@article{4314940,
  abstract     = {{Context: Traditional medicinal plants have long been used in Ethiopia to treat human and livestock ailments. Despite a well-documented rich tradition of medicinal plant use in the country, their direct antimicrobial effects are still poorly known. 
Objective: To investigate the antimicrobial activity of 19 medicinal plant species that were selected based on the ethnobotanical information on their traditional use to treat infectious diseases in Ankober District. 
Methods: About 23 different ethanol extracts of plants obtained by maceration of various parts of 19 medicinal plant species were studied for potential antimicrobial activity using a broth microdilution method against Bacillus cereus, Bacteroides fragilis, Candida albicans, Clostridium perfringens, Enterococcus faecalis, Escherichia coli, Listeria monocytogenes, Pseudomonas aeruginosa, Salmonella enteritidis, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes. 
Results: Plant extracts from Embelia schimperi Vatke (Myrsinaceae) showed the strongest antibacterial activity with a minimum inhibitory concentration (MIC) value of 64 mu g/ml against B. cereus, L. monocytogenes, and S. pyogenes. Growth inhibitory activities were also observed for extracts of Ocimum lamiifolium Hochst. (Lamiaceae) against S. pyogenes, and those of Rubus steudneri Schweinf. (Rosaceae) against S. epidermidis at an MIC value of 128 mu g/ml. Generally, 74% of ethanol extracts (17 extracts) showed antimicrobial activity against one or more of the microbial strains tested at an MIC value of 512 mu g/ml or below. 
Discussion and conclusions: Results confirm the antimicrobial role of traditional medicinal plants of Ankober and warrant further investigations on promising medicinal plant species so as to isolate and characterise chemicals responsible for the observed strong antimicrobial activities.}},
  author       = {{Molla, Ermias Lulekal and Rondevaldova, J and Bernaskova, E and Cepkova, J and Asfaw, Z and Kelbessa, E and Kokoska, L and Van Damme, Patrick}},
  issn         = {{1388-0209}},
  journal      = {{PHARMACEUTICAL BIOLOGY}},
  keywords     = {{ethnomedicine,plant extracts,activity testing,HAEMONCHUS-CONTORTUS,EMBELIA-SCHIMPERI LEAVES,CRUDE EXTRACTS,ESSENTIAL OILS,ETHNIC-GROUP,IN-VITRO,VERNONIA-AMYGDALINA,OCIMUM-LAMIIFOLIUM,MOUNTAINS-NATIONAL-PARK,ANTIBACTERIAL}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{614--620}},
  title        = {{Antimicrobial activity of traditional medicinal plants from Ankober District, North Shewa Zone, Amhara Region, Ethiopia}},
  url          = {{http://doi.org/10.3109/13880209.2013.858362}},
  volume       = {{52}},
  year         = {{2014}},
}

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