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Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana

(1999) NATURE. 402(6763). p.769-777
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Abstract
The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996, Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency of a variety of repeats, new repeats, reduced recombination, lowered gene density and lowered gene expression. Roughly 60% of the predicted protein-coding genes have been functionally characterized on the basis of their homology to known genes. Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.
Keywords
PREDICTION, TELOMERE, FISSION YEAST, DNA-SEQUENCES, GENOMIC DNA, MODEL-PLANT, REGIONS, RFLP, RNA, RECOMBINATION

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Chicago
Mayer, K, C Schüller, R Wambutt, G Murphy, G Volckaert, T Pohl, A Düsterhöft, et al. 1999. “Sequence and Analysis of Chromosome 4 of the Plant Arabidopsis Thaliana.” Nature 402 (6763): 769–777.
APA
Mayer, K, Schüller, C., Wambutt, R., Murphy, G., Volckaert, G., Pohl, T., Düsterhöft, A., et al. (1999). Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. NATURE, 402(6763), 769–777.
Vancouver
1.
Mayer K, Schüller C, Wambutt R, Murphy G, Volckaert G, Pohl T, et al. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. NATURE. 1999;402(6763):769–77.
MLA
Mayer, K, C Schüller, R Wambutt, et al. “Sequence and Analysis of Chromosome 4 of the Plant Arabidopsis Thaliana.” NATURE 402.6763 (1999): 769–777. Print.
@article{431188,
  abstract     = {The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996, Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17\% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency of a variety of repeats, new repeats, reduced recombination, lowered gene density and lowered gene expression. Roughly 60\% of the predicted protein-coding genes have been functionally characterized on the basis of their homology to known genes. Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.},
  author       = {Mayer, K and Sch{\"u}ller, C and Wambutt, R and Murphy, G and Volckaert, G and Pohl, T and D{\"u}sterh{\"o}ft, A and Stiekema, W and Entian, K-D and Terryn, Nancy and Harris, B and Ansorge, W and Brandt, P and Grivell, L and Rieger, M and Weichselgartner, M and de Simone, V and Obermaier, B and Mache, R and M{\"u}ller, M and Kreis, M and Delseny, M and Puigdomenech, P and Watsone, M and Schmidtheini, T and Reichert, B and Portatelle, D and Perez-Alonso, M and Boutry, M and Bancroft, I and Vos, P and Hoheisel, J and Zimmerman, W and Wedler, H and Ridley, P and Langham, S-A and McCullagh, B and Bilham, L and Robben, J and Van der Schueren, J and Grymonprez, B and Chuang, Y-J and Vandenbussche, F and Braeken, M and Weltjens, I and Voet, M and Bastiaens, I and Aert, R and Defoor, E and Weitzenegger, T and Bothe, G and Ramsperger, U and Hilbert, H and Braun, M and Holzer, E and Brandt, A and Peters, S and van Staveren, M and Dirkse, W and Mooijman, P and Lankhorst, RK and Rose, M and Hauf, J and K{\"o}tter, P and Berneiser, S and Hempel, S and Feldpausch, M and Lamberth, S and Van Den Daele, Hilde and De Keyser, Annick and Buysschaert, C and Gielen, Jan and Villarroel-Mandiola, Raimundo and De Clercq, Rebecca and Van Montagu, Marc and Rogers, J and Cronin, A and Quail, M and Bray-Allen, S and Clark, L and Doggett, J and Hall, S and Kay, M and Lennard, N and McLay, K and Mayes, R and Pettett, A and Rajandream, M-A and Lyne, M and Benes, V and Rechmann, S and Borkova, D and Bl{\"o}cker, H and Scharfe, M and Grimm, M and L{\"o}hnert, T-H and Dose, S and de Haan, M and Maarse, A and Sch{\"a}fer, M and M{\"u}ller-Auer, S and Gabel, C and Fuchs, M and Fartmann, B and Granderath, K and Dauner, D and Herzl, A and Neumann, S and Argiriou, A and Vitale, D and Liguori, R and Piravandi, E and Massenet, O and Quigley, F and Clabauld, G and M{\"u}ndlein, A and Felber, R and Schnabl, S and Hiller, R and Schmidt, W and Lecharny, A and Aubourg, S and Chefdor, F and Cooke, R and Berger, C and Montfort, A and Casacuberta, E and Gibbons, T and Weber, N and Vandenbol, M and Bargues, M and Terol, J and Torres, A and Perez-Perez, A and Purnelle, B and Bent, E and Johnson, S and Tacon, D and Jesse, T and Heijnen, L and Schwarz, S and Scholler, P and Heber, S and Francs, P and Bielke, C and Frishman, D and Haase, D and Lemcke, K and Mewes, HW and Stocker, S and Zaccaria, P and Bevan, M and Wilson, RK and de la Bastide, M and Habermann, K and Parnell, L and Dedhia, N and Gnoj, L and Schutz, K and Huang, E and Spiegel, L and Sehkon, M and Murray, J and Sheet, P and Cordes, M and Abu-Threideh, J and Stoneking, T and Kalicki, J and Graves, T and Harmon, G and Edwards, J and Latreille, P and Courtney, L and Cloud, J and Abbott, A and Scott, K and Johnson, D and Minx, P and Bentley, D and Fulton, B and Miller, N and Greco, T and Kemp, K and Kramer, J and Fulton, L and Mardis, E and Dante, M and Pepin, K and Hillier, L and Nelson, J and Spieth, J and Ryan, E and Andrews, S and Geisel, C and Layman, D and Du, H and Ali, J and Berghoff, A and Jones, K and Drone, K and Cotton, M and Joshu, C and Antonoiu, B and Zidanic, M and Strong, C and Sun, H and Lamar, B and Yordan, C and Ma, P and Zhong, J and Preston, R and Vil, D and Shekher, M and Matero, A and Shah, R and Swaby, I and O'Shaughnessy, A and Rodriguez, M and Hoffmann, J and Till, S and Granat, S and Shohdy, N and Hasegawa, A and Hameed, A and Lodhi, M and Johnson, A and Chen, E and Marra, M and Martienssen, R and McCombie, WR},
  issn         = {0028-0836},
  journal      = {NATURE},
  keyword      = {PREDICTION,TELOMERE,FISSION YEAST,DNA-SEQUENCES,GENOMIC DNA,MODEL-PLANT,REGIONS,RFLP,RNA,RECOMBINATION},
  language     = {eng},
  number       = {6763},
  pages        = {769--777},
  title        = {Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana},
  url          = {http://dx.doi.org/10.1038/47134},
  volume       = {402},
  year         = {1999},
}

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