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A nonlinear mixed effects IVIVC model for multi-release drug delivery systems

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Abstract
The purpose of this analysis was the development of an IVIVC model, which involves a convolution step as described by O'Hara et al. and to describe a dual-release system: a controlled release formulation, which contains an initial immediate release element. Four formulations of Galantamine((R)) were used to test this modelling technique and a level A IVIVC, which meets the FDA criteria for internal and external validation, was successfully developed.
Keywords
PLACEBO-CONTROLLED TRIAL, GALANTAMINE, GALANTHAMINE, controlled release, population pharmacokinetics, AD, in vitro/in vivo correlation, dissolution

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MLA
Rossenu, S, C Gaynor, An Vermeulen, et al. “A Nonlinear Mixed Effects IVIVC Model for Multi-release Drug Delivery Systems.” JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 35.4 (2008): 423–441. Print.
APA
Rossenu, S, Gaynor, C., Vermeulen, A., Cleton, A., & Dunne, A. (2008). A nonlinear mixed effects IVIVC model for multi-release drug delivery systems. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 35(4), 423–441.
Chicago author-date
Rossenu, S, C Gaynor, An Vermeulen, Adriaan Cleton, and Adrian Dunne. 2008. “A Nonlinear Mixed Effects IVIVC Model for Multi-release Drug Delivery Systems.” Journal of Pharmacokinetics and Pharmacodynamics 35 (4): 423–441.
Chicago author-date (all authors)
Rossenu, S, C Gaynor, An Vermeulen, Adriaan Cleton, and Adrian Dunne. 2008. “A Nonlinear Mixed Effects IVIVC Model for Multi-release Drug Delivery Systems.” Journal of Pharmacokinetics and Pharmacodynamics 35 (4): 423–441.
Vancouver
1.
Rossenu S, Gaynor C, Vermeulen A, Cleton A, Dunne A. A nonlinear mixed effects IVIVC model for multi-release drug delivery systems. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. 2008;35(4):423–41.
IEEE
[1]
S. Rossenu, C. Gaynor, A. Vermeulen, A. Cleton, and A. Dunne, “A nonlinear mixed effects IVIVC model for multi-release drug delivery systems,” JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, vol. 35, no. 4, pp. 423–441, 2008.
@article{4325520,
  abstract     = {The purpose of this analysis was the development of an IVIVC model, which involves a convolution step as described by O'Hara et al. and to describe a dual-release system: a controlled release formulation, which contains an initial immediate release element. Four formulations of Galantamine((R)) were used to test this modelling technique and a level A IVIVC, which meets the FDA criteria for internal and external validation, was successfully developed.},
  author       = {Rossenu, S and Gaynor, C and Vermeulen, An and Cleton, Adriaan and Dunne, Adrian},
  issn         = {1567-567X},
  journal      = {JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS},
  keywords     = {PLACEBO-CONTROLLED TRIAL,GALANTAMINE,GALANTHAMINE,controlled release,population pharmacokinetics,AD,in vitro/in vivo correlation,dissolution},
  language     = {eng},
  number       = {4},
  pages        = {423--441},
  title        = {A nonlinear mixed effects IVIVC model for multi-release drug delivery systems},
  url          = {http://dx.doi.org/10.1007/s10928-008-9095-3},
  volume       = {35},
  year         = {2008},
}

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