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Ultrasound submucosal inferior nasal turbinate reduction technique : histological study of wound healing in a sheep model

Christina Nousia, Haralampos Gouverisi, Alexandra Giatromanolaki, Petros Ypsilantis, Michael Katotomichelakisi, Jean-Baptiste Watelet UGent, Konstantinos Simopoulos and Vassilios Danielides (2010) RHINOLOGY. 48(2). p.169-173
abstract
Aim of study: To describe histological changes after application of an ultrasound tissue reduction (UTR) technique in a newly introduced sheep model to study inferior nasal turbinate mucosal wound healing. Materials and Methods: An experimental study in a sheep model. Stromal fibrosis, submucosal interstitial space volume (ISV) mucosal epithelial cell necrosis, mucosal inflammation and blood vessels' engorgement in inferior turbinate samples were assessed after application of UTR using hematoxylin/eosin staining in 12 turbinate samples after different time points. Histological grading was performed using a 4-point scale Results: After one week, extensive development of fibrosis (p = 0.006) and significant reduced stromal ISV (p < 0.001) compared to controls were observed. The degree of fibrosis and the stromal ISV remained constant during the 8-week period. The extensive epithelial cell necrosis observed at week 1, diminished later, so that at 8 weeks no significant difference with controls in the necrosis extent was noted. Significant reduction of engorgement of blood vessels in the submucosal layer was noted after 8 weeks (p = 0.008, compared with baseline). Mucosal inflammation, while pronounced at week 1 (p = 0.005, compared with baseline), was normalized at week 8. Conclusion: Due to the rapid induction of extensive fibrosis, to the limited inflammation reaction, to the moderate degree of epithelial necrosis, to the reduction of subepithelial ISV and the persistence of these features till week 8 at least, UTR emerges as an effective minimally invasive technique for inferior nasal turbinate volume reduction.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SINUS SURGERY, wound healing, histology, surgery, nasal mucosa, ultrasound, inferior turbinate
journal title
RHINOLOGY
Rhinology
volume
48
issue
2
pages
169 - 173
Web of Science type
Article
Web of Science id
000291894400009
JCR category
OTORHINOLARYNGOLOGY
JCR impact factor
0.803 (2010)
JCR rank
26/41 (2010)
JCR quartile
3 (2010)
ISSN
0300-0729
DOI
10.4193/Rhin09.143
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
4326460
handle
http://hdl.handle.net/1854/LU-4326460
date created
2014-03-07 14:37:30
date last changed
2018-07-02 09:29:03
@article{4326460,
  abstract     = {Aim of study: To describe histological changes after application of an ultrasound tissue reduction (UTR) technique in a newly introduced sheep model to study inferior nasal turbinate mucosal wound healing.
Materials and Methods: An experimental study in a sheep model. Stromal fibrosis, submucosal interstitial space volume (ISV) mucosal epithelial cell necrosis, mucosal inflammation and blood vessels' engorgement in inferior turbinate samples were assessed after application of UTR using hematoxylin/eosin staining in 12 turbinate samples after different time points. Histological grading was performed using a 4-point scale
Results: After one week, extensive development of fibrosis (p = 0.006) and significant reduced stromal ISV (p {\textlangle} 0.001) compared to controls were observed. The degree of fibrosis and the stromal ISV remained constant during the 8-week period. The extensive epithelial cell necrosis observed at week 1, diminished later, so that at 8 weeks no significant difference with controls in the necrosis extent was noted. Significant reduction of engorgement of blood vessels in the submucosal layer was noted after 8 weeks (p = 0.008, compared with baseline). Mucosal inflammation, while pronounced at week 1 (p = 0.005, compared with baseline), was normalized at week 8.
Conclusion: Due to the rapid induction of extensive fibrosis, to the limited inflammation reaction, to the moderate degree of epithelial necrosis, to the reduction of subepithelial ISV and the persistence of these features till week 8 at least, UTR emerges as an effective minimally invasive technique for inferior nasal turbinate volume reduction.},
  author       = {Nousia, Christina and Gouverisi, Haralampos and Giatromanolaki, Alexandra and Ypsilantis, Petros and Katotomichelakisi, Michael and Watelet, Jean-Baptiste and Simopoulos, Konstantinos and Danielides, Vassilios},
  issn         = {0300-0729},
  journal      = {RHINOLOGY},
  keyword      = {SINUS SURGERY,wound healing,histology,surgery,nasal mucosa,ultrasound,inferior turbinate},
  language     = {eng},
  number       = {2},
  pages        = {169--173},
  title        = {Ultrasound submucosal inferior nasal turbinate reduction technique : histological study of wound healing in a sheep model},
  url          = {http://dx.doi.org/10.4193/Rhin09.143},
  volume       = {48},
  year         = {2010},
}

Chicago
Nousia, Christina, Haralampos Gouverisi, Alexandra Giatromanolaki, Petros Ypsilantis, Michael Katotomichelakisi, Jean-Baptiste Watelet, Konstantinos Simopoulos, and Vassilios Danielides. 2010. “Ultrasound Submucosal Inferior Nasal Turbinate Reduction Technique : Histological Study of Wound Healing in a Sheep Model.” Rhinology 48 (2): 169–173.
APA
Nousia, Christina, Gouverisi, H., Giatromanolaki, A., Ypsilantis, P., Katotomichelakisi, M., Watelet, J.-B., Simopoulos, K., et al. (2010). Ultrasound submucosal inferior nasal turbinate reduction technique : histological study of wound healing in a sheep model. RHINOLOGY, 48(2), 169–173.
Vancouver
1.
Nousia C, Gouverisi H, Giatromanolaki A, Ypsilantis P, Katotomichelakisi M, Watelet J-B, et al. Ultrasound submucosal inferior nasal turbinate reduction technique : histological study of wound healing in a sheep model. RHINOLOGY. 2010;48(2):169–73.
MLA
Nousia, Christina, Haralampos Gouverisi, Alexandra Giatromanolaki, et al. “Ultrasound Submucosal Inferior Nasal Turbinate Reduction Technique : Histological Study of Wound Healing in a Sheep Model.” RHINOLOGY 48.2 (2010): 169–173. Print.