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A20 in inflammation and autoimmunity

Leen Catrysse (UGent) , Lars Vereecke (UGent) , Rudi Beyaert (UGent) and Geert van Loo (UGent)
(2014) TRENDS IN IMMUNOLOGY. 35(1). p.22-31
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Although known for many years as a nuclear factor (NF)-kappa B inhibitory and antiapoptotic signaling protein, A20 has recently attracted much attention because of its ubiquitin-regulatory activities and qualification by genome-wide association studies (GWASs) as a susceptibility gene for inflammatory disease. Here, we review new findings that have shed light on the molecular and biochemical mechanisms by which A20 regulates inflammatory signaling cascades, and discuss recent experimental evidence characterizing A20 as a crucial gatekeeper preserving tissue homeostasis.
Keywords
apoptosis, ubiquitination, NF-KAPPA-B, EDITING ENZYME A20, ZINC-FINGER PROTEIN, tumor necrosis factor alpha-induced protein 3, A20, nuclear factor-kappa B, inflammation, SYSTEMIC-LUPUS-ERYTHEMATOSUS, RHEUMATOID-ARTHRITIS, CELL-PROLIFERATION, LINEAR UBIQUITINATION, FEEDBACK INHIBITION, IMMUNE HOMEOSTASIS, NEGATIVE REGULATOR

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Citation

Please use this url to cite or link to this publication:

Chicago
Catrysse, Leen, Lars Vereecke, Rudi Beyaert, and Geert van Loo. 2014. “A20 in Inflammation and Autoimmunity.” Trends in Immunology 35 (1): 22–31.
APA
Catrysse, L., Vereecke, L., Beyaert, R., & van Loo, G. (2014). A20 in inflammation and autoimmunity. TRENDS IN IMMUNOLOGY, 35(1), 22–31.
Vancouver
1.
Catrysse L, Vereecke L, Beyaert R, van Loo G. A20 in inflammation and autoimmunity. TRENDS IN IMMUNOLOGY. 2014;35(1):22–31.
MLA
Catrysse, Leen, Lars Vereecke, Rudi Beyaert, et al. “A20 in Inflammation and Autoimmunity.” TRENDS IN IMMUNOLOGY 35.1 (2014): 22–31. Print.
@article{4322445,
  abstract     = {Although known for many years as a nuclear factor (NF)-kappa B inhibitory and antiapoptotic signaling protein, A20 has recently attracted much attention because of its ubiquitin-regulatory activities and qualification by genome-wide association studies (GWASs) as a susceptibility gene for inflammatory disease. Here, we review new findings that have shed light on the molecular and biochemical mechanisms by which A20 regulates inflammatory signaling cascades, and discuss recent experimental evidence characterizing A20 as a crucial gatekeeper preserving tissue homeostasis.},
  author       = {Catrysse, Leen and Vereecke, Lars and Beyaert, Rudi and van Loo, Geert},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {22--31},
  title        = {A20 in inflammation and autoimmunity},
  url          = {http://dx.doi.org/10.1016/j.it.2013.10.005},
  volume       = {35},
  year         = {2014},
}

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