibit differentiation potential along the adipogenic, osteogenic and chondrogenic lineage. The results obtained show a promotive effect of gelatin-based hydrogels on chondrogenic differentiation of mesenchymal stem cells in vitro and therefore encourage subsequent in vivo studies.},
  author       = {Salamon, Achim and Van Vlierberghe, Sandra and Van Nieuwenhove, Ine and Baudisch, Frank and Graulus, Geert-Jan and Benecke, Verena and Alberti, Kristin and Neumann, Hans-Georg and Rychly, Joachim and Martins, José and Dubruel, Peter and Peters, Kirsten},
  issn         = {1996-1944},
  journal      = {MATERIALS},
  keywords     = {chondrogenic differentiation,tissue engineering,gelatin-based hydrogels,adipose tissue-derived mesenchymal stem cells (adMSC),GROWTH-FACTOR GENE,INTERNATIONAL-SOCIETY,STROMAL CELLS,ALCIAN BLUE,BONE,CARTILAGE,HYPOXIA,OSTEOGENESIS,REGENERATION,CHONDROCYTES},
  language     = {eng},
  number       = {2},
  pages        = {1342--1359},
  title        = {Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro},
  url          = {http://dx.doi.org/10.3390/ma7021342},
  volume       = {7},
  year         = {2014},
}

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