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Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis

(2013) REVISTA DE SAUDE PUBLICA. 47(4). p.813-816
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Abstract
OBJECTIVE: To assess the increased diagnostic yield for pulmonary tuberculosis using bronchial washing cultures compared with sputum cultures. METHODS: Study conducted with 61 adults in Lima, Peru, from January 2006 to December 2007. The yield of sputum cultures was compared with the yield of acid-fast bacilli smears and cultures of bronchial washing for diagnosing pulmonary tuberculosis in suspected cases of clinical tuberculosis with negative acid fast bacilli sputum smears. RESULTS: Twenty seven (95% CI 32; 58) of the cases were eventually diagnosed with smear-negative pulmonary tuberculosis. Bronchial washing samples detected 23 (95% CI 72; 99) of the smear-negative pulmonary tuberculosis cases compared with 15 (95% CI 37; 74) for sputum cultures (p = 0.02). The incremental diagnostic yield of acid fast bacilli smear and culture of bronchial washing specimens over sputum culture was 44% (95% CI 25; 65). CONCLUSIONS: In function of the epidemiological context and the resources available, bronchoscopy should be deployed as part of a comprehensive work up that optimizes smear-negative pulmonary tuberculosis diagnosis and minimizes risk and costs.
Keywords
Sensitivity and Specificity, diagnosis, Diagnostic Techniques and Procedures, Tuberculosis, Bronchoalveolar Lavage

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Please use this url to cite or link to this publication:

Chicago
Soto, Alonso, Vilma Acurio, Lely Solari, and Patrick Van Der Stuyft. 2013. “Incremental Yield of Bronchial Washing for Diagnosing Smear-negative Pulmonary Tuberculosis.” Revista De Saude Publica 47 (4): 813–816.
APA
Soto, A., Acurio, V., Solari, L., & Van Der Stuyft, P. (2013). Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis. REVISTA DE SAUDE PUBLICA, 47(4), 813–816.
Vancouver
1.
Soto A, Acurio V, Solari L, Van Der Stuyft P. Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis. REVISTA DE SAUDE PUBLICA. 2013;47(4):813–6.
MLA
Soto, Alonso et al. “Incremental Yield of Bronchial Washing for Diagnosing Smear-negative Pulmonary Tuberculosis.” REVISTA DE SAUDE PUBLICA 47.4 (2013): 813–816. Print.
@article{4306253,
  abstract     = {OBJECTIVE: To assess the increased diagnostic yield for pulmonary tuberculosis using bronchial washing cultures compared with sputum cultures.
METHODS: Study conducted with 61 adults in Lima, Peru, from January 2006 to December 2007. The yield of sputum cultures was compared with the yield of acid-fast bacilli smears and cultures of bronchial washing for diagnosing pulmonary tuberculosis in suspected cases of clinical tuberculosis with negative acid fast bacilli sputum smears.
RESULTS: Twenty seven (95% CI 32; 58) of the cases were eventually diagnosed with smear-negative pulmonary tuberculosis. Bronchial washing samples detected 23 (95% CI 72; 99) of the smear-negative pulmonary tuberculosis cases compared with 15 (95% CI 37; 74) for sputum cultures (p = 0.02). The incremental diagnostic yield of acid fast bacilli smear and culture of bronchial washing specimens over sputum culture was 44% (95% CI 25; 65).
CONCLUSIONS: In function of the epidemiological context and the resources available, bronchoscopy should be deployed as part of a comprehensive work up that optimizes smear-negative pulmonary tuberculosis diagnosis and minimizes risk and costs.},
  author       = {Soto, Alonso and Acurio, Vilma and Solari, Lely and Van Der Stuyft, Patrick},
  issn         = {0034-8910},
  journal      = {REVISTA DE SAUDE PUBLICA},
  keywords     = {Sensitivity and Specificity,diagnosis,Diagnostic Techniques and Procedures,Tuberculosis,Bronchoalveolar Lavage},
  language     = {eng},
  number       = {4},
  pages        = {813--816},
  title        = {Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis},
  url          = {http://dx.doi.org/10.1590/S0034-8910.2013047004548},
  volume       = {47},
  year         = {2013},
}

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