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Toxin–antitoxin systems: their role in persistence, biofilm formation, and pathogenicity

Yurong Wen (UGent) , Ester Behiels (UGent) and Bart Devreese (UGent)
(2014) PATHOGENS AND DISEASE. 70(3). p.240-249
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Abstract
One of the most pertinent recent outcomes of molecular microbiology efforts to understand bacterial behavior is the discovery of a wide range of toxin–antitoxin (TA) systems that are tightly controlling bacterial persistence. While TA systems were originally linked to control over the genetic material, for example plasmid maintenance, it is now clear that they are involved in essential cellular processes like replication, gene expression, and cell wall synthesis. Toxin activity is induced stochastically or after environmental stimuli, resulting in silencing of the above-mentioned biological processes and entry in a dormant state. In this minireview, we highlight the recent developments in research on these intriguing systems with a focus on their role in biofilms and in bacterial virulence. We discuss their potential as targets in antimicrobial drug discovery.
Keywords
microbiology, biofilm, antibiotic resistance., cell death, ESCHERICHIA-COLI K-12, MESSENGER-RNA CLEAVAGE, PROGRAMMED CELL-DEATH, BACTERIAL PERSISTENCE, MULTIDRUG TOLERANCE, STAPHYLOCOCCUS-AUREUS, MOLECULAR-MECHANISMS, PLASMID MAINTENANCE, MICROBIAL BIOFILMS, PROTEIN-SYNTHESIS

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Citation

Please use this url to cite or link to this publication:

MLA
Wen, Yurong, Ester Behiels, and Bart Devreese. “Toxin–antitoxin Systems: Their Role in Persistence, Biofilm Formation, and Pathogenicity.” PATHOGENS AND DISEASE 70.3 (2014): 240–249. Print.
APA
Wen, Y., Behiels, E., & Devreese, B. (2014). Toxin–antitoxin systems: their role in persistence, biofilm formation, and pathogenicity. PATHOGENS AND DISEASE, 70(3), 240–249.
Chicago author-date
Wen, Yurong, Ester Behiels, and Bart Devreese. 2014. “Toxin–antitoxin Systems: Their Role in Persistence, Biofilm Formation, and Pathogenicity.” Pathogens and Disease 70 (3): 240–249.
Chicago author-date (all authors)
Wen, Yurong, Ester Behiels, and Bart Devreese. 2014. “Toxin–antitoxin Systems: Their Role in Persistence, Biofilm Formation, and Pathogenicity.” Pathogens and Disease 70 (3): 240–249.
Vancouver
1.
Wen Y, Behiels E, Devreese B. Toxin–antitoxin systems: their role in persistence, biofilm formation, and pathogenicity. PATHOGENS AND DISEASE. 2014;70(3):240–9.
IEEE
[1]
Y. Wen, E. Behiels, and B. Devreese, “Toxin–antitoxin systems: their role in persistence, biofilm formation, and pathogenicity,” PATHOGENS AND DISEASE, vol. 70, no. 3, pp. 240–249, 2014.
@article{4316775,
  abstract     = {One of the most pertinent recent outcomes of molecular microbiology efforts to understand bacterial behavior is the discovery of a wide range of toxin–antitoxin (TA) systems that are tightly controlling bacterial persistence. While TA systems were originally linked to control over the genetic material, for example plasmid maintenance, it is now clear that they are involved in essential cellular processes like replication, gene expression, and cell wall synthesis. Toxin activity is induced stochastically or after environmental stimuli, resulting in silencing of the above-mentioned biological processes and entry in a dormant state. In this minireview, we highlight the recent developments in research on these intriguing systems with a focus on their role in biofilms and in bacterial virulence. We discuss their potential as targets in antimicrobial drug discovery.},
  author       = {Wen, Yurong and Behiels, Ester and Devreese, Bart},
  issn         = {2049-632X},
  journal      = {PATHOGENS AND DISEASE},
  keywords     = {microbiology,biofilm,antibiotic resistance.,cell death,ESCHERICHIA-COLI K-12,MESSENGER-RNA CLEAVAGE,PROGRAMMED CELL-DEATH,BACTERIAL PERSISTENCE,MULTIDRUG TOLERANCE,STAPHYLOCOCCUS-AUREUS,MOLECULAR-MECHANISMS,PLASMID MAINTENANCE,MICROBIAL BIOFILMS,PROTEIN-SYNTHESIS},
  language     = {eng},
  number       = {3},
  pages        = {240--249},
  title        = {Toxin–antitoxin systems: their role in persistence, biofilm formation, and pathogenicity},
  url          = {http://dx.doi.org/10.1111/2049-632X.12145},
  volume       = {70},
  year         = {2014},
}

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