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The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality

Stefaan Soenen (UGent) , Stefaan De Smedt (UGent) and Kevin Braeckmans (UGent)
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Abstract
The present work describes the use of a recently established multiparametric methodology to study nanomaterial toxicity. Using optimized methods, including proliferation-restricted cell types and endosomal buffer systems, the effect of different types of nanomaterials on cultured cells were studied, focusing in particular on intracellular particle degradation. Gold particles were quite resistant, whereas iron oxide degraded, with loss of magnetic resonance contrast, but little toxicity associated. Quantum dots degraded more slowly, decreasing both fluorescence quantum yield and cell viability over long-time periods. The multiparametric methodology is shown to be an efficient screening strategy, allowing easy comparison of results obtained for different nanomaterials and hereby helping to optimize nanoparticle design with improved safety.
Keywords
silica nanoparticles, iron oxide nanoparticles, gold nanoparticles, quantum dots, nanoparticles, nanotoxicity, IRON-OXIDE NANOPARTICLES, INORGANIC NANOPARTICLES, NANOMEDICINE, CYTOTOXICITY, NANOTOXICITY, GENOTOXICITY, SILVER, CELLS, GOLD

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Chicago
Soenen, Stefaan, Stefaan De Smedt, and Kevin Braeckmans. 2013. “The Biocompatibility of Nanosized Materials: Intracellular Nanoparticle Stability and Effects on Toxicity and Particle Functionality.” In Proceedings of SPIE, the International Society for Optical Engineering, ed. Wolfgang J Parak, Marek Osinski, and Kenji Yamamoto. Vol. 8595. Bellingham, WA, USA: SPIE, the International Society for Optical Engineering.
APA
Soenen, S., De Smedt, S., & Braeckmans, K. (2013). The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality. In W. J. Parak, M. Osinski, & K. Yamamoto (Eds.), Proceedings of SPIE, the International Society for Optical Engineering (Vol. 8595). Presented at the Conference on Colloidal Nanocrystals for Biomedical Applications VIII, Bellingham, WA, USA: SPIE, the International Society for Optical Engineering.
Vancouver
1.
Soenen S, De Smedt S, Braeckmans K. The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality. In: Parak WJ, Osinski M, Yamamoto K, editors. Proceedings of SPIE, the International Society for Optical Engineering. Bellingham, WA, USA: SPIE, the International Society for Optical Engineering; 2013.
MLA
Soenen, Stefaan, Stefaan De Smedt, and Kevin Braeckmans. “The Biocompatibility of Nanosized Materials: Intracellular Nanoparticle Stability and Effects on Toxicity and Particle Functionality.” Proceedings of SPIE, the International Society for Optical Engineering. Ed. Wolfgang J Parak, Marek Osinski, & Kenji Yamamoto. Vol. 8595. Bellingham, WA, USA: SPIE, the International Society for Optical Engineering, 2013. Print.
@inproceedings{4323008,
  abstract     = {The present work describes the use of a recently established multiparametric methodology to study nanomaterial toxicity. Using optimized methods, including proliferation-restricted cell types and endosomal buffer systems, the effect of different types of nanomaterials on cultured cells were studied, focusing in particular on intracellular particle degradation. Gold particles were quite resistant, whereas iron oxide degraded, with loss of magnetic resonance contrast, but little toxicity associated. Quantum dots degraded more slowly, decreasing both fluorescence quantum yield and cell viability over long-time periods. The multiparametric methodology is shown to be an efficient screening strategy, allowing easy comparison of results obtained for different nanomaterials and hereby helping to optimize nanoparticle design with improved safety.},
  articleno    = {85950D},
  author       = {Soenen, Stefaan and De Smedt, Stefaan and Braeckmans, Kevin},
  booktitle    = {Proceedings of SPIE, the International Society for Optical Engineering},
  editor       = {Parak, Wolfgang J and Osinski, Marek and Yamamoto, Kenji},
  isbn         = {9780819493644},
  issn         = {0277-786X},
  keywords     = {silica nanoparticles,iron oxide nanoparticles,gold nanoparticles,quantum dots,nanoparticles,nanotoxicity,IRON-OXIDE NANOPARTICLES,INORGANIC NANOPARTICLES,NANOMEDICINE,CYTOTOXICITY,NANOTOXICITY,GENOTOXICITY,SILVER,CELLS,GOLD},
  language     = {eng},
  location     = {San Francisco, CA, USA},
  pages        = {13},
  publisher    = {SPIE, the International Society for Optical Engineering},
  title        = {The biocompatibility of nanosized materials: intracellular nanoparticle stability and effects on toxicity and particle functionality},
  url          = {http://dx.doi.org/10.1117/12.2001098},
  volume       = {8595},
  year         = {2013},
}

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