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Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations

Ernst Rietzschel UGent, Michel Langlois UGent, Marc De Buyzere, Patrick Segers UGent, Dirk De Bacquer UGent, Sofie Bekaert UGent, Luc Cooman, Patric Van Oostveldt UGent, Pascal Verdonck UGent, Gui De Backer UGent, et al. (2008) HYPERTENSION. 52(3). p.535-541
abstract
In contrast to the plethora of vasculopathies to which oxidized low-density lipoprotein cholesterol ( ox-LDL) can be linked, there are no data linking ox-LDL to myocardial ( dys) function in the community. We tested whether ox-LDL, a marker of oxidative stress, was linked to early cardiac structural and functional damage in the general population. The Asklepios Study is a random sample of 2524 male and female volunteers, comparable to the Belgian population between 35 and 55 years free from overt cardiovascular disease. Cardiac morphology, systolic, and early and late diastolic tissue Doppler mitral annulus velocities were recorded during an echocardiography, followed by a vascular examination (carotid and femoral arteries). Serum ox- LDL was measured by sandwich ELISA using the mAb- 4E6 monoclonal antibody. Effects of ox- LDL were assessed after adjustment for age, gender, lipid fractions, blood pressure, heart rate, height, weight, glycemia, smoking, and drug treatment. Mean ox- LDL was 96.0 +/- 38.9 U/ L. After adjustment, increasing ox- LDL levels were associated with a more spherical left ventricular cavity ( minor/ major axis dimensions; P < 0.001) and decreasing diastolic ( early diastolic tissue Doppler mitral annulus velocity; P < 0.001, more pronounced in women) and systolic function ( amplitude of systolic tissue Doppler mitral annulus velocity; P = 0.008, more pronounced in men). These results remained unaffected when further adjustments were made for inflammatory markers, lifestyle, or vascular damage ( atherosclerosis and arterial stiffening). These results are the first " proof of concept" that ox- LDL impacts cardiac structure and function at a community level, independent of classic risk factors, lifestyle, inflammation, and prevalent vascular damage. Our data suggest that ox- LDL is a risk marker for early ventricular remodelling. However, the effect size in the general population is small.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
oxidative stress, systolic function, diastolic function, population sciences, oxidized LDL cholesterol, tissue Doppler imaging, cardiac echography, CONGESTIVE-HEART-FAILURE, OXIDATIVE STRESS, CARDIOVASCULAR-DISEASE, GENDER-DIFFERENCES, PRESSURE-OVERLOAD, HYPERTROPHY, OXYGEN, LDL, MEN, WOMEN
journal title
HYPERTENSION
Hypertension
volume
52
issue
3
pages
535 - 541
Web of Science type
Article
Web of Science id
000258609500018
JCR category
PERIPHERAL VASCULAR DISEASE
JCR impact factor
7.368 (2008)
JCR rank
3/56 (2008)
JCR quartile
1 (2008)
ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.108.114439
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
432249
handle
http://hdl.handle.net/1854/LU-432249
date created
2008-10-23 11:06:00
date last changed
2016-12-19 15:44:18
@article{432249,
  abstract     = {In contrast to the plethora of vasculopathies to which oxidized low-density lipoprotein cholesterol ( ox-LDL) can be linked, there are no data linking ox-LDL to myocardial ( dys) function in the community. We tested whether ox-LDL, a marker of oxidative stress, was linked to early cardiac structural and functional damage in the general population. The Asklepios Study is a random sample of 2524 male and female volunteers, comparable to the Belgian population between 35 and 55 years free from overt cardiovascular disease. Cardiac morphology, systolic, and early and late diastolic tissue Doppler mitral annulus velocities were recorded during an echocardiography, followed by a vascular examination (carotid and femoral arteries). Serum ox- LDL was measured by sandwich ELISA using the mAb- 4E6 monoclonal antibody. Effects of ox- LDL were assessed after adjustment for age, gender, lipid fractions, blood pressure, heart rate, height, weight, glycemia, smoking, and drug treatment. Mean ox- LDL was 96.0 +/- 38.9 U/ L. After adjustment, increasing ox- LDL levels were associated with a more spherical left ventricular cavity ( minor/ major axis dimensions; P {\textlangle} 0.001) and decreasing diastolic ( early diastolic tissue Doppler mitral annulus velocity; P {\textlangle} 0.001, more pronounced in women) and systolic function ( amplitude of systolic tissue Doppler mitral annulus velocity; P = 0.008, more pronounced in men). These results remained unaffected when further adjustments were made for inflammatory markers, lifestyle, or vascular damage ( atherosclerosis and arterial stiffening). These results are the first {\textacutedbl} proof of concept{\textacutedbl} that ox- LDL impacts cardiac structure and function at a community level, independent of classic risk factors, lifestyle, inflammation, and prevalent vascular damage. Our data suggest that ox- LDL is a risk marker for early ventricular remodelling. However, the effect size in the general population is small.},
  author       = {Rietzschel, Ernst and Langlois, Michel and De Buyzere, Marc and Segers, Patrick and De Bacquer, Dirk and Bekaert, Sofie and Cooman, Luc and Van Oostveldt, Patric and Verdonck, Pascal and De Backer, Gui and Gillebert, Thierry},
  issn         = {0194-911X},
  journal      = {HYPERTENSION},
  keyword      = {oxidative stress,systolic function,diastolic function,population sciences,oxidized LDL cholesterol,tissue Doppler imaging,cardiac echography,CONGESTIVE-HEART-FAILURE,OXIDATIVE STRESS,CARDIOVASCULAR-DISEASE,GENDER-DIFFERENCES,PRESSURE-OVERLOAD,HYPERTROPHY,OXYGEN,LDL,MEN,WOMEN},
  language     = {eng},
  number       = {3},
  pages        = {535--541},
  title        = {Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.114439},
  volume       = {52},
  year         = {2008},
}

Chicago
Rietzschel, Ernst, Michel Langlois, MARC DE BUYZERE, Patrick Segers, Dirk De Bacquer, Sofie Bekaert, Luc Cooman, et al. 2008. “Oxidized Low-density Lipoprotein Cholesterol Is Associated with Decreases in Cardiac Function Independent of Vascular Alterations.” Hypertension 52 (3): 535–541.
APA
Rietzschel, E., Langlois, M., DE BUYZERE, M., Segers, P., De Bacquer, D., Bekaert, S., Cooman, L., et al. (2008). Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations. HYPERTENSION, 52(3), 535–541.
Vancouver
1.
Rietzschel E, Langlois M, DE BUYZERE M, Segers P, De Bacquer D, Bekaert S, et al. Oxidized low-density lipoprotein cholesterol is associated with decreases in cardiac function independent of vascular alterations. HYPERTENSION. 2008;52(3):535–41.
MLA
Rietzschel, Ernst, Michel Langlois, MARC DE BUYZERE, et al. “Oxidized Low-density Lipoprotein Cholesterol Is Associated with Decreases in Cardiac Function Independent of Vascular Alterations.” HYPERTENSION 52.3 (2008): 535–541. Print.