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Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography

Mike De Vrieze, Frederic Lynen UGent, Dieter Verzele, Roman Szucs UGent and Patrick Sandra UGent (2014) 13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of abstracts.
abstract
Several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier into the central nervous system. In this article, the performance of three stationary phases for immobilized artificial membrane (IAM) liquid chromatographic approaches were compared on a set of 49 compounds. IAM liquid chromatography measurements were performed with Dulbecco’s phosphate-buffered saline and methanol as organic modifier in the mobile phase. Transport across the blood-brain barrier (log BB) was predicted using computed descriptor data and the retention factor of all compounds. All data were correlated with experimental log BB values and the relative performance of the approaches was studied. The IAM.PC.DD2 column proved to be the best suited for prediction of log BB values, although all three columns performed very good.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
Blood-brain barrier, Immobilized Artificial Membranes
in
13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of abstracts
conference name
13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) ; 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3)
conference location
Brugge, Belgium
conference start
2014-01-28
conference end
2014-01-31
language
English
UGent publication?
yes
classification
C3
additional info
uploaded document is poster
copyright statement
I have retained and own the full copyright for this publication
id
4295548
handle
http://hdl.handle.net/1854/LU-4295548
date created
2014-02-19 08:30:46
date last changed
2016-12-19 15:36:32
@inproceedings{4295548,
  abstract     = {Several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier into the central nervous system. In this article, the performance of three stationary phases for immobilized artificial membrane (IAM) liquid chromatographic approaches were compared on a set of 49 compounds. IAM liquid chromatography measurements were performed with Dulbecco{\textquoteright}s phosphate-buffered saline and methanol as organic modifier in the mobile phase. Transport across the blood-brain barrier (log BB) was predicted using computed descriptor data and the retention factor of all compounds. All data were correlated with experimental log BB values and the relative performance of the approaches was studied. The IAM.PC.DD2 column proved to be the best suited for prediction of log BB values, although all three columns performed very good.},
  author       = {De Vrieze, Mike and Lynen, Frederic and Verzele, Dieter and Szucs, Roman and Sandra, Patrick},
  booktitle    = {13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of abstracts},
  keyword      = {Blood-brain barrier,Immobilized Artificial Membranes},
  language     = {eng},
  location     = {Brugge, Belgium},
  title        = {Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography},
  year         = {2014},
}

Chicago
De Vrieze, Mike, Frederic Lynen, Dieter Verzele, Roman Szucs, and Patrick Sandra. 2014. “Predicting Drug Penetration Across the Blood-brain Barrier: Comparison of Different Stationary Phases for Immobilized Artificial Membrane Liquid Chromatography.” In 13th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International Symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of Abstracts.
APA
De Vrieze, M., Lynen, F., Verzele, D., Szucs, R., & Sandra, P. (2014). Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography. 13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of abstracts. Presented at the 13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) ; 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3).
Vancouver
1.
De Vrieze M, Lynen F, Verzele D, Szucs R, Sandra P. Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography. 13th International symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of abstracts. 2014.
MLA
De Vrieze, Mike, Frederic Lynen, Dieter Verzele, et al. “Predicting Drug Penetration Across the Blood-brain Barrier: Comparison of Different Stationary Phases for Immobilized Artificial Membrane Liquid Chromatography.” 13th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology (HTC-13) and 3rd International Symposium on Hyphenated Techniques for Sample Preparation (HTSP-3), Book of Abstracts. 2014. Print.