Proteomics in liver fibrosis is more than meets the eye
- Author
- Kin Jip Cheung (UGent) , Kelly Tilleman (UGent) , Dieter Deforce (UGent) , Isabelle Colle (UGent) and Hans Van Vlierberghe (UGent)
- Organization
- Abstract
- Liver fibrosis is a serious health issue for many liver patients and is currently diagnosed using liver biopsy. The erroneous nature of this technique urges the search for better, noninvasive alternatives. In this regard, proteomics has been described as a useful biomarker discovery tool and has become increasingly applied in the study of liver fibrosis. Experimental and clinical studies have already provided deeper insights in the molecular pathways of liver fibrosis and even confirmed previous findings. Recent advances in proteomic strategies and tools enable multiple fractionation, multiple protein identifications and parallel analyses of multiple samples. Despite its increasing popularity, proteomics still faces certain pitfalls concerning preanalytical variability, protein coverage and statistic reliability. Proteomics is still evolving, but will undoubtedly contribute to a better understanding of the basis of the pathology and certainly offer opportunities in liver fibrosis diagnostics and therapeutics.
- Keywords
- HEPATOCELLULAR-CARCINOMA, HUMAN SERUM PROTEOME, QUANTITATIVE PROTEOMICS, SAMPLING VARIABILITY, MASS-SPECTROMETRY, VIRUS-INFECTION, NONALCOHOLIC STEATOHEPATITIS, 2-DIMENSIONAL GEL-ELECTROPHORESIS, STELLATE CELL ACTIVATION, CHRONIC HEPATITIS-C, serum, proteomics, proteins, liver fibrosis, liver biopsy, extracellular matrix, biomarker
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-431829
- MLA
- Cheung, Kin Jip, et al. “Proteomics in Liver Fibrosis Is More than Meets the Eye.” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol. 20, no. 5, 2008, pp. 450–64, doi:10.1097/MEG.0b013e3282f4de92.
- APA
- Cheung, K. J., Tilleman, K., Deforce, D., Colle, I., & Van Vlierberghe, H. (2008). Proteomics in liver fibrosis is more than meets the eye. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 20(5), 450–464. https://doi.org/10.1097/MEG.0b013e3282f4de92
- Chicago author-date
- Cheung, Kin Jip, Kelly Tilleman, Dieter Deforce, Isabelle Colle, and Hans Van Vlierberghe. 2008. “Proteomics in Liver Fibrosis Is More than Meets the Eye.” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 20 (5): 450–64. https://doi.org/10.1097/MEG.0b013e3282f4de92.
- Chicago author-date (all authors)
- Cheung, Kin Jip, Kelly Tilleman, Dieter Deforce, Isabelle Colle, and Hans Van Vlierberghe. 2008. “Proteomics in Liver Fibrosis Is More than Meets the Eye.” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 20 (5): 450–464. doi:10.1097/MEG.0b013e3282f4de92.
- Vancouver
- 1.Cheung KJ, Tilleman K, Deforce D, Colle I, Van Vlierberghe H. Proteomics in liver fibrosis is more than meets the eye. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. 2008;20(5):450–64.
- IEEE
- [1]K. J. Cheung, K. Tilleman, D. Deforce, I. Colle, and H. Van Vlierberghe, “Proteomics in liver fibrosis is more than meets the eye,” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol. 20, no. 5, pp. 450–464, 2008.
@article{431829, abstract = {{Liver fibrosis is a serious health issue for many liver patients and is currently diagnosed using liver biopsy. The erroneous nature of this technique urges the search for better, noninvasive alternatives. In this regard, proteomics has been described as a useful biomarker discovery tool and has become increasingly applied in the study of liver fibrosis. Experimental and clinical studies have already provided deeper insights in the molecular pathways of liver fibrosis and even confirmed previous findings. Recent advances in proteomic strategies and tools enable multiple fractionation, multiple protein identifications and parallel analyses of multiple samples. Despite its increasing popularity, proteomics still faces certain pitfalls concerning preanalytical variability, protein coverage and statistic reliability. Proteomics is still evolving, but will undoubtedly contribute to a better understanding of the basis of the pathology and certainly offer opportunities in liver fibrosis diagnostics and therapeutics.}}, author = {{Cheung, Kin Jip and Tilleman, Kelly and Deforce, Dieter and Colle, Isabelle and Van Vlierberghe, Hans}}, issn = {{0954-691X}}, journal = {{EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY}}, keywords = {{HEPATOCELLULAR-CARCINOMA,HUMAN SERUM PROTEOME,QUANTITATIVE PROTEOMICS,SAMPLING VARIABILITY,MASS-SPECTROMETRY,VIRUS-INFECTION,NONALCOHOLIC STEATOHEPATITIS,2-DIMENSIONAL GEL-ELECTROPHORESIS,STELLATE CELL ACTIVATION,CHRONIC HEPATITIS-C,serum,proteomics,proteins,liver fibrosis,liver biopsy,extracellular matrix,biomarker}}, language = {{eng}}, number = {{5}}, pages = {{450--464}}, title = {{Proteomics in liver fibrosis is more than meets the eye}}, url = {{http://doi.org/10.1097/MEG.0b013e3282f4de92}}, volume = {{20}}, year = {{2008}}, }
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