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EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22)

An De Weer UGent, Bruce Poppe UGent, Barbara Cauwelier, A CARLIER, J DIERICK, Bruno Verhasselt UGent, Jan Philippé UGent, Nadine Van Roy UGent and Franki Speleman UGent (2008) BMC CANCER. 8.
abstract
Background: Variant translocations t( 9; 22) occur in 5 to 10% of newly diagnosed CMLs and additional genetic changes are present in 60 - 80% of patients in blast crisis ( BC). Here, we report on a CML patient in blast crisis presenting with a four-way variant t( 9; 22) rearrangement involving the EVII locus. Methods: Dual-colour Fluorescence In Situ Hybridisation was performed to unravel the different cytogenetic aberrations. Expression levels of EVII and BCR/ABLI were investigated using real-time quantitative RT-PCR. Results: In this paper we identified a patient with a complex 4-way t(3; 9; 17; 22) which, in addition to BCR/ABLI gene fusion, also resulted in EVII rearrangement and overexpression. Conclusion: This report illustrates how a variant t( 9; 22) translocation can specifically target a second oncogene most likely contributing to the more aggressive phenotype of the disease. Molecular analysis of such variants is thus warranted to understand the phenotypic consequences and to open the way for combined molecular therapies in order to tackle the secondary oncogenic effect which is unresponsive to imatinib treatment.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CHRONIC MYELOID-LEUKEMIA, ONCOGENE, EXPRESSION, DISEASE, AML
journal title
BMC CANCER
BMC Cancer
volume
8
pages
- pages
Web of Science type
Article
Web of Science id
000257688500001
JCR category
ONCOLOGY
JCR impact factor
3.087 (2008)
JCR rank
59/141 (2008)
JCR quartile
2 (2008)
ISSN
1471-2407
DOI
10.1186/1471-2407-8-193
language
English
UGent publication?
yes
classification
A1
id
432138
handle
http://hdl.handle.net/1854/LU-432138
date created
2008-10-22 13:00:00
date last changed
2015-06-17 11:03:26
@article{432138,
  abstract     = {Background: Variant translocations t( 9; 22) occur in 5 to 10\% of newly diagnosed CMLs and additional genetic changes are present in 60 - 80\% of patients in blast crisis ( BC). Here, we report on a CML patient in blast crisis presenting with a four-way variant t( 9; 22) rearrangement involving the EVII locus. 

Methods: Dual-colour Fluorescence In Situ Hybridisation was performed to unravel the different cytogenetic aberrations. Expression levels of EVII and BCR/ABLI were investigated using real-time quantitative RT-PCR. 

Results: In this paper we identified a patient with a complex 4-way t(3; 9; 17; 22) which, in addition to BCR/ABLI gene fusion, also resulted in EVII rearrangement and overexpression. 

Conclusion: This report illustrates how a variant t( 9; 22) translocation can specifically target a second oncogene most likely contributing to the more aggressive phenotype of the disease. Molecular analysis of such variants is thus warranted to understand the phenotypic consequences and to open the way for combined molecular therapies in order to tackle the secondary oncogenic effect which is unresponsive to imatinib treatment.},
  author       = {De Weer, An and Poppe, Bruce and Cauwelier, Barbara and CARLIER, A and DIERICK, J and Verhasselt, Bruno and Philipp{\'e}, Jan and Van Roy, Nadine and Speleman, Franki},
  issn         = {1471-2407},
  journal      = {BMC CANCER},
  keyword      = {CHRONIC MYELOID-LEUKEMIA,ONCOGENE,EXPRESSION,DISEASE,AML},
  language     = {eng},
  pages        = {-},
  title        = {EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22)},
  url          = {http://dx.doi.org/10.1186/1471-2407-8-193},
  volume       = {8},
  year         = {2008},
}

Chicago
De Weer, An, Bruce Poppe, Barbara Cauwelier, A CARLIER, J DIERICK, Bruno Verhasselt, Jan Philippé, Nadine Van Roy, and Franki Speleman. 2008. “EVII Activation in Blast Crisis CML Due to Juxtaposition to the Rare 17q22 Partner Region as Part of a 4-way Variant Translocation T(9;22).” Bmc Cancer 8.
APA
De Weer, An, Poppe, B., Cauwelier, B., CARLIER, A., DIERICK, J., Verhasselt, B., Philippé, J., et al. (2008). EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22). BMC CANCER, 8.
Vancouver
1.
De Weer A, Poppe B, Cauwelier B, CARLIER A, DIERICK J, Verhasselt B, et al. EVII activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22). BMC CANCER. 2008;8.
MLA
De Weer, An, Bruce Poppe, Barbara Cauwelier, et al. “EVII Activation in Blast Crisis CML Due to Juxtaposition to the Rare 17q22 Partner Region as Part of a 4-way Variant Translocation T(9;22).” BMC CANCER 8 (2008): n. pag. Print.