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Bimanual motor coordination in older adults is associated with increased functional brain connectivity: a graph-theoretical analysis

(2013) PLOS ONE. 8(4).
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Organization
Abstract
In bimanual coordination, older and younger adults activate a common cerebral network but the elderly also have additional activation in a secondary network of brain areas to master task performance. It remains unclear whether the functional connectivity within these primary and secondary motor networks differs between the old and the young and whether task difficulty modulates connectivity. We applied graph-theoretical network analysis (GTNA) to task-driven fMRI data in 16 elderly and 16 young participants using a bimanual coordination task including in-phase and anti-phase flexion/extension wrist movements. Network nodes for the GTNA comprised task-relevant brain areas as defined by fMRI activation foci. The elderly matched the motor performance of the young but showed an increased functional connectivity in both networks across a wide range of connectivity metrics, i.e., higher mean connectivity degree, connection strength, network density and efficiency, together with shorter mean communication path length between the network nodes and also a lower betweenness centrality. More difficult movements showed an increased connectivity in both groups. The network connectivity of both groups had "small world'' character. The present findings indicate (a) that bimanual coordination in the aging brain is associated with a higher functional connectivity even between areas also activated in young adults, independently from task difficulty, and (b) that adequate motor coordination in the context of task-driven bimanual control in older adults may not be solely due to additional neural recruitment but also to aging-related changes of functional relationships between brain regions
Keywords
SMALL-WORLD NETWORKS, AGE-RELATED-CHANGES, RESTING-STATE, PERFORMANCE, MEMORY, FMRI, SYSTEMS, MODULATION, ANISOTROPY, AGING BRAIN

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MLA
Heitger, Marcus H et al. “Bimanual Motor Coordination in Older Adults Is Associated with Increased Functional Brain Connectivity: a Graph-theoretical Analysis.” PLOS ONE 8.4 (2013): n. pag. Print.
APA
Heitger, M. H., Goble, D. J., Dhollander, T., Dupont, P., Caeyenberghs, K., Leemans, A., Sunaert, S., et al. (2013). Bimanual motor coordination in older adults is associated with increased functional brain connectivity: a graph-theoretical analysis. PLOS ONE, 8(4).
Chicago author-date
Heitger, Marcus H, Daniel J Goble, Thijs Dhollander, Patrick Dupont, Karen Caeyenberghs, Alexander Leemans, Stefan Sunaert, and Stephan P Swinnen. 2013. “Bimanual Motor Coordination in Older Adults Is Associated with Increased Functional Brain Connectivity: a Graph-theoretical Analysis.” Plos One 8 (4).
Chicago author-date (all authors)
Heitger, Marcus H, Daniel J Goble, Thijs Dhollander, Patrick Dupont, Karen Caeyenberghs, Alexander Leemans, Stefan Sunaert, and Stephan P Swinnen. 2013. “Bimanual Motor Coordination in Older Adults Is Associated with Increased Functional Brain Connectivity: a Graph-theoretical Analysis.” Plos One 8 (4).
Vancouver
1.
Heitger MH, Goble DJ, Dhollander T, Dupont P, Caeyenberghs K, Leemans A, et al. Bimanual motor coordination in older adults is associated with increased functional brain connectivity: a graph-theoretical analysis. PLOS ONE. 2013;8(4).
IEEE
[1]
M. H. Heitger et al., “Bimanual motor coordination in older adults is associated with increased functional brain connectivity: a graph-theoretical analysis,” PLOS ONE, vol. 8, no. 4, 2013.
@article{4318494,
  abstract     = {In bimanual coordination, older and younger adults activate a common cerebral network but the elderly also have additional activation in a secondary network of brain areas to master task performance. It remains unclear whether the functional connectivity within these primary and secondary motor networks differs between the old and the young and whether task difficulty modulates connectivity. We applied graph-theoretical network analysis (GTNA) to task-driven fMRI data in 16 elderly and 16 young participants using a bimanual coordination task including in-phase and anti-phase flexion/extension wrist movements. Network nodes for the GTNA comprised task-relevant brain areas as defined by fMRI activation foci. The elderly matched the motor performance of the young but showed an increased functional connectivity in both networks across a wide range of connectivity metrics, i.e., higher mean connectivity degree, connection strength, network density and efficiency, together with shorter mean communication path length between the network nodes and also a lower betweenness centrality. More difficult movements showed an increased connectivity in both groups. The network connectivity of both groups had "small world'' character. The present findings indicate (a) that bimanual coordination in the aging brain is associated with a higher functional connectivity even between areas also activated in young adults, independently from task difficulty, and (b) that adequate motor coordination in the context of task-driven bimanual control in older adults may not be solely due to additional neural recruitment but also to aging-related changes of functional relationships between brain regions},
  articleno    = {e62133},
  author       = {Heitger, Marcus H and Goble, Daniel J and Dhollander, Thijs and Dupont, Patrick and Caeyenberghs, Karen and Leemans, Alexander and Sunaert, Stefan and Swinnen, Stephan P},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {SMALL-WORLD NETWORKS,AGE-RELATED-CHANGES,RESTING-STATE,PERFORMANCE,MEMORY,FMRI,SYSTEMS,MODULATION,ANISOTROPY,AGING BRAIN},
  language     = {eng},
  number       = {4},
  pages        = {16},
  title        = {Bimanual motor coordination in older adults is associated with increased functional brain connectivity: a graph-theoretical analysis},
  url          = {http://dx.doi.org/10.1371/journal.pone.0062133},
  volume       = {8},
  year         = {2013},
}

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