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Abstract
Pharmacokinetics are typically dependent on a variety of physiological variables (e.g., age, ethnicity, or pregnancy) or pathological conditions (e.g., renal and hepatic insufficiency, cardiac dysfunction, obesity, etc.). The influence of some of these conditions has not always been thoroughly assessed in the clinical studies of antiallergic drugs. However, the knowledge of the physiological grounds of the pharmacokinetics can provide some insight for predicting the potential alterations and guiding the initial prescription strategies. It is important to recognize that both pharmacokinetic and pharmacodynamic differences between populations should be considered. The available information on drugs used for the therapy of allergic diseases is reviewed in this chapter.
Keywords
pharmacokinetics, pharmacodynamics, Antiallergic drugs, renal impairment, hepatic impairment, demographic covariates, pregnancy, milk transfer, LIVER ALCOHOL-DEHYDROGENASE, CONGESTIVE HEART-FAILURE, CHRONIC-RENAL-FAILURE, FUROATE NASAL SPRAY, HEALTHY JAPANESE VOLUNTEERS, PERENNIAL ALLERGIC RHINITIS, HEPATIC DRUG-METABOLISM, HISTAMINE-INDUCED WHEAL, CLINICAL-PHARMACOLOGY, HUMAN PLACENTA

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Citation

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Chicago
Poggesi, Italo, Margherita Strolin Benedetti, Rhys Whomsley, Sophie Le Lamer, Mathieu Molimard, and Jean-Baptiste Watelet. 2009. “Pharmacokinetics in Special Populations.” Drug Metabolism Reviews 41 (3): 422–454.
APA
Poggesi, I., Benedetti, M. S., Whomsley, R., Le Lamer, S., Molimard, M., & Watelet, J.-B. (2009). Pharmacokinetics in special populations. DRUG METABOLISM REVIEWS, 41(3), 422–454.
Vancouver
1.
Poggesi I, Benedetti MS, Whomsley R, Le Lamer S, Molimard M, Watelet J-B. Pharmacokinetics in special populations. DRUG METABOLISM REVIEWS. 2009;41(3):422–54.
MLA
Poggesi, Italo, Margherita Strolin Benedetti, Rhys Whomsley, et al. “Pharmacokinetics in Special Populations.” DRUG METABOLISM REVIEWS 41.3 (2009): 422–454. Print.
@article{4324915,
  abstract     = {Pharmacokinetics are typically dependent on a variety of physiological variables (e.g., age, ethnicity, or pregnancy) or pathological conditions (e.g., renal and hepatic insufficiency, cardiac dysfunction, obesity, etc.). The influence of some of these conditions has not always been thoroughly assessed in the clinical studies of antiallergic drugs. However, the knowledge of the physiological grounds of the pharmacokinetics can provide some insight for predicting the potential alterations and guiding the initial prescription strategies. It is important to recognize that both pharmacokinetic and pharmacodynamic differences between populations should be considered. The available information on drugs used for the therapy of allergic diseases is reviewed in this chapter.},
  author       = {Poggesi, Italo and Benedetti, Margherita Strolin and Whomsley, Rhys and Le Lamer, Sophie and Molimard, Mathieu and Watelet, Jean-Baptiste},
  issn         = {0360-2532},
  journal      = {DRUG METABOLISM REVIEWS},
  keyword      = {pharmacokinetics,pharmacodynamics,Antiallergic drugs,renal impairment,hepatic impairment,demographic covariates,pregnancy,milk transfer,LIVER ALCOHOL-DEHYDROGENASE,CONGESTIVE HEART-FAILURE,CHRONIC-RENAL-FAILURE,FUROATE NASAL SPRAY,HEALTHY JAPANESE VOLUNTEERS,PERENNIAL ALLERGIC RHINITIS,HEPATIC DRUG-METABOLISM,HISTAMINE-INDUCED WHEAL,CLINICAL-PHARMACOLOGY,HUMAN PLACENTA},
  language     = {eng},
  number       = {3},
  pages        = {422--454},
  title        = {Pharmacokinetics in special populations},
  url          = {http://dx.doi.org/10.1080/10837450902891527},
  volume       = {41},
  year         = {2009},
}

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