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Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer

(2013) BRITISH JOURNAL OF CANCER. 109(1). p.114-120
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we examined a possible prognostic value of FHL2 in CRC. Immunohistochemistry for FHL2 was performed on 296 CRCs without distant metastases at the time of surgery. Staining in the epithelial compartment was quantitatively evaluated using image analysis, Background: Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC)., Methods: Here, and results were related to clinical variables. Antibody specificity was tested using small-interfering RNA transfection in hTERT-immortalised myofibroblasts., Results: Varying degrees of cytoplasmic FHL2 expression by neoplastic epithelial cells were detectable in all cases. Higher FHL2 expression in the epithelial compartment was an independent adverse prognostic factor. Multivariate Cox analysis shows that expression in the tumour invasion front (P<0.001) as well as in the centre of the tumour (P<0.001) was associated with metachronous metastases independently of the clinicopathological variables, suggesting that FHL2 is an independent adverse prognostic indicator for CRC., expression in the tumour invasion front was also associated with overall survival independently of the clinicopathological variables (P<0.01)., Conclusion: Higher FHL2 expression is involved in CRC progression and correlates with the development of metachronous metastases and overall survival

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MLA
Verset, L, Joke Tommelein, X Moles Lopez, et al. “Epithelial Expression of FHL2 Is Negatively Associated with Metastasis-free and Overall Survival in Colorectal Cancer.” BRITISH JOURNAL OF CANCER 109.1 (2013): 114–120. Print.
APA
Verset, L, Tommelein, J., Lopez, X. M., Decaestecker, C., Mareel, M., Bracke, M., Salmon, I., et al. (2013). Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. BRITISH JOURNAL OF CANCER, 109(1), 114–120.
Chicago author-date
Verset, L, Joke Tommelein, X Moles Lopez, Carolien Decaestecker, Marcus Mareel, Marc Bracke, Ilse Salmon, Olivier De Wever, and P Demetter. 2013. “Epithelial Expression of FHL2 Is Negatively Associated with Metastasis-free and Overall Survival in Colorectal Cancer.” British Journal of Cancer 109 (1): 114–120.
Chicago author-date (all authors)
Verset, L, Joke Tommelein, X Moles Lopez, Carolien Decaestecker, Marcus Mareel, Marc Bracke, Ilse Salmon, Olivier De Wever, and P Demetter. 2013. “Epithelial Expression of FHL2 Is Negatively Associated with Metastasis-free and Overall Survival in Colorectal Cancer.” British Journal of Cancer 109 (1): 114–120.
Vancouver
1.
Verset L, Tommelein J, Lopez XM, Decaestecker C, Mareel M, Bracke M, et al. Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. BRITISH JOURNAL OF CANCER. 2013;109(1):114–20.
IEEE
[1]
L. Verset et al., “Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer,” BRITISH JOURNAL OF CANCER, vol. 109, no. 1, pp. 114–120, 2013.
@article{4328478,
  author       = {Verset, L and Tommelein, Joke and Lopez, X Moles and Decaestecker, Carolien and Mareel, Marcus and Bracke, Marc and Salmon, Ilse and De Wever, Olivier and Demetter, P},
  issn         = {0007-0920},
  journal      = {BRITISH JOURNAL OF CANCER},
  keywords     = {we examined a possible prognostic value of FHL2 in CRC. Immunohistochemistry for FHL2 was performed on 296 CRCs without distant metastases at the time of surgery. Staining in the epithelial compartment was quantitatively evaluated using image analysis,Background: Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC).,Methods: Here,and results were related to clinical variables. Antibody specificity was tested using small-interfering RNA transfection in hTERT-immortalised myofibroblasts.,Results: Varying degrees of cytoplasmic FHL2 expression by neoplastic epithelial cells were detectable in all cases. Higher FHL2 expression in the epithelial compartment was an independent adverse prognostic factor. Multivariate Cox analysis shows that expression in the tumour invasion front (P<0.001) as well as in the centre of the tumour (P<0.001) was associated with metachronous metastases independently of the clinicopathological variables,suggesting that FHL2 is an independent adverse prognostic indicator for CRC.,expression in the tumour invasion front was also associated with overall survival independently of the clinicopathological variables (P<0.01).,Conclusion: Higher FHL2 expression is involved in CRC progression and correlates with the development of metachronous metastases and overall survival},
  language     = {eng},
  number       = {1},
  pages        = {114--120},
  title        = {Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer},
  url          = {http://dx.doi.org/10.1038/bjc.2013.290},
  volume       = {109},
  year         = {2013},
}

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