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Proteomics in liver fibrosis is more than meets the eye

Kin Jip Cheung (UGent) , Kelly Tilleman (UGent) , Dieter Deforce (UGent) , Isabelle Colle (UGent) and Hans Van Vlierberghe (UGent)
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Abstract
Liver fibrosis is a serious health issue for many liver patients and is currently diagnosed using liver biopsy. The erroneous nature of this technique urges the search for better, noninvasive alternatives. In this regard, proteomics has been described as a useful biomarker discovery tool and has become increasingly applied in the study of liver fibrosis. Experimental and clinical studies have already provided deeper insights in the molecular pathways of liver fibrosis and even confirmed previous findings. Recent advances in proteomic strategies and tools enable multiple fractionation, multiple protein identifications and parallel analyses of multiple samples. Despite its increasing popularity, proteomics still faces certain pitfalls concerning preanalytical variability, protein coverage and statistic reliability. Proteomics is still evolving, but will undoubtedly contribute to a better understanding of the basis of the pathology and certainly offer opportunities in liver fibrosis diagnostics and therapeutics.
Keywords
HEPATOCELLULAR-CARCINOMA, HUMAN SERUM PROTEOME, QUANTITATIVE PROTEOMICS, SAMPLING VARIABILITY, MASS-SPECTROMETRY, VIRUS-INFECTION, NONALCOHOLIC STEATOHEPATITIS, 2-DIMENSIONAL GEL-ELECTROPHORESIS, STELLATE CELL ACTIVATION, CHRONIC HEPATITIS-C, serum, proteomics, proteins, liver fibrosis, liver biopsy, extracellular matrix, biomarker

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MLA
Cheung, Kin Jip, et al. “Proteomics in Liver Fibrosis Is More than Meets the Eye.” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol. 20, no. 5, 2008, pp. 450–64, doi:10.1097/MEG.0b013e3282f4de92.
APA
Cheung, K. J., Tilleman, K., Deforce, D., Colle, I., & Van Vlierberghe, H. (2008). Proteomics in liver fibrosis is more than meets the eye. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 20(5), 450–464. https://doi.org/10.1097/MEG.0b013e3282f4de92
Chicago author-date
Cheung, Kin Jip, Kelly Tilleman, Dieter Deforce, Isabelle Colle, and Hans Van Vlierberghe. 2008. “Proteomics in Liver Fibrosis Is More than Meets the Eye.” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 20 (5): 450–64. https://doi.org/10.1097/MEG.0b013e3282f4de92.
Chicago author-date (all authors)
Cheung, Kin Jip, Kelly Tilleman, Dieter Deforce, Isabelle Colle, and Hans Van Vlierberghe. 2008. “Proteomics in Liver Fibrosis Is More than Meets the Eye.” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 20 (5): 450–464. doi:10.1097/MEG.0b013e3282f4de92.
Vancouver
1.
Cheung KJ, Tilleman K, Deforce D, Colle I, Van Vlierberghe H. Proteomics in liver fibrosis is more than meets the eye. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. 2008;20(5):450–64.
IEEE
[1]
K. J. Cheung, K. Tilleman, D. Deforce, I. Colle, and H. Van Vlierberghe, “Proteomics in liver fibrosis is more than meets the eye,” EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol. 20, no. 5, pp. 450–464, 2008.
@article{431829,
  abstract     = {{Liver fibrosis is a serious health issue for many liver patients and is currently diagnosed using liver biopsy. The erroneous nature of this technique urges the search for better, noninvasive alternatives. In this regard, proteomics has been described as a useful biomarker discovery tool and has become increasingly applied in the study of liver fibrosis. Experimental and clinical studies have already provided deeper insights in the molecular pathways of liver fibrosis and even confirmed previous findings. Recent advances in proteomic strategies and tools enable multiple fractionation, multiple protein identifications and parallel analyses of multiple samples. Despite its increasing popularity, proteomics still faces certain pitfalls concerning preanalytical variability, protein coverage and statistic reliability. Proteomics is still evolving, but will undoubtedly contribute to a better understanding of the basis of the pathology and certainly offer opportunities in liver fibrosis diagnostics and therapeutics.}},
  author       = {{Cheung, Kin Jip and Tilleman, Kelly and Deforce, Dieter and Colle, Isabelle and Van Vlierberghe, Hans}},
  issn         = {{0954-691X}},
  journal      = {{EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY}},
  keywords     = {{HEPATOCELLULAR-CARCINOMA,HUMAN SERUM PROTEOME,QUANTITATIVE PROTEOMICS,SAMPLING VARIABILITY,MASS-SPECTROMETRY,VIRUS-INFECTION,NONALCOHOLIC STEATOHEPATITIS,2-DIMENSIONAL GEL-ELECTROPHORESIS,STELLATE CELL ACTIVATION,CHRONIC HEPATITIS-C,serum,proteomics,proteins,liver fibrosis,liver biopsy,extracellular matrix,biomarker}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{450--464}},
  title        = {{Proteomics in liver fibrosis is more than meets the eye}},
  url          = {{http://doi.org/10.1097/MEG.0b013e3282f4de92}},
  volume       = {{20}},
  year         = {{2008}},
}

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